Aging bone
https://doi.org/10.37586/2686-8636-2-2020-147-153
Abstract
This review article deals with the topic of changes in bone tissue in the process of aging of the body. Adipogenesis and osteogenesis are affected at the molecular level, proteins and genes are described, in which somatic mutation can occur during the aging process, resulting in both minor changes and an active loss of bone mineral density. The factors that affect the change in bone mineral density mainly in the elderly, and existing drugs that can slow down osteoporosis are listed. Knowledge of the cellular and molecular mechanisms underlying the aging of bone tissue will contribute to the creation of targeted therapy for osteoporosis, which slows down bone aging and prevents falls and fractures in the elderly people.
About the Authors
N. V. Brailova
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Clinical and Research Center of Gerontology
Russian Federation
Russian Federation
MD, PhD, junior research fellow, laboratory of age-related endocrine and metabolic disorders
eLibrary SPIN: 2900-8384
Moscow
V. A. Kuznetsova
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Student
eLibrary SPIN: 8617-4030
Moscow
E. N. Dudinskaya
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Clinical and Research Center of Gerontology
Russian Federation
Russian Federation
MD, PhD, Head of age-related endocrine and metabolic disorders laboratory
+7(903) 191-46-90
Moscow
O. N. Tkacheva
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Clinical and Research Center of Gerontology
Russian Federation
Russian Federation
MD, PhD, professor, Director
+7(499) 187-64-67
Moscow
References
1. J.M. Gimble, Z. Floyd E., M. Kassem, M.E. Nuttall. Aging and Bone. In: Duque, Gustavo, Kiel, Douglas P, eds. Osteoporosis in Older Persons. Springer International Publishing. 2016: 23–42. DOI: 10.1007/978-3-319-25976-5.
2. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Experimental Cell Research. 1961; 25: 585–621. DOI: 10.1016/0014-4827(61)90192-6.
3. Olsen B.R. Bone embryology, 6th edition. Washington: American Society for Bone and Mineral Research. 2006.
4. Muruganandan S., Roman A.A., Sinal C.J. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program. Cellular and Molecular Life Sciences. 2008; 6(2): 236–253. DOI: 10.1007/s00018-008-8429-z.
5. Rosen E.D., Walkey C.J., Puigserver P., Spiegelman B.M. Transcriptional regulation of adipogenesis. Genes Dev. 2000; 14: 1293–1307.
6. Stachecka J., Nowacka-Woszuk J., Kolodziejski P.A., Szczerbal I. The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis. Chromosome Research. 2019 (Epub ahead of print). DOI:10.1007/s10577-019-09604-2
7. Lee J.E., Ge K. Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis. Cell Biosci. 2014; 4: 29. DOI: 10.1186/2045-3701-4-29.
8. Li X., Shi S., Chen J., Zhong G., Li X., Liu Z. Leptin differentially regulates endochondral ossification in tibial and vertebral epiphyseal plates. Cell Biology International. 2017; 42(2): 169–179. DOI: 10.1002/cbin.10882.
9. Nirmala F.S., Lee H., Kim J., Jung C.H., Ha T., Jang Y.J., Ahn J. Fermentation Improves the Preventive Effect of Soybean Against Bone Loss in Senescence Accelerated Mouse Prone 6. Journal of Food Science. 2019; 84(2): 349–357. DOI: 10.1111/1750-3841.14433.
10. Reid I.R. Relationships between fat and bone. Osteoporosis International. 2007; 19(5): 595–606. DOI: 10.1007/s00198-007-0492-z.
11. De Laet C., Kanis J.A., Oden A., Johanson H., Johnell O., Delmas P., Eisman J.A., et al. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int. 2005; 16(11): 1330–8. DOI: 10.1007/s00198-005-1863-y.
12. Ahmed L.A., Schirmer H., Berntsen G.K., Fonnebo V., Joakimsen RM. Features of the metabolic syndrome and the risk of non-vertebral fractures: The Tromso study. Osteoporos Int. 2009; 20(5): 839. DOI: https://doi.org/10.1007/s00198-005-0003-z.
13. Lau A.N., Adachi J.D. Bone Aging. In: Nakasato Y, Yung R, eds. Geriatric Rheumatology. New York: Springer. 2011: 11–16. DOI: 10.1007/978-1-4419-5792-4_2.
14. Reid I.R., Miller P.D., Brown J.P., et al. Effects of denosumab on bone histomorphometry: The FREEDOM and STAND studies. J Bone Miner Res. 2010; 25(10): 2256–2265. DOI: 10.1002/jbmr.149.
15. Anagnostis P., Gkekas N.K., Potoupnis M., Kenanidis E., Tsiridis E., Goulis D.G. New therapeutic targets for osteoporosis. Maturitas. 2019; 120: 1–6. DOI: 10.1016/j.maturitas.2018.11.010.
Review
For citations:
Brailova N.V., Kuznetsova V.A., Dudinskaya E.N., Tkacheva O.N. Aging bone. Russian Journal of Geriatric Medicine. 2020;(2):147-153. (In Russ.) https://doi.org/10.37586/2686-8636-2-2020-147-153
Views:
1651
Email this article 