geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-1-2020-74-80geriatr-8Research ArticleОБЗОРЫREVIEWSСосудистое старение у пациентов пожилого возраста с метаболическим синдромомVascular ageing in elderly patients with metabolic syndromehttps://orcid.org/0000-0001-5981-1754НедогодаС. В.NedogodaS. V.

Недогода Сергей Владимирович  — д-р мед. наук, профессор, заведующий кафедрой терапии и  эндокринологии факультета усовершенствования врачей 

тел. +7(8442) 97-42-51

SPIN-код: 7005-7846

S.V. Nedogoda, MD, PhD, professor, Head of Internal Diseases and Endocrinology Departament

+7(8442) 97-42-51

SPIN-код: 7005-7846

nedogodasv@rambler.ruhttps://orcid.org/0000-0002-0662-1217ЦомаВ. В.TsomaV. V.

Цома Вера Владимировна  — канд. мед. наук, доцент кафедры терапии и  эндокринологии факультета усовершенствования врачей

телефон: +7(917) 833-27-76 

SPIN-код: 4918-3790

V.V. Tsoma, MD, PhD, associate professor, Internal Diseases and Endocrinology Department

+7(917) 833-27-76

SPIN-код: 4918-3790

vtsoma38@gmail.comhttps://orcid.org/0000-0002-6740-8321ЧумачекЕ. В.ChumachekE. V.

Чумачек Елена Валерьевна  — канд. мед. наук, ассистент кафедры терапии и  эндокринологии факультета усовершенствования врачей

телефон: +7(917) 339-1384 

SPIN-код: 6298-2220

E.V. Chumachek, MD, PhD, associate professor, Internal medicine and endocrinology Departament

+7(917) 339-1384

SPIN-код: 6298-2220

elena-chumachek@yandex.ruhttps://orcid.org/0000-0002-0646-5824СмирноваВ. О.SmirnovaV. O.

Смирнова Виктория Олеговна  — ассистент кафедры терапии и  эндокринологии факультета усовершенствования врачей

телефон: +7(902) 096-44-65

SPIN-код: 4601-9910

V.O. Smirnova, assistant fellow, Internal Diseases and Endocrinology Departament

+7(902) 096-44-65

SPIN-код: 4601-9910

3asabird@inbox.ruhttps://orcid.org/0000-0003-3285-4265ПалашкинР. В.PalashkinR. V.

Палашкин Роман Витальевич — аспирант кафедры терапии и эндокринологии факультета усовершенствования врачей

телефон: +7(927) 538-6971

SPIN-код: 6481-1370

R.V. Palashkin, PhD-student, Internal Diseases and Endocrinology Departament

+7(927) 538-6971

SPIN-код: 6481-1370

oldgodlor@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияVolgograd State Medical University, Department of Therapy and Endocrinology of the Faculty of Medical ExcellenceRussian Federation202022022020017480Copyright © Недогода С.В., Цома В.В., Чумачек Е.В., Смирнова В.О., Палашкин Р.В., 20202020Недогода С.В., Цома В.В., Чумачек Е.В., Смирнова В.О., Палашкин Р.В.Nedogoda S.V., Tsoma V.V., Chumachek E.V., Smirnova V.O., Palashkin R.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/8

Старение сосудов связано с увеличением артериальной жесткости, ремоделированием сосудов, а также с увеличением скорости распространения пульсовой волны. Этот процесс может быть ускорен кумулятивным воздействием различных факторов, которые повреждают артериальную стенку: артериальная гипертензия, гипергликемия, дислипидемия, курение и т.д. В настоящее время отсутствуют убедительные данные о преимущественном влиянии тех или иных компонентов метаболического синдрома, оказывающих наибольшее влияние на ускорение сосудистого старения у пациентов пожилого возраста. В связи с этим было проведено неинтервенционное исследование, целью которого стал расчет сосудистого возраста и его сопоставление с паспортным у пациентов старше 65 лет с метаболическим синдромом (МС) и ожирением, с оценкой наибольшего вклада в сосудистое старение в данной возрастной группе различных компонентов МС. Проведенное исследование показало, что в разные возрастные периоды компоненты МС имеют различный удельный вес в формировании раннего сосудистого старения.

Vascular aging is associated with increased arterial stiffness, vascular remodeling, and increased pulse wave propagation rate. This process can be accelerated by cumulative exposure to various factors that damage the arterial wall: arterial hypertension, hyperglycemia, dyslipidemia, smoking, etc. At present, there is no convincing evidence of the preferential effect of certain components of metabolic syndrome that have the greatest impact on the acceleration of vascular aging in older patients. In  this regard, a  non-interactive study was conducted to  calculate vascular age and compare it with passport age in patients over 65 years of age with metabolic syndrome (MS) and obesity, assessing the greatest contribution to vascular ageing in a given age group of different MS components. The study showed that at different age periods MS components have different specific weights in the formation of early vascular aging.

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The authors declare that there are no conflicts of interest present.