White Matter Hyperintensities According to Neuroimaging Analysis, Cognitive Impairment and Emotional Disorders: Is There a Link?
https://doi.org/10.37586/2686-8636-2-2023-121-126
Abstract
Background. Cognitive decline is one of leading contributors to the loss of independence in older adults. Therefore, early diagnosis and detection of potentially modifiable cognitive disorders is a significant challenge for modern geriatrics.
Aim. To assess the relationship between cognitive impairment and presence of leukoareosis through neuroimaging in older adults.
Materials and methods. General population cohort study of 102 patients aged 60–98 years treated at The St. Petersburg Hospital for War Veterans between September and December 2019. Cognitive assessment (The Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE)), depression (The Geriatric Depression Scale), sleep complaints, subjective cognitive decline, computed tomography (CT) scan.
Results. The studied patients were divided into two groups: with the presence of leukoareosis (n=59) and without leukoareosis (n=43). Patients with leukoareosis had significantly lower total MoCA scores. They performed significantly worse in domains of visual–structural skills and attention. As for MMSE, patients with leukoareosis also performed significantly worse in repeating a sentence and descending subtraction task. There was no statistically significant difference in GDS scores between the two groups. However, patients with leukoareosis significantly more frequently considered their lives less fulfilling and their memory worse. They also abandoned most of their former interests.
Conclusion. If leukoareosis is detected on CT scans, it is necessary to evaluate cognitive functions; the presence of leukoareosis in patients was associated with an increased risk of cognitive disorders and depression.
About the Authors
A. A. Govorushina
The North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Govorushina Anastasia A., 6th year student, the Faculty of General Medicine
Saint Petersburg
S. M. Minakova
The North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Minakova Margarita S., 6th year student, the Faculty of General Medicine
Saint Petersburg
A. D. Kalmykova
The North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Kalmykova Anastasia D., 6th year student, the Faculty of General Medicine
Saint Petersburg
A. V. Turusheva
The North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Turusheva Anna V., MD, PhD, Associate Professor, Department of Family Medicine
Saint Petersburg
T. A. Bogdanova
The North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Bogdanova Tatiana A., Assistant Professor, the Department of Family Medicine
Saint Petersburg
References
1. Heiss W.D., Rosenberg G.A., Thiel A., Berlot R., de Reuck J. Neuroimaging in vascular cognitive impairment: a state-of-the-art review. BMC Med. 2016;14(1):174 DOI: 10.1186/s12916-016-0725-0.
2. Chen Y., Wang X., Guan L., Wang Y. Role of White Matter Hyperintensities and Related Risk Factors in Vascular Cognitive Impairment: A Review. Biomolecules 2021;11: 1102. https://doi.org/10.3390/biom11081102
3. Wardlaw J.M., Valdés Hernández M.C., Muñoz-Maniega S. What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc. 2015;4(6):001140. Published 2015 Jun 23. DOI: 10.1161/JAHA.114.001140.
4. Tubi M.A., Feingold F.W., Kothapalli D., Hare E.T., et al. White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm. Neuroimage. 2020 Feb 1;206:116327. DOI: 10.1016/j.neuroimage.2019.116327.
5. Moroni F., Ammirati E., Rocca M.A., Filippi M., et al. Cardiovascular disease and brain health: Focus on white matter hyperintensities.Int J Cardiol Heart Vasc. 2018 Jun; 19: 63–69. DOI: 10.1016/j.ijcha.2018.04.006.
6. Qi X., Tang H., Luo Q., Ding B., et al. White Matter Hyperintensities Predict Cognitive Decline: A Community-Based Study. Can J Neurol Sci. and Subsequent Cognitive Impairment. Neurosci. Bull. June, 2019;46(4):383–388. DOI:10.1017/cjn.2019.47.
7. Zhu W., Huang H., Yang S., Luo X., et al. Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities 2021;37(6):789–803 DOI:10.1007/s12264-021-00657-0.
8. Liu Y., Xia Y., Wang X., Wang Y., et al. White matter hyperintensities induce distal deficits in the connected fibers. Hum Brain Mapp. 2021;42:1910–1919. DOI: 10.1002/hbm.25338.
9. Ermolaeva AI, Baranova GA, Nesterenko TA, Kokareva EA. Metody nejrovizualizacii pri ostryh narushenijah mozgovogo krovoobrashhenija u bol'nyh saharnym diabetom 2-ogo tipa. Medicinskij Al'manah. 2017;5(50):36–39.(In Russ).
10. Semenova NV, pod obshh. red. Neznanova NG. Diagnostika i lechenie psihicheskih i narkologicheskih rasstrojstv: sovremennye podhody. Sbornik metodicheskih rekomendacij. SPb.: Izdatel'sko-poligraficheskaja kompanija “KOSTA”; 2018: 448 s.
11. Klinicheskie rekomendacii: “Kognitivnye rasstrojstva u lic pozhilogo i starcheskogo vozrasta”; 2020: 311s.
12. Emelin AJu, Lobzin VJu, Vorob’ev SV. Kognitivnye narushenija: rukovodstvo dlja vrachej — Moskva, 2019. — 416 s.: il.
13. Jia X., Wang Z., Huang F., Su C., et al. A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a crosssectional study Jia et al. BMC Psychiatry. 2021; 21:485 DOI:10.1186/s12888-021-03495-6.
14. Solov’eva AP, Gorjachev DV, Arhipov VV. Kriterii ocenki kognitivnyh narushenij v klinicheskih issledovanijah. Vedomosti Nauchnogo centra jekspertizy sredstv medicinskogo primenenija. 2018;8(4):218–230. https://doi.org/10.30895/1991-2919-2018-8-4-218-230
15. Fang Y., Qin T., Liu W., Ran L., et al. Cerebral Small-Vessel Disease and Risk of Incidence of Depression: A Meta-Analysis of Longitudinal Cohort Studies. J Am Heart Assoc. 2020;9:e016512. DOI: 10.1161/JAHA.120.016512.
16. Rushia S.N., Shehab A.A.S., Motter J.N., Egglefield D.A., et al. Vascular depression for radiology: A review of the construct, methodology, and diagnosis. World J Radiol 2020; 12(5): 48–67. DOI: 10.4329/wjr.v12.i5.48.
17. Thurston R.C., Wu M., Aizenstein H.J., Chang Y., Mitchell E.B., et al. Sleep characteristics and white matter hyperintensities among midlife women. SLEEPJ. 2020; 43(6):1–7. DOI: 10.1093/sleep/zsz298.
Review
For citations:
Govorushina A.A., Minakova S.M., Kalmykova A.D., Turusheva A.V., Bogdanova T.A. White Matter Hyperintensities According to Neuroimaging Analysis, Cognitive Impairment and Emotional Disorders: Is There a Link? Russian Journal of Geriatric Medicine. 2023;(2):121-126. (In Russ.) https://doi.org/10.37586/2686-8636-2-2023-121-126
Views:
1022
Email this article 