Clinical guidelines frailty. Part 2
O. N. Tkacheva,
Yu. V. Kotovskaya,
N. K. Runikhina,
E. V. Frolova,
A. V. Naumov,
N. M. Vorobyeva,
V. S. Ostapenko,
E. A. Mkhitaryan,
N. V. Sharashkina,
E. A. Tyukhmenev,
A. P. Pereverzev,
E. N. Dudinskaya https://doi.org/10.37586/2686-8636-2-2020-115-130
Abstract
The paper represents clinical guidelines on frailty, developed by Russian Association of gerontologists and geriatricians. The guidelines are dedicated to geriatricians, internal medicine specialists, general practitioners, family doctors and other specialists, dealing with adult patients. This publication includes treatment options for patients with frailty.
About the Authors
O. N. Tkacheva
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, professor, Director
+7(499) 187-64-67
Moscow
Yu. V. Kotovskaya
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, professor, Deputy Director
+7(499) 187-78-09
Moscow
N. K. Runikhina
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Deputy Director
+7(499) 187-78-09
Moscow
E. V. Frolova
The North-Western State medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, PhD, Department of Family Medicine
+7 (812) 598-52-22
St-Petersburg
A. V. Naumov
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, professor of Agerelated diseases Departament, Head of Laboratory of musculoskeletal diseases
+7(926) 890-40-20
MoscowN. M. Vorobyeva
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Head of Laboratory of Cardiovascular Aging
+7(915) 192-22-78
Moscow
V. S. Ostapenko
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Head of geriatrics department
+7(916) 244-59-24
Moscow
E. A. Mkhitaryan
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD of the Department of Aging Diseases
+7(916) 653-36-78
Moscow
N. V. Sharashkina
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, head of Geriatricas and neurogeriatrics laboratory
+7(903) 244-27-50
Moscow
E. A. Tyukhmenev
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, head of outpatient department, senior research fellow, laboratory of the cardiovascular aging
eLibrary SPIN: 7746-8110
Researcher ID Web of Science: S-1048-2016
Moscow
A. P. Pereverzev
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Researcher of the Geriatrics Laboratory
+7(916) 538-87-81
Moscow
E. N. Dudinskaya
Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
MD, PhD, Head of age-related endocrine and metabolic disorders laboratory
+7(903) 191-46-90
MoscowReferences
1. Fried L.P. Frailty in older adults: evidence for a phenotype. J. Gerontol. Med. Sci. 2001; 56 (3): 146–156.
2. Mitnitski A.B., Mogilner A.J., Rockwood K. Accumulation of deficits as a proxy measure of aging. Scientific World J. 2001; 1: 323–336.
3. Vermeiren S. et al. Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. J Am Med Dir Assoc. 2016; 17(12): 1163.e1–1163.e17.
4. Weiss O.C. Frailty and Chronic Diseases in Older Adults. Clin. Geriatr. Med. 2011; 27: 39–52.
5. Clegg A. et al. Frailty in elderly people. The Lancet. 2013, Mar; 381(9868): 752–62.
6. Collard R.M. Prevalence of frailty in community dwelling older persons: a systematic review. J. Am. Geriatr. Soc. 2012; 60(8): 1487–1492.
7. Kojima G. Prevalence of frailty in nursing homes: A systematic review and metaanalysis. J. Am. Med. Dir. Assoc. 2015; 16: 940–945.
8. Gurina N.A., Frolova E.V., Degryse J.M. A roadmap of aging in Russia: the prevalence of frailty in community-dwelling older adults in the St. Petersburg district–the «Crystal» study. J. Amer. Geriatr. Soc. 2011; 59 (6): 980–988.
9. Остапенко В.С. Распространенность и структура гериатрических синдромов у пациентов амбулаторно-поликлинических учреждений г. Москвы: авторефер. дис. канд. мед.наук / В.С. Остапенко. М., 2017. 157 с.
10. Ткачева О.Н., Рунихина Н.К., Остапенко В.С., Шарашкина Н.В., Мхитарян Э.А., Онучина Ю.С., Лысенков С.Н. Валидация опросника для скрининга синдрома старческой астении в амбулаторной практике. Успехи геронтологии. 2017; 30; 2: 236–242.
11. Gutiérrez-Valencia M. The relationship between frailty and polypharmacy in older people: A systematic review. Br J ClinPharmacol. 2018. DOI: 10.1111/bcp.13590.
12. Buta B.J. Frailty assessment instruments: systematic characterization of the uses and contexts of highly – cited instruments. Ageing Res. Rev. 2016; 26: 53–61.
13. Morley J.E., Arai H., Cao L., Dong B., Merchant R.A., Vellas B., Visvanathan R., Woo J. Integrated Care: Enhancing the Role of the Primary Health Care Professional in Preventing Functional Decline: A Systematic Review. J Am Med Dir Assoc. 2017; 18(6): 489–494.
14. Reflection paper on physical frailty: instruments for baseline characterisation of older populations in clinical trials. https://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2018/02/WC500244285.pdf
15. Syddall H. et al. Is grip Strength a useful single marker of frailty? Age and Ageing. 2003; 32; 6: 650–656.
16. Borson S., Scanlan J., Brush M., Vitaliano P., Dokmak A. The Mini-Cog: a cognitive «vital signs» measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry. 2000; 15: 1021–1027.
17. Borson S., Scanlan J.M., Chen P., Ganguli M. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003; 51: 1451–1454.
18. Tsoi K.K., Chan J.Y., Hirai H.W., Wong S.Y., Kwok T.C. Cognitive tests to detect dementia: a systematic review and meta-analysis. JAMA Intern Med. 2015; 175: 1450–1458.
19. Бойцов С.А., Драпкина О.М., Калинина А.М., Ипатов П.В., Вергазова Э.К., Гамбарян М.Г., Еганян Р.А., Карамнова Н.С., Горный Б.Э., Егоров В.А., Соловьева С.Б., Старинский В.В., Бунова А.С., Ткачева О.Н., Рунихина Н.К., Котовская Ю.В., Мхитарян Э.А. «Организация проведения диспансеризации определенных групп взрослого населения». Методические рекомендации по практической реализации приказа Минздрава России от 26 октября 2017 г. № 869н «Об утверждении порядка проведения диспансеризации определенных групп взрослого населения». М., 2017. 162 с. Утверждены главным специалистом по профилактической медицине Минздрава России 27 декабря 2017 г. Интернет ресурсы: http://www.gnicpm.ru; http://ropniz.ru
20. Ramani L., Furmedge D.S., Reddy S.P. Comprehensive geriatric assessment. Br J Hosp Med Lond Engl 2005. 2014 Aug; 75 Suppl 8: 122–125.
21. British Geriatrics Society. Fit for Frailty Consensus best practice guidance for the care of older people living with frailty in community and outpatient settings [Internet]. 2014 Jun. Available from: http://www.bgs.org.uk/campaigns/fff/fff_full.pdf
22. Полипрагмазия в клинической практике: проблема и решения / под общей редакцией Д.А. Сычева, СПб.: ЦОП «Профессия», 2016. 224 с.
23. Naples J.G., Handler S.M., Maher R.L. et. al. Geriatric Pharmacotherapy and Polypharmacy. In: Fillit H.M., Rockwood K., Young J.B. Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 8th ed. Elsevier 2017; 849–854.
24. Kanis J.A., McCloskey E.V., Johansson H., Odén A., Borgström F., Strom O Development and use of FRAX® in osteoporosis. Osteoporosis International. 2010; 21 Suppl 2: 407–13.
25. Dent E., Visvanathan R., Piantadosi C., Chapman I. Use of the Mini Nutritional Assessment to detect frailty in hospitalised older people.J Nutr Health Aging. 2012; 16(9): 764–7
26. Guigoz Y., Vellas B., Garry P.J. Mini Nutritional Assessment: a practical assessment tool for grading the nutritional state of elderly patients. Facts Res. Gerontol. 1994; 2: 15–59.
27. Inzitari M. Gait speed predicts decline in attention and psychomotor speed in older adults: the health aging and body composition study. Neuroepidemiology. 2007; 29(3–4): 156–162.
28. Montero-Odasso M. Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. J. Gerontol. A Biol. Sci. Med. Sci. 2005; 60(10): 1304–1309.
29. Shinkai S. Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing. 2000; 29(5): 441–446.
30. Studenski S. Gait speed and survival in older adults. J.A.M.A. 2011; 305(1): 50–58.
31. Mahoney F., Barthel D. Functional evaluation: the Barthel Index. Md. State Med. J. 1965; 14: 61–65
32. Lawton M.P. and Brody E.M. «Assessment of older people: Self-maintaining and instrumental activities of daily living». Gerontologist. 1969; 9: 179–186.
33. Bohannon R.W. Reference values for the Timed Up and Go Test: A Descriptive Meta-Analysis. Journal of Geriatric Physical Therapy. 2006; 29(2): 64–8.
34. Morse J. M., Morse R., & Tylko S. Development of a scale to identify the fall-prone patient. Canadian Journal on Aging. 1989; 8: 366–377.
35. Shumway-Cook A., Brauer S., Woollacott M. Predicting the probability for falls in community-dwelling older adults using the timed up & go test. Phys Ther. 2000; 80: 896–903.
36. Kristensen M.T., Foss N.B., Kehlet H. Timed «Up and Go» Test as a predictor of falls within 6 months after hip fracture surgery. Phys Ther. 2007; 87(1): 24–30.
37. Eagle J., Salamara S., Whitman D., Evans L.A., Ho E., & Olde J.Comparison of three instruments in predicting accidental falls in selected inpatients in a general teaching hospital. Journal of Gerontological Nursing. 1999; 25(7): 40–45.
38. Folstein M.F., Folstein S.E., McHugh P.R. «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975; 12: 189–198.
39. Huntzinger J.A. Clock drawing in the screening assessment of cognitive impairment in an ambulatory care setting: a preliminary report. Gen. Hosp. Psychiatry. 1992; 14(2): 142–144
40. Nasreddine Z.S. Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. 2005; 53: 695–699.
41. Dubois B., Slachevsky A., Litvan I., Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology. 2000 Dec 12; 55(11): 1621–6.
42. Bingham K.S., Kumar S., Dawson D.R., Mulsant B.H., Flint A.J. A Systematic Review of the Measurement of Function in Late-Life Depression. Am J Geriatr Psychiatry. 2018; 26(1): 54–72. DOI: 10.1016/j.jagp.2017.08.011.
43. Sivertsen H., Bjørkløf G. H., Engedal K., Selbæk G., Helvik A. S. Depression and Quality of Life in Older Persons: A Review. Dement Geriatr Cogn Disord. 2015; 40 (5–6): 311–39.
44. Meeks T.W., Vahia I.V., Lavretsky H., Kulkarni G., Jeste D. A tune in «a minor» can «b major»: a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults. Research Report. J. Affect. Disord. 2011; 129: 126–142.
45. Katon W.J., Lin E., Russo J., Unutzer J. Increased medical costs of a population based sample of depressed elderly patients. Arch. Gen. Psychiatry. 2003; 60: 897–903.
46. Sheikh J.I., Yesavage J.A. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontologist. 1986; 56: 165–173.
47. Н.В. Погосова, Т.В. Довженко, А.Г. Бабин, А.А. Курсаков, В.А. Выгодин. Русскоязычная версия опросников PHQ-2 и 9: чувствительность и специфичность при выявлении депрессии у пациентов общемедицинской амбулаторной практики. Кардиоваскулярная терапия и профилактика. 2014, 13, 3
48. Alexopoulos G.A., Abrams R.C., Young R.C. & Shamoian C.A.: Cornell scale for depression in dementia. Biol Psych, 1988, 23: 271–284.
49. Ткачева О.Н. и соавт. Методические рекомендации по предупреждению жестокого обращения с пожилыми людьми в учреждениях здравоохранения. Методические указания. М.: Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, 2017. 25 с.
50. http://rgnkc.ru/images/pdf_documets/Zhestokoe_obrashenie_preduprezhdenie.pdf
51. Макушкин Е.В., Полищук Ю.И., Рунихина Н.К., Панченко Е.А. Выявление и профилактика жестокого обращения с пожилыми и престарелыми людьми в учреждениях здравоохранения и социальной защиты. Помощь жертвам жестокого обращения: Методические рекомендации. М.: ФГБУ «НМИЦ ПН им. В.П. Сербского» Минздрава России. 2017. 23 с.
52. Stevens P.E., Levin A.; Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members Ann Intern Med. 2013 Jun 4; 158(11): 825–30.
53. Röhrig G. Anemia in the frail, elderly patient. ClinInterv Aging. 2016; 11: 319–26.
54. Beghe C., Wilson A., Ershler W.B. Prevalence and Outcomes of Anemia in Geriatrics: A Systematic Review of the Literature. Am J Med. 2004; 116(7A): 3–10.
55. Gaskell H., Derry S., Moore R.A., McQuay H.J. Prevalence of anemia in older persons: systematic review. BMC Geriatrics. 2008; 8: 1.
56. Yeap B.B., Alfonso H., Chubb S.A., Walsh J.P., Hankey G.J., Almeida O.P., Flicker L. Higher free tyroxine levels are associated with frailty in older men: the Health in Men Study. Clin Endocrinol (Oxf). 2012 May; 76(5): 741–827.
57. Maxwell C.A., Yu F. Biological Processes and Biomarkers Related to Frailty in Older Adults: A State-of-the-Science Literature Review. 2018; 9:1099800418798047.
58. Ritt M., Jäger J., Ritt J.I. et al. Operationalizing a frailty index using routine blood and urine tests. Clin Interv Aging. 2017; 12: 1029–1040.
59. Feng Z., Lugtenberg M., Franse C. et al. Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies. PLoS One. 2017; 12(6): e0178383.
60. Bjelakovic G., Gluud L.L., Nikolova D., Whitfield К., Wetterslev J., Simonetti R.G., Bjelakovic M., Gluud C. Vitamin D supplementation for prevention of mortality in adults (Review). The Cochrane Library 2014; CD007470. DOI: 10.1002/14651858.CD007470.pub3.
61. Rubenstein L.Z., Josephson K.R., Wieland G.D., English P.A., Sayre J.A., Kane R.L. Effectiveness of a geriatric evaluation unit. A randomized clinical trial. N Engl J Med.1984; 311(26): 1664–70.
62. Bachmann S., Finger C., Huss A., Egger M., Stuck A.E., Clough-Gorr K.M. Inpatient rehabilitation specifically designed for geriatric patients: systematic review and meta-analysis of randomised controlled trials. BMJ. 2010; 340: 1718.
63. Clarke R. et al. Screening for vitamin B–12 and folate deficiency in older persons. Am. J. Clin. Nutr. 2003; 77: 1241–1247.
64. Gould D. et al. Visual Analogue Scale (VAS). Journal of Clinical Nursing. 2001; 10: 697–706.
65. Huskisson E.C. Measurement of pain. Lancet. 1974; 2: 1127–31.
66. Downie W.W., Leatham P.A., Rhind V.M., Wright V., Branco J.A., Anderson J.A. Studies with pain rating scales. Ann Rheum Dis. 1978; 37: 378–81.
67. Scott J., Huskisson E.C. Graphic representation of pain. Pain. 1976; 2: 175–84.
68. Joos E., Peretz A., Beguin S., et al. Reliability and reproducibility of visual analogue scale and numeric rating scale for therapeutic evaluation of pain in rheumatic patients. J Rheumatol 1991; 18: 1269–70.
69. Warden V., Hurley A.C., Volicer L. Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale. J Am Med Dir Assoc. 2003; 4(1): 9–15.
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For citations:
Tkacheva O.N., Kotovskaya Yu.V., Runikhina N.K., Frolova E.V., Naumov A.V., Vorobyeva N.M., Ostapenko V.S., Mkhitaryan E.A., Sharashkina N.V., Tyukhmenev E.A., Pereverzev A.P., Dudinskaya E.N. Clinical guidelines frailty. Part 2. Russian Journal of Geriatric Medicine. 2020;(2):115-130. (In Russ.) https://doi.org/10.37586/2686-8636-2-2020-115-130
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