Aging changes in the senses
https://doi.org/10.37586/2686-8636-1-2026-66-79
Abstract
BACKGROUND. The aging of the visual organ and other sensory systems is a key medical and social problem, as it leads to a decrease in quality of life, functional dependence and an increased burden of disease.
OBJECTIVE. Cataracts develop due to the accumulation of oxidative damage to the lens and disruptions in its biochemical composition. Age-related macular degeneration is associated with the accumulation of drusen, oxyinflammation, and immune mechanisms leading to pigment epithelial atrophy. Glaucomatous neurodegeneration is caused by optic nerve damage, excitotoxicity, mitochondrial dysfunction, and oxidative stress. Diabetic retinopathy is characterized by vascular and inflammatory changes, exacerbated by accelerated cellular aging. Dry eye syndrome is associated with dysfunction of the lacrimal and meibomian glands, as well as age-related decline in antioxidant defenses. The mechanisms of presbycusis and presbynasalis are also discussed.
CONCLUSION. Aging of sensory systems is a multifactorial process that forms a wide range of age-associated diseases. A comprehensive combination of clinical, molecular, and computational approaches opens new possibilities for personalized diagnostics, early detection, and the development of targeted anti-aging strategies aimed at preserving visual function and improving quality of life in the elderly population.
About the Author
A. D. Gotina
Geriatric Rehabilitation and Care Center for the Elderly «Senior Group Malakhovka»; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
References
1. Flaxman S. R., Bourne R. R. A., Resnikoff S., et al. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob Health. 2017 ; 5 (12) : e1221-e1234. DOI: 10.1016/S2214-109X(17)30393-5.
2. GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021 ; 9 (2) : e144-e160. DOI: 10.1016/S2214-109X(20)30489-7. Erratum in: Lancet Glob Health. 2021 ; 9 (4) : e 408.
3. Nita M., Grzybowski A. The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxid Med Cell Longev. 2016 ; 2016 : 3164734. DOI: 10.1155/2016/3164734.
4. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res. 2006 ; 25 (5) : 490–513. DOI: 10.1016/j.preteyeres.2006.07.003.
5. Ren J., Zhang S., Pan Y., et al. Diabetic retinopathy: Involved cells, biomarkers, and treatments. Front Pharmacol. 2022 ; 13 : 953691. DOI: 10.3389/fphar.2022.953691.
6. Horowitz A. The prevalence and consequences of vision impairment in later life. Topics in Geriatric Rehabilitation. 2004 ; 20 (3) : 185–195. DOI: 10.1097/00013614-200407000-00006.
7. Kempen G. I., Ballemans J., Ranchor A. V., et al. The impact of low vision on activities of daily living, symptoms of depression, feelings of anxiety and social support in community-living older adults seeking vision rehabilitation services. Qual Life Res. 2012 ; 21 (8) : 1405–1411. DOI: 10.1007/s11136-011-0061-y. Erratum in: Qual Life Res. 2012 ; 21 (8) : 1413.
8. Michael R., Bron A. J. The ageing lens and cataract: a model of normal and pathological ageing. Philos Trans R Soc Lond B Biol Sci. 2011 ; 366 (1568) : 1278–1292. DOI: 10.1098/rstb.2010.0300.
9. Crabb J. W., Miyagi M., Gu X., et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A. 2002 ; 99 (23) : 14682– 12687. DOI: 10.1073/pnas.222551899.
10. Cruz-Guilloty F., Saeed A. M., Duffort S., et al. T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS One. 2014 ; 9 (2) : e88201. DOI: 10.1371/journal.pone.0088201.
11. Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013 ; 309 (19) : 2005–2015. DOI: 10.1001/jama.2013.4997. Erratum in: JAMA. 2013 ; 310 (2) : 208.
12. Chakravarthy U., Harding S. P., Rogers C. A., et al. Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. Lancet. 2013 ; 382 (9900) : 1258–1267. DOI: 10.1016/S0140-6736(13)61501-9.
13. Yuki K., Ozawa Y., Yoshida T., et al. Retinal ganglion cell loss in superoxide dismutase 1 deficiency. Invest Ophthalmol Vis Sci. 2011 ; 52 (7) : 4143–4150. DOI: 10.1167/iovs.10-6294.
14. Osborne N. N. Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned. Acta Ophthalmol. 2009 ; 87 (4) : 450–454. DOI: 10.1111/j.1755-3768.2008.01459.x.
15. Vujosevic S., Aldington S. J., Silva P., et al. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol. 2020 ; 8 (4) : 337–347. DOI: 10.1016/S2213-8587(19)30411-5.
16. Jha A., Verma A., Alagorie A. R. Association of severity of diabetic retinopathy with corneal endothelial and thickness changes in patients with diabetes mellitus. Eye (Lond). 2022 ; 36 (6) : 1202–1208. DOI: 10.1038/s41433-021-01606-x.
17. Li Q., Wang M., Li X., Shao Y. Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes. Exp Gerontol. 2023 ; 175 : 112138. DOI: 10.1016/j.exger.2023.112138.
18. Nichols J. J. Citation analysis of the dry eye literature. Ocul Surf. 2013 ; 11 (1) : 35–46. DOI: 10.1016/j.jtos.2012.08.004.
19. Kawashima M., Tsubota K. Effect of calorie restriction on change in lacrimal gland with age. Cornea. 2011 ; 30 Suppl 1 : S29–S33. DOI: 10.1097/ICO.0b013e318228167f.
20. Ibrahim O. M., Dogru M., Matsumoto Y., et al. Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. PLoS One. 2014 ;9 (7) : e99328 . DOI: 10.1371/journal.pone.0099328.
21. Kojima T., Wakamatsu T. H., Dogru M., et al. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol. 2012 ; 180 (5) : 1879–1896. DOI: 10.1016/j.ajpath.2012.01.019.
22. Kawashima M., Uchino M., Yokoi N., et al. Decreased tear volume in patients with metabolic syndrome: the Osaka study. Br J Ophthalmol. 2014 ; 98 (3) : 418–420. DOI: 10.1136/bjophthalmol-2013-303953.
23. Osborne N. N., Núñez-Álvarez C., Del Olmo-Aguado S. The effect of visual blue light on mitochondrial function associated with retinal ganglions cells. Exp Eye Res. 2014 ; 128 : 8–14. DOI: 10.1016/j.exer.2014.08.012.
24. Orozco-Solis R., Sassone-Corsi P. Epigenetic control and the circadian clock: linking metabolism to neuronal responses. Neuroscience. 2014 ; 264 : 76-87. DOI: 10.1016/j.neuroscience.2014.01.043.
25. Yoshino J., Klein S. A novel link between circadian clocks and adipose tissue energy metabolism. Diabetes. 2013 ; 62 (7) : 2175–2177. DOI: 10.2337/db13-0457.
26. Narimatsu T., Negishi K., Miyake S., et al. Blue lightinduced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo. Exp Eye Res. 2015 ; 132 : 48–51. DOI: 10.1016/j.exer.2015.01.003.
27. Wolf J., Franco J. A., Yip R., et al. Liquid Biopsy Proteomics in Ophthalmology. J Proteome Res. 2024 ; 23 (2) : 511–522. DOI: 10.1021/acs.jproteome.3c00756.
28. Cao X., Sanchez J. C., Dinabandhu A., et al. Aqueous proteins help predict the response of patients with neovascular age-related macular degeneration to anti-VEGF therapy. J Clin Invest. 2022 ; 132 (2) : e144469. DOI: 10.1172/JCI144469.
29. Yang S., Zhao J., Sun X. Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review. Drug Des Devel Ther. 2016 ; 10 : 1857–1867. DOI: 10.2147/DDDT.S97653.
30. Velez G., Bassuk A. G., Colgan D., et al. Therapeutic drug repositioning using personalized proteomics of liquid biopsies. JCI Insight. 2017 ; 2 (24) : e97818. DOI: 10.1172/jci.insight.97818.
31. Midena E., Frizziero L., Midena G., Pilotto E. Intraocular fluid biomarkers (liquid biopsy) in human diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2021 ; 259 (12) : 3549–3560. DOI: 10.1007/s00417-021-05285-y.
32. Kersten E., Paun C. C., Schellevis R. L., et al. Systemic and ocular fluid compounds as potential biomarkers in agerelated macular degeneration. Surv Ophthalmol. 2018 ; 63 (1) : 9–39. DOI: 10.1016/j.survophthal.2017.05.003.
33. Mirzaei M., Gupta V. B., Chick J. M., et al. Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep. 2017 ; 7 (1) : 12685. DOI: 10.1038/s41598-017-12858-7.
34. Wattamwar K., Qian Z. J., Otter J., et al. Increases in the Rate of Age-Related Hearing Loss in the Older Old. JAMA Otolaryngol Head Neck Surg. 2017 ; 143 (1) : 41–45. DOI: 10.1001/jamaoto.2016.2661.
35. Pacher P., Beckman J. S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 ; 87 (1) : 315–424. DOI: 10.1152/physrev.00029.2006.
36. Lasisi A. O., Fehintola F. A. Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss. Acta Otolaryngol. 2011 ; 131 (11) : 1160–1164. DOI: 10.3109/00016489.2010.549840.
37. Menardo J., Tang Y., Ladrech S., et al. Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. Antioxid Redox Signal. 2012 ; 16 : 263–274. DOI: 10.1089/ars.2011.4037.
38. Mantha A. K., Sarkar B., Tell G. A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases. Mitochondrion. 2014 ; 16 : 38–49. DOI: 10.1016/j.mito.2013.10.007.
39. Howcroft T. K., Campisi J., Louis G. B., et al. The role of inflammation in age-related disease. Aging (Albany NY). 2013 ; 5 (1) : 84–93. DOI: 10.18632/aging.100531.
40. Uchida Y., Sugiura S., Sone M., et al. Progress and prospects in human genetic research into age-related hearing impairment. Biomed Res Int. 2014 ; 2014 : 390601. DOI: 10.1155/2014/390601.
41. Fujimoto C., Yamasoba T. Oxidative stresses and mitochondrial dysfunction in age-related hearing loss. Oxid Med Cell Longev. 2014 ; 2014 : 582849. DOI: 10.1155/2014/582849.
42. Zárate S., Stevnsner T., Gredilla R. Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair. Front Aging Neurosci. 2017 ; 9 : 430. DOI: 10.3389/fnagi.2017.00430.
43. Jönsson R., Rosenhall U., Gause-Nilsson I., Steen B. Auditory function in 70- and 75-year-olds of four age cohorts. A cross-sectional and time-lag study of presbyacusis. Scand Audiol. 1998 ; 27 (2) : 81–93. DOI: 10.1080/010503998420324.
44. Stenberg A. E., Nylén O., Windh M., Hultcrantz M. Otological problems in children with Turner's syndrome. Hear Res. 1998 ; 124 (1–2) : 85–90. DOI: 10.1016/s0378-5955(98)00113-0.
45. Hultcrantz M., Simonoska R., Stenberg A. E. Estrogen and hearing: a summary of recent investigations. Acta Otolaryngol. 2006 ; 126 (1) : 10–14. DOI: 10.1080/00016480510038617.
46. Viana L. M., O'Malley J. T., Burgess B. J., et al. Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue. Hear Res. 2015 ; 327 : 78– 88. DOI: 10.1016/j.heares.2015.04.014.
47. Chen H., Xing Y., Xia L., et al. AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy. Gene Ther. 2018 ; 25 (4) : 251–259. DOI: 10.1038/s41434-018-0012-0.
48. DelGaudio J. M., Panella N. J. Presbynasalis. Int Forum Allergy Rhinol. 2016 ;6 (10) : 1083–1087. DOI: 10.1002/alr.21787.
49. Valdés C. J., Tewfik M. A. Rhinosinusitis and Allergies in Elderly Patients. Clin Geriatr Med. 2018 ; 34 (2) : 217–231. DOI: 10.1016/j.cger.2018.01.009.
50. Loftus P. A., Wise S. K., Nieto D., et al. Intranasal volume increases with age: Computed tomography volumetric analysis in adults. Laryngoscope. 2016 ; 126 (10) : 2212–2215. DOI: 10.1002/lary.26064.
51. Doty R. L., Shaman P., Applebaum S. L., et al. Smell identification ability: changes with age. Science. 1984 ; 226 (4681) : 1441–1443. DOI: 10.1126/science.6505700.
52. Santos D. V., Reiter E. R., DiNardo L. J., Costanzo R. M. Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg. 2004 ; 130 (3) : 317–319. DOI: 10.1001/archotol.130.3.317.
53. Goncalves S., Goldstein B. J. Pathophysiology of Olfactory Disorders and Potential Treatment Strategies. Curr Otorhinolaryngol Rep. 2016 ; 4 (2) : 115–121. DOI: 10.1007/s40136-016-0113-5.
54. Liu G., Zong G., Doty R. L., Sun Q. Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study. BMJ Open. 2016 ; 6 (11) : e013246. DOI: 10.1136/bmjopen-2016-013246.
55. LaForce C., Journeay G. E., Miller S. D., et al. Ocular safety of fluticasone furoate nasal spray in patients with perennial allergic rhinitis: a 2-year study. Ann Allergy Asthma Immunol. 2013 ; 111 (1) : 45–50. DOI: 10.1016/j.anai.2013.04.013.
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For citations:
Gotina A.D. Aging changes in the senses. Russian Journal of Geriatric Medicine. 2026;(1):66-79. (In Russ.) https://doi.org/10.37586/2686-8636-1-2026-66-79
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