Subjective Cognitive Decline in Clinical Practice
https://doi.org/10.37586/2686-8636-4-2025-571-579
Abstract
Individuals with subjective cognitive decline (SCD) who experience cognitive complaints are considered to have cognitive abilities within the age-appropriate range based on cognitive tests and to have no significant mental, neurological, or somatic disorders affecting cognitive function. SCD in older adults is considered an early marker of severe cognitive impairment in neurodegenerative diseases such as Alzheimer's disease. This review discusses the sociodemographic characteristics of SCD and examines the relationship between subjective assessment and objective measures of cognitive function. Although individuals with SCD may not exhibit clinically significant cognitive deficits, increasing evidence suggests subtle cognitive and neurobiological differences compared to healthy older adults of the same age. The relationship of SCD to the concept of cognitive fragility is discussed: reversible cognitive fragility is essentially SCD and is considered important for intervention and the potential prevention or delay of dementia. In the elderly, SCD is associated with impairments in their daily lives, problems, and difficulties with social participation. Currently, increasing attention is being paid to the treatment of patients with SCD, but pharmacological treatments are not the treatment of choice. The association of asthenic symptoms and cognitive impairments warrants the prescription of medications that provide a comprehensive psychostimulant and nootropic effect. In this context, having Prospekta in a physician's repertoire may be useful for the treatment of cognitive impairment and asthenia.
Keywords
pre-dementia cognitive impairment,
subjective cognitive decline,
cognitive fragility,
cognitive asthenia,
Prospekta
Supporting agencies: The work was carried out with the support of RPC MATERIA MEDICA HOLDING LLC.
About the Author
N. N. Koberskaya
Faculty of General Medicine, Sechenov First Moscow State Medical University of the Ministry of Heath of the Russian Federation (Sechenov University); Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation (Pirogov University), Russian Gerontological Research and Clinical Center
Russian Federation
Russian Federation
Koberskaya Nadezhda Nikolaevna
Moscow
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For citations:
Koberskaya N.N. Subjective Cognitive Decline in Clinical Practice. Russian Journal of Geriatric Medicine. 2025;(4):571-579. (In Russ.) https://doi.org/10.37586/2686-8636-4-2025-571-579
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