geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-4-2020-333-338geriatr-87Research ArticleОБЗОРЫREVIEWSОбзор полиморфизма генов, связанных с сердечно-сосудистыми заболеваниямиReview of polymorphisms, associated with cardiovascular diseaseshttps://orcid.org/0000-0002-2362-9798АкопянА. А.AkopyanA. A.

Акопян Анна Александровна, младший научный сотрудник лаборатории трансляционных исследований в геронтологии

Москва

телефон: +7(903)745-57-88

MD, Junior researcher, laboratory of translational gerontology

Moscow

a.alexandrova18@gmail.comhttps://orcid.org/0000-0002-3657-0676СтражескоИ. Д.StrazheskoI. D.

Стражеско Ирина Дмитриевна, д-р мед. наук, заместитель директора по трансляционной медицине;

Ведущий научный сотрудник отдела возраст-ассоциированных заболеваний

Москва

телефон: +7(903)520-41-54

MD, PhD, Deputy Director of translational medicine;

Leading Researcher at the Department of Agerelated diseases

Moscow

istrazhesko@gmail.comhttps://orcid.org/0000-0002-4193-688XТкачеваО. Н.TkachevaO. N.

Ткачева Ольга Николаевна, д-р мед. наук, профессор, директор Российского геронтологического научно-клинический центра

Москва

телефон: +7(499)187-64-67

MD, PhD, professor, Director

Moscow

tkacheva@rgnkc.ruhttps://orcid.org/0000-0002-4756-0342ЕсаковаА. П.YesakovaA. P.

Есакова Антонина Павловна, младший научный сотрудник лаборатории трансляционных исследований в геронтологии;

Ассистент кафедры медицинской генетики

Москва

телефон: +7(906)702-07-13

MD, Junior researcher at laboratory of translational gerontology;

Assistant of the department of medical genetics

Moscow

a.yesakova@gmail.comhttps://orcid.org/0000-0002-8160-5612ОрловаЯ. А.OrlovaI. A.

Орлова Яна Артуровна, д-р мед. наук, профессор, руководитель отдела возраст-ассоциированных заболеваний

Москва

телефон: +7(495)531-27-77, доб. 2100

MD, PhD, Professor, Head of the Department of Age-associated diseases

Moscow

5163002@bk.ruФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical CentreRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр; Медицинский Научно-Образовательный Центр Московского государственного университета им. М.В. ЛомоносоваРоссияPirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre; Medical Scientific and Educational Center of Lomonosov Moscow State UniversityRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр; ФГБУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»РоссияPirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre; Moscow State University of Medicine and DentistryRussian FederationМедицинский Научно-Образовательный Центр Московского государственного университета им. М.В. ЛомоносоваРоссияMedical Scientific and Educational Center of Lomonosov Moscow State UniversityRussian Federation20200301202104333338Copyright © Акопян А.А., Стражеско И.Д., Ткачева О.Н., Есакова А.П., Орлова Я.А., 20212021Акопян А.А., Стражеско И.Д., Ткачева О.Н., Есакова А.П., Орлова Я.А.Akopyan A.A., Strazhesko I.D., Tkacheva O.N., Yesakova A.P., Orlova I.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/87

В последние годы растет количество работ, изучающих влияние полиморфизма генов на риски развития сердечно-сосудистых заболеваний. В статье представлен обзор исследований аллельных вариантов генов, кодирующих белки, участвующие в активации ренинангиотензин-альдостероновой системы (полиморфизм c.521C>T гена AGT и полиморфизм Ins>Del гена ACE), продукции оксида азота (полиморфизм c.894G>T гена NOS3), хроническом воспалении (полиморфизм -238G>A гена TNF и полиморфизм -1562С>T гена MMP9) и окислительном стрессе (полиморфизм c.214Т>С гена CYBA), и их связь с факторами риска и сердечно-сосудистыми заболеваниями.

In this research we examined studies of gene polymorphisms, associated with cardiovascular diseases through renin-angiotensin-aldosterone system activation (AGT с.521С>Т, AСE Ins>Del), nitric oxide decline (NOS3 с.894G>T), chronic inflammation (TNF -238G>A, MMP9 -1562С>T) and oxidative stress (CYBA c.214Т>С).

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The authors declare that there are no conflicts of interest present.