Modern aspects of diagnosis and treatment of mild cognitive impairment
https://doi.org/10.37586/2686-8636-3-2020-199-204
Abstract
The study of cognitive impairments (CI) began with a more severe form- dementia, which is usually the result of a long-running pathological process. It is preceded by non-demented cognitive disorders (including mild cognitive impairment syndrome — MCI), whose early detection increases the potential for therapeutic effects and even prevention of disadaptation as a result of dementia. The article reviews current publications on the problem of MCI. Special attention is paid to the diagnosis and treatment of this clinically heterogeneous syndrome. Historical issues of MCI studying are considered, modern principles of its classification and diagnostic criteria are given, and the main aspects of patient management are described. The results of a number of russian and international studies of MCI syndrome are described, including a comparison of these data among themselves.
About the Author
A. B. Lokshina
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University); Pirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Assistant to the Department of Nervous Diseases and Neurosurgery, Institute of Clinical Medicine named after N.V. Sklifosovsky Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University); Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.
Moscow.
+7(916) 243-00-28
References
1. Yakhno N.N. Cognitive Disorders in a Neurological Clinic. Nevrologicheskiy Zhurnal. 2006; 11(S. 1): 4—12. (in Russ.).
2. Yakhno N.N., Zakharov V.V., Lokshina A.B., Koberskaya N.N., Mkhitaryan E.A. Dementia. Guidance for doctors. M.: MEDpress-inform; 2011: 17-28. Accessed May 30, 2020 (in Russ.) https://www.03book.ru/upload/iblock/987/415_Demencija_Jahno.pdf
3. Yakhno N.N., Zakharov V.V., Lokshina A.B. Moderate cognitive impairment syndrome in cerebral vascular insufficiency. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2005; 105(2): 13-17. Accessed May 30, 2020 (in Russ.) http://www.scopus.com/inward/record.url?eid=2-s2.0-17144396683&partnerID=MN8TOARS
4. Yakhno N.N., Zakharov V.V., Koberskaya N.N., Mhitaryan E.A., Grishina D.A., Lokshina A.B., Savushkina I.Y., Posohov S.I. Premild (subjective and subtle) cognitive disorders. Nevrologicheskiy Zhurnal. 2017; 22(4): 198-204. (in Russ.) DOI: 10.18821/1560-9545-2017-22-4-198-204.
5. Zakharov V.V., Savushkina I.Y., Mkhitaryan E.A., Koberskaya N.N., Lokshina A.B., Grishina D.A., Posokhov C.I., Tarapovskaya A.V., Yakhno N.N. Age-Related Dynamics of Cognitive Functions in Persons Aged 50-85 Years. Advances in Gerontology. 2018; 8(1): 41-46. DOI: 10.1134/S2079057018010137.
6. Yakhno N.N., Zakharov V.V., Lokshina A.B. Impairment of memory and attention in the elderly. Neuroscience and Behavioral Physiology. 2007; 37(3): 203-208. DOI: 10.1007/s11055-007-0002-y.
7. Petersen R.C., Lopez O., Armstrong M.J., et al. Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018; 90(3): 126-135. DOI: 10.1212/WNL.0000000000004826.
8. Roberts R.O., Geda Y.E., Knopman D.S., et al. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology. 2008; 30(1): 58-69. DOI: 10.1159/000115751.
9. Plassman B.L., Langa K.M., Fisher G.G., et al. Prevalence of cognitive impairment without dementia in the United States [published correction appears in Ann Intern Med. 2009 Aug 18; 151(4): 291-2]. Ann Intern Med. 2008; 148(6): 427-434. DOI: 10.7326/0003-4819-148-6-200803180-00005.
10. Farias S.T., Mungas D., Reed B.R., Harvey D., DeCarli C. Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts. Arch Neurol. 2009; 66(9): 1151-1157. DOI: 10.1001/archneurol.2009.106.
11. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Kokmen E., Tangelos E.G. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997; 9 Suppl 1: 65-69. DOI: 10.1017/s1041610297004717.
12. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56(3): 303-308. DOI: 10.1001/archneur.56.3.303.
13. Petersen R.C., Stevens J.C., Ganguli M., Tangalos E.G., Cummings J.L., DeKosky S.T. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001; 56(9): 1133-1142. DOI: 10.1212/wnl.56.9.1133.
14. Petersen RC. Mild cognitive impairment: where are we? Alzheimer Dis Assoc Disord. 2005; 19(3): 166-169. DOI: 10.1097/01.wad.0000179417.95584.90.
15. Touchon J. Recent consensus efforts in the diagnosis of mild cognitive impairment. Psychogeriatrics [Internet]. Wiley; 2006; 6(s1): S23-S25. DOI: 10.1111/j.1479-8301.2006.00130.x.
16. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Diseases. Fifth Edition. (DSM-V). London; 2013. https://www.psychiatry.org/psychiatrists/practice/dsm
17. Dementia. Comprehensive Principles and Practice. Oxford University Press; 2014: 377-383, 432448. DOI: 10.1093/med/9780199928453.001.0001.
18. Zakharov V.V. Dopaminergic and noradrenergic therapy of cognitive impairment. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2006; 106 (9): 43-47. Accessed May 30, 2020 (in Russ.) http://www.scopus.com/inward/record.url?eid=2-s2.0-69149086646&partnerID=MN8TOARS
19. Yakhno N.N., Lokshina A.B., Zakharov V.V., Grishina D.A., Koberskaya N.N., Mkhitaryan E.A., Mild cognitive impairment in Russian population. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2019; 119(5): 179-180. (in Russ.) DOI: 10.17116/jnevro201911905S.
20. Richard E., Schmand B.A., Eikelenboom P., Van Gool W.A. Alzheimer's Disease Neuroimaging Initiative. MRI and cerebrospinal fluid biomarkers for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: a diagnostic accuracy study. BMJ Open. 2013; 3(6): e002541. DOI: 10.1136/bmjopen-2012-002541.
21. Yahno N.N., Preobrazhenskaya I.S., Zakharov V.V., Mkhitaryan E.A. The effectiveness of memantine administtasion in patients with non-dementia cognitive impairment. The results of a multicenter clinical follow-up study. Rossiiskii Nevrologicheskiy Zhurnal. 2019; (3): 37-44. (in Russ.) DOI: 10.30629/2658-7947-2019-24-3-37-44.
22. Yan S., Fu W., Wang C., et al. Association between sedentary behavior and the risk of dementia: a systematic review and meta-analysis. Transl Psychiatry. 2020; 10(1): 112. DOI: 10.1038/s41398-020-0799-5.
23. Zhu Y., Zhong Q., Ji J., et al. Effects of Aerobic Dance on Cognition in Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020; 74(2): 679690. DOI: 10.3233/JAD-190681.
24. Bauer C.E., Brown C.A., Gold B.T. Alzheimer's Disease Neuroimaging Initiative. Education does not protect cognitive function from brain pathology in the ADNI 2 cohort. Neurobiol Aging. 2020; 90: 147-149. DOI: 10.1016/j.neurobiolaging.2019.11.017.
Review
For citations:
Lokshina A.B. Modern aspects of diagnosis and treatment of mild cognitive impairment. Russian Journal of Geriatric Medicine. 2020;(3):199-204. (In Russ.) https://doi.org/10.37586/2686-8636-3-2020-199-204
Views:
1187
Email this article 