Postcovid syndrome: illusion or reality?
https://doi.org/10.37586/2686-8636-1-2022-43-47
Abstract
A novel coronavirus infection was described in 2019 in Wuhan, China. From the first months of the spread of the infection around the world, evidence began to appear that patients after recovery had various symptoms. Duration, intensity, and variability of symptoms varies among patients and are often not associated with the severity of the most acute illness. Recently the concept of post-COVID syndrome (post-COVID or long-COVID in the English-language literature) has acquired increasingly clear diagnostic criteria. Persistent symptoms and / or the appearance of delayed complications after 4 weeks or more from the onset of symptoms of an acute illness are commonly called post-COVID syndrome. This review provides information on post-COVID syndrome, its pathophysiology and specific organ lesions. Relevant data on the interdisciplinary management of patients who have undergone a new coronavirus infection will be considered and an algorithm for identifying the diagnosis will be proposed.
About the Authors
K. A. Eruslanova
Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
junior research fellow, Laboratory of Vascular Ageing
+7(499)187-78-09
Moscow
A. V. Rozanov
Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Assistant Director for Regional Development and Federal Projects
+7(985)991-75-47
Moscow
Yu. V. Kotovskaya
Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, professor, Deputy Director
+7(499)187-78-09
Moscow
O. N. Tkacheva
Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, professor, Director
+7(499)187-64-67
Moscow
References
1. World Health Organization. Weekly epidemiological update on COVID-19. https://www.who.int/publications/m/item/weekly-epidemiological-update-oncovid-19—28-december-2021
2. Tolksdorf K., Buda S., Schuler E., Wieler L.H., Haas W. Eine höhere Letalität und lange Beatmungsdauer unterscheiden COVID-19 von schwer verlaufenden Atemwegsinfektionen in Grippewellen. Epidemiol Bull 2020; 41: 3–10.
3. Ellul M.A., Benjamin L., Singh B., Lant S., Michael B.D., Easton A., et al. Neurological associations of COVID-19. Lancet Neurol 2020; 19: 767–783.
4. Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397: 220–232.
5. Chopra V., Flanders S.A. & O’Malley M. Sixty-day outcomes among patients hospitalized with COVID-19. Ann. Intern. Med. https://doi.org/10.7326/M20–5661 (2020)
6. Carvalho-Schneider C. et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin. Microbiol. Infect. 27; 258–263 (2021).
7. Arnold D.T. et al. Patient outcomes after hospitalization with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax https://doi.org/10.1136/thoraxjnl-2020–216086 (2020)
8. Moreno-Pérez O. et al. Post-acute COVID-19 syndrome. Incidence and risk factors: a Mediterranean cohort study. J. Infect. https://doi.org/10.1016/j.jinf.2021.01.004 (2021)
9. Halpin S.J. et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. J. Med. Virol. 93; 1013–1022 (2021). 10. Jacobs L.G. et al. Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS ONE 15, e0243882 (2020).
10. Petersen E.L., Goßling A., Adam G., et al. Multi-organ assessment in mainly non-hospitalized individuals after SARSCoV-2 infection: The Hamburg City Health Study COVID programme [published online ahead of print, 2022 Jan 6]. Eur Heart J. 2022;ehab914. DOI: 10.1093/eurheartj/ehab914
11. Nalbandian A., Sehgal K., Gupta A., et al. Post-acute COVID-19 syndrome. Nat Med. 2021; 27(4): 601–615. DOI: 10.1038/s41591–021–01283-z
12. Inoue S. et al. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med. Surg. 6; 233–246 (2019).
13. SYNTHESIS. LONG COVID: PATHOPHYSIOLOGY — EPIDEMIOLOGY AND PATIENT NEEDS. Belgian Health Care Knoweldge Center. 2021.
14. George P.M., Wells A.U., Jenkins R.G. Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy. Lancet Respir Med. 2020; 8(8): 807–815. DOI: 10.1016/S2213–2600(20)30225–3.
15. Acat M., Yildiz Gulhan P., Oner S., Turan M.K. Comparison of pirfenidone and corticosteroid treatments at the COVID-19 pneumonia with the guide of artificial intelligence supported thoracic computed tomography. Int J Clin Pract. 2021; 75(12): e14961. DOI: 10.1111/ijcp.14961.
16. Puntmann V.O. et al. Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19). JAMA Cardiol. 5, 1265–1273 (2020).
17. Rajpal S. et al. Cardiovascular magnetic resonance findings in competitive athletes recovering from COVID-19 infection. JAMA Cardiol. 6; 116–118 (2021).
18. Ramacciotti E., Barile Agati L., Calderaro D., et al. Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised, controlled trial. Lancet. 2022; 399(10319): 50–59. DOI: 10.1016/S0140–6736(21)02392–8.
19. Berger J.S., Kornblith L.Z., Gong M.N., et al. Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022; 327(3): 227–236. DOI: 10.1001/jama.2021.23605.
20. Cummings M.J. et al. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet 395; 1763–1770 (2020).
21. Stevens J.S. et al. High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. PLoS ONE 15, e0244131 (2020).
Review
For citations:
Eruslanova K.A., Rozanov A.V., Kotovskaya Yu.V., Tkacheva O.N. Postcovid syndrome: illusion or reality? Russian Journal of Geriatric Medicine. 2022;(1):43-47. (In Russ.) https://doi.org/10.37586/2686-8636-1-2022-43-47
Views:
3609
Email this article 