The influence of extragenital diseases on the development of pelvic organ prolapse in women

Abstract

BACKGROUND. Pelvic organ prolapse (POP) remains a pressing medical issue that significantly affects women's quality of life. Although the role of obstetric and gynecological factors, such as multiple childbirths and age-related changes, has been established, the contribution of extragenital pathologies to the pathogenesis of POP remains insufficiently studied. Of particular importance is the increasing prevalence of comorbid conditions, including hypertension (HTN), diabetes mellitus (DM), and hypothyroidism, which may influence the development of structural disorders in connective tissue and pelvic floor muscles. A comprehensive analysis of the relationship between these diseases and POP is necessary to develop preventive measures and optimize treatment strategies.