Lipid and glucose metabolism in centenarians: risk factors of cardiovascular diseases and frailty

Aim: to assess the most important metabolic factors in centenarians and their impact on prognosis
Materials and methods. It was a longitudinal study, including 64 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment (FRAIL, IADL-C, MNA, GDS-15 and МOCA scores) and blood tests (HbA1c, cholesterol, LDL, HDL and TG) were performed. In 3 years we contacted patients’ relatives or social workers to find out about patients’ status.
Results. Mean age of the patients was 98,3±1,9 years. We found out that 34,4% of the patients were frail. Cognitive impairments of different severity were presented in 84,4% of the patients. The median lipids values were as follows: cholesterol — 4,8 [4,2 ;5,8], TG — 0.97 [0,8; 1.2], HDL — 1.3 [4.2; 5,8), LDL — 3,1 [2,6; 3,7], HbA1c — 5,8 [5,6; 6,1]. In 59% of the patients HbA1c was below 6%; 33% had concentrations between 6% and 6,4%, and only in 8% we found HbA1c higher than 6,5%. No correlation was also found between HbA1c values and lipids profile. Comparing survivors and non-survivors groups we did not find any significant differences in total cholesterol, LDL, HDL and HbA1c (p<0,005). While comparing functional status with metabolic profile we discovered positive correlation (r= 0.834) between total cholesterol and index of instrumental activity, and between LDL and IADL as well as MNA score (r=0.732 and 0.634 respectively).
Conclusions. In centenarians usual prognostic factors such as HbA1c and lipids do not have any impact on prognosis but they influence functional status and QoL. Further investigations of metabolic status in super old persons are needed to personalize their lifestyle and treatment goals.

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