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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-2-2026-208-218</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-751</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Основные положения Методических рекомендаций по ведению пациентов пожилого и старческого возраста с остеоартритом</article-title><trans-title-group xml:lang="en"><trans-title>The main provisions of the Methodological recommendations of management of patients in the elderly with osteoarthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-1831-0588</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Унковский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Unkovskiy</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Унковский Алексей Владимирович</p><p>Москва</p></bio><bio xml:lang="en"><p>Aleksey Vladimirovich Unkovskiy</p><p>Moscow</p></bio><email xlink:type="simple">unkovsky_av@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8575-2015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фокеев</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Fokeev</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6253-621X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3066-4866</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ховасова</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Khovasova</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр»<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation (Pirogov University), Russian Gerontological Research and Clinical Center<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр»; Кафедра болезней старения ИНОПР ФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава России (Пироговский Университет)<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation (Pirogov University), Russian Gerontological Research and Clinical Center; Department of Aging Diseases, Institute of Educational, Methodological and Pedagogical Problems, Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation (Pirogov University)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>25</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>2</issue><fpage>208</fpage><lpage>218</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Унковский А.В., Фокеев Д.К., Наумов А.В., Ховасова Н.О., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Унковский А.В., Фокеев Д.К., Наумов А.В., Ховасова Н.О.</copyright-holder><copyright-holder xml:lang="en">Unkovskiy A.V., Fokeev D.K., Naumov A.V., Khovasova N.O.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/751">https://www.geriatr-news.com/jour/article/view/751</self-uri><abstract><p>В данной статье нами изложены основные положения, касающиеся эпидемиологии, клинических особенностей, диагностических и лечебных мероприятий в отношении остеоартрита, ранее опубликованных в Методических рекомендациях. Подготовленная нами информация направлена на оптимизацию и индивидуализацию ведения пациентов 60 лет и старше с остеоартритом.</p></abstract><trans-abstract xml:lang="en"><p>In this article, we present key provisions regarding epidemiology, clinical features, diagnosis and treatment for osteoarthritis as previously published in Methodological Recommendations. We have prepared information aimed at optimizing and personalizing the treatment of patients aged 60 and older with osteoarthritis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>болевой синдром</kwd><kwd>пациенты пожилого возраста</kwd><kwd>коморбидность</kwd><kwd>гериатрические синдромы</kwd><kwd>саркопения</kwd><kwd>невропатическая боль</kwd><kwd>другие нестероидные противовоспалительные и противоревматические препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>pain syndrome</kwd><kwd>elderly patients</kwd><kwd>comorbidity</kwd><kwd>geriatric syndromes</kwd><kwd>sarcopenia</kwd><kwd>neuropathic pain</kwd><kwd>other non-steroidal anti-inflammatory and antirheumatic drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов А. В., Ховасова Н. О., Мешков А. Д. и др. Ведение пациентов пожилого возраста с остеоартритом (Методические рекомендации Российской ассоциации геронтологов и гериатров) // Российский журнал гериатрической медицины. — 2025. — № 2. — С. 125–144.</mixed-citation><mixed-citation xml:lang="en">Naumov A. V., Xovasova N. O., Meshkov A. D., et al. Management of patients in the elderly with osteoarthritis (Methodological recommendations of the Russian Association of Gerontologists and Geriatricians). Russian Journal of Geriatric Medicine. 2025 ; (2) : 125–144. (In Russ.). DOI: 10.37586/2686-8636-2-2025-125-144.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов А. В., Воробьёва Н. М., Ховасова Н. О. и др. Распространенность остеоартрита и его ассоциации с гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ // Терапевтический архив. — 2021. — Т. 93, № 12. — C. 1482–1490.</mixed-citation><mixed-citation xml:lang="en">Naumov A. V., Vorobyeva N. M., Khovasova N. O., et al. The prevalence of osteoarthritis and its association with geriatric syndromes in people over 65: data from the Russian epidemiological study EVKALIPT. Terapevticheskii arkhiv. 2021 ; 93 (12) : 1482–1490. (In Russ.). DOI: 10.26442/00403660.20 21.12.201268.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese N., Honvo G., Bruyère O., et al. Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies. Aging Clin Exp Res. 2023 ; 35 (2) : 245–252. DOI: 10.1007/s40520-022-02289-4.</mixed-citation><mixed-citation xml:lang="en">Veronese N., Honvo G., Bruyère O., et al. Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies. Aging Clin Exp Res. 2023 ; 35 (2) : 245–252. DOI: 10.1007/s40520-022-02289-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ritsuno Y., Kawado M., Morita M., et al. Impact of musculoskeletal disorders on healthy life expectancy in Japan. BMC Musculoskelet Disord. 2021 ; 22 (1) : 661. DOI: 10.1186/s12891-021-04539-4.</mixed-citation><mixed-citation xml:lang="en">Ritsuno Y., Kawado M., Morita M., et al. Impact of musculoskeletal disorders on healthy life expectancy in Japan. BMC Musculoskelet Disord. 2021 ; 22 (1) : 661. DOI: 10.1186/s12891-021-04539-4.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Liao J., Yu X., Chen J., et al. Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis. Front Immunol. 2023 ; 14 : 1063018. DOI: 10.3389/fimmu.2023.1063018.</mixed-citation><mixed-citation xml:lang="en">Liao J., Yu X., Chen J., et al. Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis. Front Immunol. 2023 ; 14 : 1063018. DOI: 10.3389/fimmu.2023.1063018.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Musumeci G., Castrogiovanni P., Trovato F. M., et al. Microscopic and macroscopic anatomical features in healthy and osteoarthritic knee cartilage. OA Anatomy. 2013 ; 1 (3) : 30.</mixed-citation><mixed-citation xml:lang="en">Musumeci G., Castrogiovanni P., Trovato F. M., et al. Microscopic and macroscopic anatomical features in healthy and osteoarthritic knee cartilage. OA Anatomy. 2013 ; 1 (3) : 30.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ramasamy T. S., Yee Y. M., Khan I. M. Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities. Front Cell Dev Biol. 2021 ; 9 : 625497. DOI: 10.3389/fcell.2021.625497.</mixed-citation><mixed-citation xml:lang="en">Ramasamy T. S., Yee Y. M., Khan I. M. Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities. Front Cell Dev Biol. 2021 ; 9 : 625497. DOI: 10.3389/fcell.2021.625497.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Korochina K. V., Chernysheva T. V., Korochina I. E. Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination. Russian Open Medical Journal. 2021 ; 10 (3) : e0312. DOI: 10.15275/rusomj.2021.0312.</mixed-citation><mixed-citation xml:lang="en">Korochina K. V., Chernysheva T. V., Korochina I. E. Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination. Russian Open Medical Journal. 2021 ; 10 (3) : e0312. DOI: 10.15275/rusomj.2021.0312.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Swain S., Sarmanova A., Coupland C., et al. Comorbidities in Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Arthritis Care Res (Hoboken). 2020 ; 72 (7) : 991–1000. DOI: 10.1002/acr.24008.</mixed-citation><mixed-citation xml:lang="en">Swain S., Sarmanova A., Coupland C., et al. Comorbidities in Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Arthritis Care Res (Hoboken). 2020 ; 72 (7) : 991–1000. DOI: 10.1002/acr.24008.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lindéus M., Turkiewicz A., Englund M., Kiadaliri A. Socioeconomic inequalities in all-cause and cause-specific mortality among patients with osteoarthritis in the Skåne region of Sweden. Arthritis Care Res. 2022 ; 74 (10) : 1704–1712. DOI: 10.1002/acr.24613.</mixed-citation><mixed-citation xml:lang="en">Lindéus M., Turkiewicz A., Englund M., Kiadaliri A. Socioeconomic inequalities in all-cause and cause-specific mortality among patients with osteoarthritis in the Skåne region of Sweden. Arthritis Care Res. 2022 ; 74 (10) : 1704–1712. DOI: 10.1002/acr.24613.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Yeh C. H., Chang W. L., Chan P. C, et al. Women With Osteoarthritis Are at Increased Risk of schemic Stroke: A Population-Based Cohort Study. J Epidemiol. 2021 ; 31 (12) : 628–634. DOI: 10.2188/jea.JE20200042.</mixed-citation><mixed-citation xml:lang="en">Yeh C. H., Chang W. L., Chan P. C, et al. Women With Osteoarthritis Are at Increased Risk of schemic Stroke: A Population-Based Cohort Study. J Epidemiol. 2021 ; 31 (12) : 628–634. DOI: 10.2188/jea.JE20200042.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Constantino de Campos G., Mundi R., Whittington C., et al. Osteoarthritis, mobility-related comorbidities and mortality: an overview of meta-analyses. Ther Adv Musculoskelet Dis. 2020 ; 12 : 1759720X20981219. DOI: 10.1177/1759720X20981219.</mixed-citation><mixed-citation xml:lang="en">Constantino de Campos G., Mundi R., Whittington C., et al. Osteoarthritis, mobility-related comorbidities and mortality: an overview of meta-analyses. Ther Adv Musculoskelet Dis. 2020 ; 12 : 1759720X20981219. DOI: 10.1177/1759720X20981219.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Liu W., Ma W., Liu H., et al. Stroke risk in arthritis: A systematic review and meta-analysis of cohort studies. PLoS One. 2021 ; 16 (3) : e0248564. DOI: 10.1371/journal.pone.0248564.</mixed-citation><mixed-citation xml:lang="en">Liu W., Ma W., Liu H., et al. Stroke risk in arthritis: A systematic review and meta-analysis of cohort studies. PLoS One. 2021 ; 16 (3) : e0248564. DOI: 10.1371/journal.pone.0248564.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Valdes A. M., Stocks J. Osteoarthritis and Ageing. EMJ. 2018 ; 3 (1) : 116–123. DOI: 10.33590/emj/10313855.</mixed-citation><mixed-citation xml:lang="en">Valdes A. M., Stocks J. Osteoarthritis and Ageing. EMJ. 2018 ; 3 (1) : 116–123. DOI: 10.33590/emj/10313855.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cacciatore F., Della-Morte D., Basile C., et al. Longterm mortality in frail elderly subjects with osteoarthritis. Rheumatology (Oxford). 2014 ; 53 (2) : 293–9299. DOI: 10.1093/rheumatology/ket348.</mixed-citation><mixed-citation xml:lang="en">Cacciatore F., Della-Morte D., Basile C., et al. Longterm mortality in frail elderly subjects with osteoarthritis. Rheumatology (Oxford). 2014 ; 53 (2) : 293–9299. DOI: 10.1093/rheumatology/ket348.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Doré A. L., Golightly Y. M., Mercer V. S., et al. Lowerextremity osteoarthritis and the risk of falls in a communitybased longitudinal study of adults with and without osteoarthritis. Arthritis Care Res (Hoboken). 2015 ; 67 (5) : 633–639. DOI: 10.1002/acr.22499.</mixed-citation><mixed-citation xml:lang="en">Doré A. L., Golightly Y. M., Mercer V. S., et al. Lowerextremity osteoarthritis and the risk of falls in a communitybased longitudinal study of adults with and without osteoarthritis. Arthritis Care Res (Hoboken). 2015 ; 67 (5) : 633–639. DOI: 10.1002/acr.22499.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese N., Stubbs B., Solmi M., et al. Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative. Age and Ageing. 2017 ; 46 (3) : 470–476. DOI: 10.1093/ageing/afw216.</mixed-citation><mixed-citation xml:lang="en">Veronese N., Stubbs B., Solmi M., et al. Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative. Age and Ageing. 2017 ; 46 (3) : 470–476. DOI: 10.1093/ageing/afw216.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada K., Kubota Y., Tabuchi T., et al. A prospective study of knee pain, low back pain, and risk of dementia: the JAGES project. Sci Rep. 2019 ; 9 (1) : 10690. DOI: 10.1038/s41598-019-47005-x.</mixed-citation><mixed-citation xml:lang="en">Yamada K., Kubota Y., Tabuchi T., et al. A prospective study of knee pain, low back pain, and risk of dementia: the JAGES project. Sci Rep. 2019 ; 9 (1) : 10690. DOI: 10.1038/s41598-019-47005-x.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hanlon P., Nicholl B. I., Jani B. D., et al. Frailty and prefrailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants. Lancet Public Health. 2018 ; 3 (7) : e323–e332. DOI: 10.1016/S2468-2667(18)30091-4.</mixed-citation><mixed-citation xml:lang="en">Hanlon P., Nicholl B. I., Jani B. D., et al. Frailty and prefrailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants. Lancet Public Health. 2018 ; 3 (7) : e323–e332. DOI: 10.1016/S2468-2667(18)30091-4.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hoops M., Rosenblatt N., Hurt C., et al. Does lower extremity osteoarthritis exacerbate risk factors for falls in older adults? Womens Health (Lond). 2012 ; 8 (6) : 685–698. DOI: 10.2217/whe.12.53.</mixed-citation><mixed-citation xml:lang="en">Hoops M., Rosenblatt N., Hurt C., et al. Does lower extremity osteoarthritis exacerbate risk factors for falls in older adults? Womens Health (Lond). 2012 ; 8 (6) : 685–698. DOI: 10.2217/whe.12.53.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Barbour K. E., Stevens J. A., Helmick C. G., et al. Falls and fall injuries among adults with arthritis — United States, 2012. MMWR Morb Mortal WklyRep. 2014 ; 63 (17) : 379–383.</mixed-citation><mixed-citation xml:lang="en">Barbour K. E., Stevens J. A., Helmick C. G., et al. Falls and fall injuries among adults with arthritis — United States, 2012. MMWR Morb Mortal WklyRep. 2014 ; 63 (17) : 379–383.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hana S., Aicha B. T., Selim D., et al. Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients. Curr Rheumatol Rev. 2018 ; 14 (2) : 181–187. DOI: 10. 2174/1573397113666170425150133.</mixed-citation><mixed-citation xml:lang="en">Hana S., Aicha B. T., Selim D., et al. Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients. Curr Rheumatol Rev. 2018 ; 14 (2) : 181–187. DOI: 10. 2174/1573397113666170425150133.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolic G., Nedeljkovic B., Trajkovic G., et al. Pain, Physical Function, Radiographic Features, and Quality of Life in Knee Osteoarthritis Agricultural Workers Living in Rural Population. Pain Res Manag. 2019 ; 2019 : 7684762. DOI: 10.1155/2019/7684762.</mixed-citation><mixed-citation xml:lang="en">Nikolic G., Nedeljkovic B., Trajkovic G., et al. Pain, Physical Function, Radiographic Features, and Quality of Life in Knee Osteoarthritis Agricultural Workers Living in Rural Population. Pain Res Manag. 2019 ; 2019 : 7684762. DOI: 10.1155/2019/7684762.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Foley S. J., Lord S. R., Srikanth V., et al. Falls risk is associated with pain and dysfunction but not radiographic osteoarthritis in older adults: Tasmanian Older Adult Cohort study. Osteoarthritis Cartilage. 2006 ; 14 (6) : 533–539. DOI: 10.1016/j.joca.2005.12.007.</mixed-citation><mixed-citation xml:lang="en">Foley S. J., Lord S. R., Srikanth V., et al. Falls risk is associated with pain and dysfunction but not radiographic osteoarthritis in older adults: Tasmanian Older Adult Cohort study. Osteoarthritis Cartilage. 2006 ; 14 (6) : 533–539. DOI: 10.1016/j.joca.2005.12.007.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">De Ceuninck F., Fradin A., Pastoureau P. Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together. Drug Discov Today. 2014 ; 19 (3) : 305–311. DOI: 10.1016/j.drudis.2013.08.004.</mixed-citation><mixed-citation xml:lang="en">De Ceuninck F., Fradin A., Pastoureau P. Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together. Drug Discov Today. 2014 ; 19 (3) : 305–311. DOI: 10.1016/j.drudis.2013.08.004.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Alexandre T. D. S., Duarte Y. A. O., Santos J. L. F., Lebrão M. L. Prevalência e fatores associados à sarcopenia, dinapenia e sarcodinapenia em idosos residentes no Município de São Paulo — Estudo SABE. [Prevalence and associated factors of sarcopenia, dynapenia, and sarcodynapenia in communitydwelling elderly in São Paulo — SABE Study. Rev Bras Epidemiol. 2019 ; 21Suppl 02 (Suppl 02) : e180009. DOI: 10.1590/1980-549720180009.supl.2.</mixed-citation><mixed-citation xml:lang="en">Alexandre T. D. S., Duarte Y. A. O., Santos J. L. F., Lebrão M. L. Prevalência e fatores associados à sarcopenia, dinapenia e sarcodinapenia em idosos residentes no Município de São Paulo — Estudo SABE. [Prevalence and associated factors of sarcopenia, dynapenia, and sarcodynapenia in communitydwelling elderly in São Paulo — SABE Study. Rev Bras Epidemiol. 2019 ; 21Suppl 02 (Suppl 02) : e180009. DOI: 10.1590/1980-549720180009.supl.2.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lee K., Shin Y., Huh J., et al. Recent Issues on Body Composition Imaging for Sarcopenia Evaluation. Korean J Radiol. 2019 ; 20 (2) : 205–217. DOI: 10.3348/kjr.2018.0479.</mixed-citation><mixed-citation xml:lang="en">Lee K., Shin Y., Huh J., et al. Recent Issues on Body Composition Imaging for Sarcopenia Evaluation. Korean J Radiol. 2019 ; 20 (2) : 205–217. DOI: 10.3348/kjr.2018.0479.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen B. K., Fischer C. P. Beneficial health effects of exercise — the role of IL-6 as a myokine. Trends Pharmacol Sci. 2007; 28 (4) : 152–156. DOI: 10.1016/j.tips.2007.02.002.</mixed-citation><mixed-citation xml:lang="en">Pedersen B. K., Fischer C. P. Beneficial health effects of exercise — the role of IL-6 as a myokine. Trends Pharmacol Sci. 2007; 28 (4) : 152–156. DOI: 10.1016/j.tips.2007.02.002.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly M., Gauthier M. S., Saha A. K., Ruderman N. B. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 2009 ; 58 (9 ): 1953–1960. DOI: 10.2337/db08-1293.</mixed-citation><mixed-citation xml:lang="en">Kelly M., Gauthier M. S., Saha A. K., Ruderman N. B. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 2009 ; 58 (9 ): 1953–1960. DOI: 10.2337/db08-1293.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Morley J. E. Sarcopenia in the elderly. Fam Pract. 2012 ; 29 (suppl. 1): i44–i48. DOI: 10.1093/fampra/cmr063.</mixed-citation><mixed-citation xml:lang="en">Morley J. E. Sarcopenia in the elderly. Fam Pract. 2012 ; 29 (suppl. 1): i44–i48. DOI: 10.1093/fampra/cmr063.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sampson E. L., White N., Lord K., et al. Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: a longitudinal cohort study. Pain. 2015 ; 156 (4) : 675–683. DOI: 10.1097/j.pain.0000000000000095.</mixed-citation><mixed-citation xml:lang="en">Sampson E. L., White N., Lord K., et al. Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: a longitudinal cohort study. Pain. 2015 ; 156 (4) : 675–683. DOI: 10.1097/j.pain.0000000000000095.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rajkumar A. P., Ballard C., Fossey J., et al. Epidemiology of Pain in People With Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications. J Am Med Dir Assoc. 2017 ; 18 (5) : 453.e1–453.e6. DOI: 10.1016/j.jamda.2017.01.024.</mixed-citation><mixed-citation xml:lang="en">Rajkumar A. P., Ballard C., Fossey J., et al. Epidemiology of Pain in People With Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications. J Am Med Dir Assoc. 2017 ; 18 (5) : 453.e1–453.e6. DOI: 10.1016/j.jamda.2017.01.024.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Meraya A. M., Dwibedi N., Sambamoorthi U. Polypharmacy and Health-Related Quality of Life Among US Adults With Arthritis, Medical Expenditure Panel Survey, 2010–2012. Prev Chronic Dis. 2016 ; 13 : E132. DOI: 10.5888/pcd13.160092.</mixed-citation><mixed-citation xml:lang="en">Meraya A. M., Dwibedi N., Sambamoorthi U. Polypharmacy and Health-Related Quality of Life Among US Adults With Arthritis, Medical Expenditure Panel Survey, 2010–2012. Prev Chronic Dis. 2016 ; 13 : E132. DOI: 10.5888/pcd13.160092.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Whitlock E. L., Diaz-Ramirez L. G., Glymour M. M., et al. Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders. JAMA Intern Med. 2017 ; 177 (8) : 1146–1153. DOI: 10.1001/jamainternmed.2017.1622.</mixed-citation><mixed-citation xml:lang="en">Whitlock E. L., Diaz-Ramirez L. G., Glymour M. M., et al. Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders. JAMA Intern Med. 2017 ; 177 (8) : 1146–1153. DOI: 10.1001/jamainternmed.2017.1622.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pitcher M. H., Von Korff M., Bushnell M. C., Porter L. Prevalence and Profile of High-Impact Chronic Pain in the United States. J Pain. 2019 ; 20 (2) : 146–160. DOI: 10.1016/j.jpain.2018.07.006.</mixed-citation><mixed-citation xml:lang="en">Pitcher M. H., Von Korff M., Bushnell M. C., Porter L. Prevalence and Profile of High-Impact Chronic Pain in the United States. J Pain. 2019 ; 20 (2) : 146–160. DOI: 10.1016/j.jpain.2018.07.006.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Macfarlane G. J., Barnish M. S., Jones G. T. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 ; 76 (11) : 1815–1822. DOI: 10.1136/annrheumdis-2017-211476.</mixed-citation><mixed-citation xml:lang="en">Macfarlane G. J., Barnish M. S., Jones G. T. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017 ; 76 (11) : 1815–1822. DOI: 10.1136/annrheumdis-2017-211476.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ensrud K. E., Ewing S. K., Cawthon P. M., et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009 ; 57 (3) : 492–498. DOI: 10.1111/j.1532-5415.2009.02137.x.</mixed-citation><mixed-citation xml:lang="en">Ensrud K. E., Ewing S. K., Cawthon P. M., et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009 ; 57 (3) : 492–498. DOI: 10.1111/j.1532-5415.2009.02137.x.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Felson D. T., Niu J., Yang T., et al. Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI. Osteoarthritis Cartilage. 2013 ; 21 (6) : 789–795. DOI: 10.1016/j.joca.2013.03.001.</mixed-citation><mixed-citation xml:lang="en">Felson D. T., Niu J., Yang T., et al. Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI. Osteoarthritis Cartilage. 2013 ; 21 (6) : 789–795. DOI: 10.1016/j.joca.2013.03.001.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Misra D., Felson D. T., Silliman R. A., et al. Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci. 2015 ; 70 (3) : 339–344. DOI: 10.1093/gerona/glu102.</mixed-citation><mixed-citation xml:lang="en">Misra D., Felson D. T., Silliman R. A., et al. Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci. 2015 ; 70 (3) : 339–344. DOI: 10.1093/gerona/glu102.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">McGuigan F. E., Bartosch P., Åkesson K. E. Musculoskeletal health and frailty. Best Pract Res Clin Rheumatol. 2017 ; 31 (2) : 145–159. DOI: 10.1016/j.berh.2017.11.002.</mixed-citation><mixed-citation xml:lang="en">McGuigan F. E., Bartosch P., Åkesson K. E. Musculoskeletal health and frailty. Best Pract Res Clin Rheumatol. 2017 ; 31 (2) : 145–159. DOI: 10.1016/j.berh.2017.11.002.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura K. A «super-aged» society and the «locomotive syndrome». J Orthop Sci. 2008 ; 13 (1) : 1–2. DOI: 10.1007/s00776-007-1202-6.</mixed-citation><mixed-citation xml:lang="en">Nakamura K. A «super-aged» society and the «locomotive syndrome». J Orthop Sci. 2008 ; 13 (1) : 1–2. DOI: 10.1007/s00776-007-1202-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ogata T., Muranaga S., Ishibashi H., et al. Development of a screening program to assess motor function in the adult population: a cross-sectional observational study. J Orthop Sci. 2015 ; 20 (5) : 888–895. DOI: 10.1007/s00776-015-0737-1.</mixed-citation><mixed-citation xml:lang="en">Ogata T., Muranaga S., Ishibashi H., et al. Development of a screening program to assess motor function in the adult population: a cross-sectional observational study. J Orthop Sci. 2015 ; 20 (5) : 888–895. DOI: 10.1007/s00776-015-0737-1.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshimura N., Oka H., Muraki S., et al. Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. J Orthop Sci. 2011 ; 16 (6) : 768–777. DOI: 10.1007/s00776-011-0160-1.</mixed-citation><mixed-citation xml:lang="en">Yoshimura N., Oka H., Muraki S., et al. Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. J Orthop Sci. 2011 ; 16 (6) : 768–777. DOI: 10.1007/s00776-011-0160-1.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura A., Seichi A., Konno S., et al. Prevalence of locomotive syndrome in Japan: a nationwide, cross-sectional Internet survey. J Orthop Sci. 2014 ; 19 (5) : 792–797. DOI: 10.1007/s00776-014-0606-3.</mixed-citation><mixed-citation xml:lang="en">Kimura A., Seichi A., Konno S., et al. Prevalence of locomotive syndrome in Japan: a nationwide, cross-sectional Internet survey. J Orthop Sci. 2014 ; 19 (5) : 792–797. DOI: 10.1007/s00776-014-0606-3.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshimura N., Muraki S., Nakamura K., Tanaka S. Epidemiology of the locomotive syndrome: The 140 Reviews research on osteoarthritis/osteoporosis against disability study 2005–2015. Mod Rheumatol. 2017 ; 27 (1) : 1–7. DOI: 10.1080/14397595.2016.1226471.</mixed-citation><mixed-citation xml:lang="en">Yoshimura N., Muraki S., Nakamura K., Tanaka S. Epidemiology of the locomotive syndrome: The 140 Reviews research on osteoarthritis/osteoporosis against disability study 2005–2015. Mod Rheumatol. 2017 ; 27 (1) : 1–7. DOI: 10.1080/14397595.2016.1226471.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">The outline of the results of National Livelihood Survey 2014. Ministry of Health, Labour, and Welfare [of Japan. Электрон. дан. (In Japanese.). [Электронный ресурс. Available at: https://www.mhlw.go.jp/toukei/saikin/hw/ktyosa/k-tyosa13/dl/06.pdf.</mixed-citation><mixed-citation xml:lang="en">The outline of the results of National Livelihood Survey 2014. Ministry of Health, Labour, and Welfare [of Japan. Электрон. дан. (In Japanese.). [Электронный ресурс. Available at: https://www.mhlw.go.jp/toukei/saikin/hw/ktyosa/k-tyosa13/dl/06.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang T., Yang T., Zhang W., et al. Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study. Arthritis Res Ther. 2021 ; 23 (1) : 156. DOI: 10.1186/s13075-021-02539-2.</mixed-citation><mixed-citation xml:lang="en">Jiang T., Yang T., Zhang W., et al. Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study. Arthritis Res Ther. 2021 ; 23 (1) : 156. DOI: 10.1186/s13075-021-02539-2.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Thakur M., Dickenson A. H., Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014 ; 10 (6) : 374–380. DOI: 10.1038/nrrheum.2014.47.</mixed-citation><mixed-citation xml:lang="en">Thakur M., Dickenson A. H., Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014 ; 10 (6) : 374–380. DOI: 10.1038/nrrheum.2014.47.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов А. В., Воробьёва Н. М., Ховасова Н. О. и др. Особенности гериатрического статуса у пожилых пациентов с остеоартритом в сочетании с невропатической болью: данные российского эпидемиологического исследования ЭВКАЛИПТ. // Современная ревматология. — 2022. — Т. 16, № 3. — С. 50–59.</mixed-citation><mixed-citation xml:lang="en">Naumov A. V., Vorobyeva N. M., Hovasova N. O., et al. Features of geriatric status in elderly patients with osteoarthritis combined with neuropathic pain: data from the Russian epidemiological study EVKALIPT. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022 ; 16 (3) : 50–59 (In Russ.). DOI: 10.14412/1996-7012-2022-3-50-59.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Xiao Q., Cai B., Yin A., et al. L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study. BMC Med. 2022 ; 20 (1) : 308. DOI: 10.1186/s12916-022-02510-1.</mixed-citation><mixed-citation xml:lang="en">Xiao Q., Cai B., Yin A., et al. L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study. BMC Med. 2022 ; 20 (1) : 308. DOI: 10.1186/s12916-022-02510-1.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Poisbeau P., Aouad M., Gazzo G., et al. Cholecalciferol (Vitamin D3) Reduces Rat Neuropathic Pain by Modulating Opioid Signaling. Mol Neurobiol. 2019 ; 56 (10) : 7208–7221. DOI: 10.1007/s12035-019-1582-6.</mixed-citation><mixed-citation xml:lang="en">Poisbeau P., Aouad M., Gazzo G., et al. Cholecalciferol (Vitamin D3) Reduces Rat Neuropathic Pain by Modulating Opioid Signaling. Mol Neurobiol. 2019 ; 56 (10) : 7208–7221. DOI: 10.1007/s12035-019-1582-6.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Shipton E. A., Shipton E. E. Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities. Pain Res Treat. 2015 ; 2015 : 904967. DOI: 10.1155/2015/904967.</mixed-citation><mixed-citation xml:lang="en">Shipton E. A., Shipton E. E. Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities. Pain Res Treat. 2015 ; 2015 : 904967. DOI: 10.1155/2015/904967.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Zadro J., Shirley D., Ferreira M., et al. Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies. Pain Physician. 2017 ; 20 (7) : 611–640.</mixed-citation><mixed-citation xml:lang="en">Zadro J., Shirley D., Ferreira M., et al. Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies. Pain Physician. 2017 ; 20 (7) : 611–640.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., Malihi Z., Stewart A. W., et al. The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr. 2018 ; 21 (11) : 2022–2037. DOI: 10.1017/S1368980018000551.</mixed-citation><mixed-citation xml:lang="en">Wu Z., Malihi Z., Stewart A. W., et al. The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr. 2018 ; 21 (11) : 2022–2037. DOI: 10.1017/S1368980018000551.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Chew S. T. H., Kayambu G., Lew C. C. H., et al. Singapore multidisciplinary consensus recommendations on muscle health in older adults: assessment and multimodal targeted intervention across the continuum of care. BMC Geriatr. 2021 ; 21 (1) : 314. DOI: 10.1186/s12877-021-02240-8.</mixed-citation><mixed-citation xml:lang="en">Chew S. T. H., Kayambu G., Lew C. C. H., et al. Singapore multidisciplinary consensus recommendations on muscle health in older adults: assessment and multimodal targeted intervention across the continuum of care. BMC Geriatr. 2021 ; 21 (1) : 314. DOI: 10.1186/s12877-021-02240-8.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Shipton E. E., Shipton E. A. Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States. Pain Ther. 2015 ; 4 (1) : 67–87. DOI: 10.1007/s40122-015-0036-8.</mixed-citation><mixed-citation xml:lang="en">Shipton E. E., Shipton E. A. Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States. Pain Ther. 2015 ; 4 (1) : 67–87. DOI: 10.1007/s40122-015-0036-8.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Mohamed Y., Haifa H., Datel O., et al. Intérêt des marqueurs du remodelage osseux dans le diagnostic de l'ostéoporose et la prediction du risqué de fracture [The role of biochemical markers of bone turnover in the diagnosis of osteoporosis and predicting fracture risk (in French). Tunis Med. 2014 ; 92 (5) : 304–310.</mixed-citation><mixed-citation xml:lang="en">Mohamed Y., Haifa H., Datel O., et al. Intérêt des marqueurs du remodelage osseux dans le diagnostic de l'ostéoporose et la prediction du risqué de fracture [The role of biochemical markers of bone turnover in the diagnosis of osteoporosis and predicting fracture risk (in French). Tunis Med. 2014 ; 92 (5) : 304–310.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Hadjistavropoulos T., Herr K., Turk D. C., et al. An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin J Pain. 2007 ; 23 (1 Suppl) : S1–43. DOI: 10.1097/AJP.0b013e31802be869.</mixed-citation><mixed-citation xml:lang="en">Hadjistavropoulos T., Herr K., Turk D. C., et al. An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin J Pain. 2007 ; 23 (1 Suppl) : S1–43. DOI: 10.1097/AJP.0b013e31802be869.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Abdulla A., Adams N., Bone M., et al. Guidance on the management of pain in older people. Age Ageing. 2013 ; 42 Suppl 1 : i1–57. DOI: 10.1093/ageing/afs200.</mixed-citation><mixed-citation xml:lang="en">Abdulla A., Adams N., Bone M., et al. Guidance on the management of pain in older people. Age Ageing. 2013 ; 42 Suppl 1 : i1–57. DOI: 10.1093/ageing/afs200.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons . J Am Geriatr Soc. 2009 ; 57 (8) : 1331–1346. DOI: 10.1111/j.1532-5415.2009.02376.x.</mixed-citation><mixed-citation xml:lang="en">American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons . J Am Geriatr Soc. 2009 ; 57 (8) : 1331–1346. DOI: 10.1111/j.1532-5415.2009.02376.x.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Ali S., Garcia J. M. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options — a mini-review. Gerontology. 2014 ; 60 (4) : 294–305. DOI: 10.1159/000356760.</mixed-citation><mixed-citation xml:lang="en">Ali S., Garcia J. M. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options — a mini-review. Gerontology. 2014 ; 60 (4) : 294–305. DOI: 10.1159/000356760.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Gillespie L. D., Robertson M. C., Gillespie W. J., et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2009 ; (2) : CD007146. DOI: 10.1002/14651858.CD007146.pub2.</mixed-citation><mixed-citation xml:lang="en">Gillespie L. D., Robertson M. C., Gillespie W. J., et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2009 ; (2) : CD007146. DOI: 10.1002/14651858.CD007146.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Turner S., Arthur G., Lyons R. A., et al. Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev. 2011 ; 2011 (2) : CD003600. DOI: 10.1002/14651858.CD003600.pub3.</mixed-citation><mixed-citation xml:lang="en">Turner S., Arthur G., Lyons R. A., et al. Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev. 2011 ; 2011 (2) : CD003600. DOI: 10.1002/14651858.CD003600.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Cumming R. G., Thomas M., Szonyi G., et al. Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention. J Am Geriatr Soc. 1999 ; 47 (12) : 1397–1402. DOI: 10.1111/j.1532-5415.1999.tb01556.x .</mixed-citation><mixed-citation xml:lang="en">Cumming R. G., Thomas M., Szonyi G., et al. Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention. J Am Geriatr Soc. 1999 ; 47 (12) : 1397–1402. DOI: 10.1111/j.1532-5415.1999.tb01556.x .</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Calvani R., Miccheli A., Landi F., et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging. 2013 ; 2 (1) : 38–53.</mixed-citation><mixed-citation xml:lang="en">Calvani R., Miccheli A., Landi F., et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging. 2013 ; 2 (1) : 38–53.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Symons T. B., Sheffield-Moore M., Wolfe R. R., Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc. 2009 ; 109 (9) : 1582–1586. DOI: 10.1016/j.jada.2009.06.369.</mixed-citation><mixed-citation xml:lang="en">Symons T. B., Sheffield-Moore M., Wolfe R. R., Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc. 2009 ; 109 (9) : 1582–1586. DOI: 10.1016/j.jada.2009.06.369.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Kim C. O., Lee K. R. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: a community-based randomized controlled study. J Gerontol A Biol Sci Med Sci. 2013 ; 68 (3) : 309–316. DOI: 10.1093/gerona/gls167.</mixed-citation><mixed-citation xml:lang="en">Kim C. O., Lee K. R. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: a community-based randomized controlled study. J Gerontol A Biol Sci Med Sci. 2013 ; 68 (3) : 309–316. DOI: 10.1093/gerona/gls167.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">You T., Ogawa E. F., Thapa S., et al. Effects of Tai Chi on beta endorphin and inflammatory markers in older adults with chronic pain: an exploratory study. Aging Clin Exp Res. 2020 ; 32 (7) : 1389–1392. DOI: 10.1007/s40520-019-01316-1.</mixed-citation><mixed-citation xml:lang="en">You T., Ogawa E. F., Thapa S., et al. Effects of Tai Chi on beta endorphin and inflammatory markers in older adults with chronic pain: an exploratory study. Aging Clin Exp Res. 2020 ; 32 (7) : 1389–1392. DOI: 10.1007/s40520-019-01316-1.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">You T., Ogawa E. F., Thapa S., et al. Tai Chi for older adults with chronic multisite pain: a randomized controlled pilot study. Aging Clin Exp Res. 2018 ; 30 (11) : 1335–1343. DOI: 10.1007/s40520-018-0922-0.</mixed-citation><mixed-citation xml:lang="en">You T., Ogawa E. F., Thapa S., et al. Tai Chi for older adults with chronic multisite pain: a randomized controlled pilot study. Aging Clin Exp Res. 2018 ; 30 (11) : 1335–1343. DOI: 10.1007/s40520-018-0922-0.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Li F., Harmer P., Fitzgerald K., et al. Effectiveness of a Therapeutic Tai Ji Quan Intervention vs a Multimodal Exercise Intervention to Prevent Falls Among Older Adults at High Risk of Falling: A Randomized Clinical Trial. JAMA Intern Med. 2018 ; 178 (10) : 1301–1310. DOI: 10.1001/jamainternmed.2018.3915.</mixed-citation><mixed-citation xml:lang="en">Li F., Harmer P., Fitzgerald K., et al. Effectiveness of a Therapeutic Tai Ji Quan Intervention vs a Multimodal Exercise Intervention to Prevent Falls Among Older Adults at High Risk of Falling: A Randomized Clinical Trial. JAMA Intern Med. 2018 ; 178 (10) : 1301–1310. DOI: 10.1001/jamainternmed.2018.3915.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Gatica-Rojas V., Cartes-Velásquez R., AlbornozVerdugo M. E., et al. Effects of a Nintendo Wii exercise program versus Tai Chi Chuan on standing balance in older adults: a preliminary study. J Phys Ther Sci. 2019 ; 31 (1) : 1–4. DOI: 10.1589/jpts.31.1.</mixed-citation><mixed-citation xml:lang="en">Gatica-Rojas V., Cartes-Velásquez R., AlbornozVerdugo M. E., et al. Effects of a Nintendo Wii exercise program versus Tai Chi Chuan on standing balance in older adults: a preliminary study. J Phys Ther Sci. 2019 ; 31 (1) : 1–4. DOI: 10.1589/jpts.31.1.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Qi M., Moyle W., Jones C., Weeks B. Tai Chi Combined With Resistance Training for Adults Aged 50 Years and Older: A Systematic Review. J Geriatr Phys Ther. 2020 ; 43 (1) : 32–41. DOI: 10.1519/JPT.0000000000000218.</mixed-citation><mixed-citation xml:lang="en">Qi M., Moyle W., Jones C., Weeks B. Tai Chi Combined With Resistance Training for Adults Aged 50 Years and Older: A Systematic Review. J Geriatr Phys Ther. 2020 ; 43 (1) : 32–41. DOI: 10.1519/JPT.0000000000000218.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Bannuru R. R., Osani M. C., Vaysbrot E. E., et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 ; 27 (11) : 1578–1589. DOI: 10.1016/j.joca.2019.06.011.</mixed-citation><mixed-citation xml:lang="en">Bannuru R. R., Osani M. C., Vaysbrot E. E., et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019 ; 27 (11) : 1578–1589. DOI: 10.1016/j.joca.2019.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Ali A., Arif A. W., Bhan C., et al. Managing Chronic Pain in the Elderly: An Overview of the Recent Therapeutic Advancements. Cureus. 2018 ; 10 (9) : e3293. DOI: 10.7759/cureus.3293.</mixed-citation><mixed-citation xml:lang="en">Ali A., Arif A. W., Bhan C., et al. Managing Chronic Pain in the Elderly: An Overview of the Recent Therapeutic Advancements. Cureus. 2018 ; 10 (9) : e3293. DOI: 10.7759/cureus.3293.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Knopp-Sihota J. A., MacGregor T., Reeves J. T. H., et al. Management of Chronic Pain in Long-Term Care: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2022 ; 23 (9) : 1507–1516.e0. DOI: 10.1016/j.jamda.2022.04.008.</mixed-citation><mixed-citation xml:lang="en">Knopp-Sihota J. A., MacGregor T., Reeves J. T. H., et al. Management of Chronic Pain in Long-Term Care: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2022 ; 23 (9) : 1507–1516.e0. DOI: 10.1016/j.jamda.2022.04.008.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Coxib and traditional NSAID Trialists' (CNT) Collaboration et al. Vascular and upper gastrointestinal effects of non-steroidal antiinflammatory drugs: metaanalyses of individual participant data from randomised trials. Lancet. 2013 ; 382 (9894) : 769–779. DOI: 10.1016/S0140-6736(13)60900-9.</mixed-citation><mixed-citation xml:lang="en">Coxib and traditional NSAID Trialists' (CNT) Collaboration et al. Vascular and upper gastrointestinal effects of non-steroidal antiinflammatory drugs: metaanalyses of individual participant data from randomised trials. Lancet. 2013 ; 382 (9894) : 769–779. DOI: 10.1016/S0140-6736(13)60900-9.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuda K., Miyamae F., Tomita K., et al. Association between chronic kidney disease and synergistic, potentially nephrotoxic medication use in elderly hospitalized patients: A single-center cross-sectional study. Int J Clin Pharmacol Ther. 2019 ; 57 (7) : 353–361. DOI: 10.5414/CP203429.</mixed-citation><mixed-citation xml:lang="en">Fukuda K., Miyamae F., Tomita K., et al. Association between chronic kidney disease and synergistic, potentially nephrotoxic medication use in elderly hospitalized patients: A single-center cross-sectional study. Int J Clin Pharmacol Ther. 2019 ; 57 (7) : 353–361. DOI: 10.5414/CP203429.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Schjerning Olsen A. M., Gislason G. H., McGettigan P., et al. Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction. JAMA. 2015 ; 313 (8) : 805–814. DOI: 10.1001/jama.2015.0809.</mixed-citation><mixed-citation xml:lang="en">Schjerning Olsen A. M., Gislason G. H., McGettigan P., et al. Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction. JAMA. 2015 ; 313 (8) : 805–814. DOI: 10.1001/jama.2015.0809.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Lo-Ciganic W. H., Floden L., Lee J. K., et al. Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2017 ; 25 (9) : 1390–1398. DOI: 10.1016/j.joca.2017.03.017.</mixed-citation><mixed-citation xml:lang="en">Lo-Ciganic W. H., Floden L., Lee J. K., et al. Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2017 ; 25 (9) : 1390–1398. DOI: 10.1016/j.joca.2017.03.017.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Dong Y. H., Chang C. H., Wu L. C., et al. Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. Br J Clin Pharmacol. 2018 ; 84 (5) : 1045–1056. DOI: 10.1111/bcp.13537.</mixed-citation><mixed-citation xml:lang="en">Dong Y. H., Chang C. H., Wu L. C., et al. Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. Br J Clin Pharmacol. 2018 ; 84 (5) : 1045–1056. DOI: 10.1111/bcp.13537.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan J. Q., Tsoi K. K., Yang M. Systematic review with network meta-analysis: comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity. Aliment Pharmacol Ther. 2016 ; 43 (2) : 1262–1275. DOI: 10.1111/apt.13642.</mixed-citation><mixed-citation xml:lang="en">Yuan J. Q., Tsoi K. K., Yang M. Systematic review with network meta-analysis: comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity. Aliment Pharmacol Ther. 2016 ; 43 (2) : 1262–1275. DOI: 10.1111/apt.13642.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Derry S., Wiffen P. J., Moore R. A., Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014 ; 2014 (7) : CD010958. DOI: 10.1002/14651858.CD010958.pub2.</mixed-citation><mixed-citation xml:lang="en">Derry S., Wiffen P. J., Moore R. A., Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014 ; 2014 (7) : CD010958. DOI: 10.1002/14651858.CD010958.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Pickering G., Martin E., Tiberghien F., et al. Localized neuropathic pain: an expert consensus on local treatments. Drug Des Devel Ther. 2017 ; 11 : 2709–2718. DOI: 10.2147/DDDT.S142630.</mixed-citation><mixed-citation xml:lang="en">Pickering G., Martin E., Tiberghien F., et al. Localized neuropathic pain: an expert consensus on local treatments. Drug Des Devel Ther. 2017 ; 11 : 2709–2718. DOI: 10.2147/DDDT.S142630.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">de León-Casasola O. A., Mayoral V. The topical 5 % lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence. J Pain Res. 2016 ; 9 : 67–79. DOI: 10.2147/JPR.S99231.</mixed-citation><mixed-citation xml:lang="en">de León-Casasola O. A., Mayoral V. The topical 5 % lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence. J Pain Res. 2016 ; 9 : 67–79. DOI: 10.2147/JPR.S99231.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Moore R. A., Straube S., Wiffen P. J., et al. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009 ; (3) : CD007076. DOI: 10.1002/14651858.CD007076.pub2.</mixed-citation><mixed-citation xml:lang="en">Moore R. A., Straube S., Wiffen P. J., et al. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009 ; (3) : CD007076. DOI: 10.1002/14651858.CD007076.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Reisner L. Pharmacological management of persistent pain in older persons. J Pain. 2011 ; 12 (3 Suppl 1) : S21–29. DOI: 10.1016/j.jpain.2011.01.001.</mixed-citation><mixed-citation xml:lang="en">Reisner L. Pharmacological management of persistent pain in older persons. J Pain. 2011 ; 12 (3 Suppl 1) : S21–29. DOI: 10.1016/j.jpain.2011.01.001.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Snedecor S. J., Sudharshan L., Cappelleri J. C., et al. Systematic review and meta-analysis of pharmacological therapies for pain associated with postherpetic neuralgia and less common neuropathic conditions. Int J Clin Pract. 2014 ; 68 : 900–918. DOI: 10.1111/ijcp.12411.</mixed-citation><mixed-citation xml:lang="en">Snedecor S. J., Sudharshan L., Cappelleri J. C., et al. Systematic review and meta-analysis of pharmacological therapies for pain associated with postherpetic neuralgia and less common neuropathic conditions. Int J Clin Pract. 2014 ; 68 : 900–918. DOI: 10.1111/ijcp.12411.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Oneschuk D., al-Shahri M. Z. The pattern of gabapentin use in a tertiary palliative care unit. J Palliat Care. 2003 ; 19 : 185–187.</mixed-citation><mixed-citation xml:lang="en">Oneschuk D., al-Shahri M. Z. The pattern of gabapentin use in a tertiary palliative care unit. J Palliat Care. 2003 ; 19 : 185–187.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Wiffen P. J., Derry S., Bell R. F., et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 ; 6 (6) : CD007938. DOI: 10.1002/14651858.CD007938.pub4.</mixed-citation><mixed-citation xml:lang="en">Wiffen P. J., Derry S., Bell R. F., et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 ; 6 (6) : CD007938. DOI: 10.1002/14651858.CD007938.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Baos Sю., Lui M., Walker-Smith T., et al. Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study). Anesthesiology. 2025 ; 143 (4) : 851–861. DOI: 10.1097/ALN.0000000000005655.</mixed-citation><mixed-citation xml:lang="en">Baos Sю., Lui M., Walker-Smith T., et al. Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study). Anesthesiology. 2025 ; 143 (4) : 851–861. DOI: 10.1097/ALN.0000000000005655.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein D. J., Lu Y., Detke M. J., et al. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005 ; 116 (1–2) : 109–118. DOI: 10.1016/j.pain.2005.03.029</mixed-citation><mixed-citation xml:lang="en">Goldstein D. J., Lu Y., Detke M. J., et al. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005 ; 116 (1–2) : 109–118. DOI: 10.1016/j.pain.2005.03.029</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Sindrup S. H., Otto M., Finnerup N. B., Jensen T. S. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 ; 96 (6) : 399–409. DOI: 10.1111/j.1742-7843.2005.pto_96696601.x.</mixed-citation><mixed-citation xml:lang="en">Sindrup S. H., Otto M., Finnerup N. B., Jensen T. S. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 ; 96 (6) : 399–409. DOI: 10.1111/j.1742-7843.2005.pto_96696601.x.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Finnerup N. B., Attal N., Haroutounian S., et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 ; 14 (2) : 162–173. DOI: 10.1016/S1474-4422(14)70251-0.</mixed-citation><mixed-citation xml:lang="en">Finnerup N. B., Attal N., Haroutounian S., et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 ; 14 (2) : 162–173. DOI: 10.1016/S1474-4422(14)70251-0.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Mu A., Weinberg E., Moulin D. E., Clarke H. Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement. Can Fam Physician. 2017 ; 63 (11) : 844–852.</mixed-citation><mixed-citation xml:lang="en">Mu A., Weinberg E., Moulin D. E., Clarke H. Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement. Can Fam Physician. 2017 ; 63 (11) : 844–852.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Dworkin R.H., O’Connor A.B., Audette J., et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010 ; 85 (3) : S3–14. DOI: 10.4065/mcp.2009.0649.</mixed-citation><mixed-citation xml:lang="en">Dworkin R.H., O’Connor A.B., Audette J., et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010 ; 85 (3) : S3–14. DOI: 10.4065/mcp.2009.0649.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Saab K., Gada U., Culakova E., et al. Personalized outcomes in neuropathic pain: a clinical relevance and assay sensitivity analysis from a randomized controlled trial. Pain Med. 2025 ; 26 (1) : 22–29. DOI: 10.1093/pm/pnae095.</mixed-citation><mixed-citation xml:lang="en">Saab K., Gada U., Culakova E., et al. Personalized outcomes in neuropathic pain: a clinical relevance and assay sensitivity analysis from a randomized controlled trial. Pain Med. 2025 ; 26 (1) : 22–29. DOI: 10.1093/pm/pnae095.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Tarride J. E., Collet J. P., Choiniere M., et al. The economic burden of neuropathic pain in Canada. J Med Econ. 2006 ; 9 (1–4) : 55–68. DOI: 10.3111/200609055068.</mixed-citation><mixed-citation xml:lang="en">Tarride J. E., Collet J. P., Choiniere M., et al. The economic burden of neuropathic pain in Canada. J Med Econ. 2006 ; 9 (1–4) : 55–68. DOI: 10.3111/200609055068.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Cipriani A., Koesters M., Furukawa T. A., et al. Duloxetine versus other anti-depressive agents for depression. Cochrane Database Syst Rev. 2012 ; 10 (10) : CD006533. DOI: 10.1002/14651858.CD006533.pub2.</mixed-citation><mixed-citation xml:lang="en">Cipriani A., Koesters M., Furukawa T. A., et al. Duloxetine versus other anti-depressive agents for depression. Cochrane Database Syst Rev. 2012 ; 10 (10) : CD006533. DOI: 10.1002/14651858.CD006533.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Everitt H., Baldwin D. S., Stuart B., et al. Antidepressants for insomnia in adults. Cochrane Database Syst Rev. 2018 ; 5 (5) : CD010753. DOI: 10.1002/14651858.CD010753.pub2.</mixed-citation><mixed-citation xml:lang="en">Everitt H., Baldwin D. S., Stuart B., et al. Antidepressants for insomnia in adults. Cochrane Database Syst Rev. 2018 ; 5 (5) : CD010753. DOI: 10.1002/14651858.CD010753.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">O’Malley P. G., Balden E., Tomkins G., et al. Treatment of fibromyalgia with antidepressants: a metaanalysis. J Gen Intern Med. 2000 ; 15 (9) : 659–666. DOI: 10.1046/j.1525-1497.2000.06279.x.</mixed-citation><mixed-citation xml:lang="en">O’Malley P. G., Balden E., Tomkins G., et al. Treatment of fibromyalgia with antidepressants: a metaanalysis. J Gen Intern Med. 2000 ; 15 (9) : 659–666. DOI: 10.1046/j.1525-1497.2000.06279.x.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Thorpe J., Shum B., Moore R. A., et al. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 ; 2 (2) : CD010585. DOI: 10.1002/14651858.CD010585.pub2.</mixed-citation><mixed-citation xml:lang="en">Thorpe J., Shum B., Moore R. A., et al. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 ; 2 (2) : CD010585. DOI: 10.1002/14651858.CD010585.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Turner B. J., Liang Y. Drug Overdose in a Retrospective Cohort with Non-Cancer Pain Treated with Opioids, Antidepressants, and/or Sedative-Hypnotics: Interactions with Mental Health Disorders. J Gen Intern Med. 2015 ; 30 (8) : 1081–1096. DOI: 10.1007/s11606-015-3199-4.</mixed-citation><mixed-citation xml:lang="en">Turner B. J., Liang Y. Drug Overdose in a Retrospective Cohort with Non-Cancer Pain Treated with Opioids, Antidepressants, and/or Sedative-Hypnotics: Interactions with Mental Health Disorders. J Gen Intern Med. 2015 ; 30 (8) : 1081–1096. DOI: 10.1007/s11606-015-3199-4.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Gallagher R. M. Management of neuropathic pain: translating mechanistic advances and evidence-based research into clinical practice. Clin J Pain. 2006 ; 22 (1 Suppl) : S2–8. DOI: 10.1097/01.ajp.0000193827.07453.d6.</mixed-citation><mixed-citation xml:lang="en">Gallagher R. M. Management of neuropathic pain: translating mechanistic advances and evidence-based research into clinical practice. Clin J Pain. 2006 ; 22 (1 Suppl) : S2–8. DOI: 10.1097/01.ajp.0000193827.07453.d6.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Blazer D., Hybels C., Simonsick E., Hanlon J. T. Sedative, hypnotic, and antianxiety medication use in an aging cohort over ten years: a racial comparison. J Am Geriatr Soc. 2000 ; 48 (9) : 1073–1079. DOI: 10.1111/j.1532-5415.2000.tb04782.x.</mixed-citation><mixed-citation xml:lang="en">Blazer D., Hybels C., Simonsick E., Hanlon J. T. Sedative, hypnotic, and antianxiety medication use in an aging cohort over ten years: a racial comparison. J Am Geriatr Soc. 2000 ; 48 (9) : 1073–1079. DOI: 10.1111/j.1532-5415.2000.tb04782.x.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2015 ; 63 (11) : 2227–2246. DOI: 10.1111/jgs.13702.</mixed-citation><mixed-citation xml:lang="en">By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2015 ; 63 (11) : 2227–2246. DOI: 10.1111/jgs.13702.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Furlan A. D., Sandoval J. A., Mailis-Gagnon A., Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ. 2006 ; 174 (11) : 1589–1594. DOI: 10.1503/cmaj.051528.</mixed-citation><mixed-citation xml:lang="en">Furlan A. D., Sandoval J. A., Mailis-Gagnon A., Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ. 2006 ; 174 (11) : 1589–1594. DOI: 10.1503/cmaj.051528.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Nuesch E., Rutjes A. W., Husni E., et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009 ; (4) : CD003115. DOI: 10.1002/14651858.CD003115.pub3.</mixed-citation><mixed-citation xml:lang="en">Nuesch E., Rutjes A. W., Husni E., et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009 ; (4) : CD003115. DOI: 10.1002/14651858.CD003115.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Inacio M. C. S., Cashman K., Pratt N. L., et al. Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients. Osteoarthritis Cartilage. 2018 ; 26 (3) : 356–362. DOI: 10.1016/j.joca.2017.11.016.</mixed-citation><mixed-citation xml:lang="en">Inacio M. C. S., Cashman K., Pratt N. L., et al. Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients. Osteoarthritis Cartilage. 2018 ; 26 (3) : 356–362. DOI: 10.1016/j.joca.2017.11.016.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Birke H., Kurita G.P., Sjøgren P., et al. Chronic noncancer pain and the epidemic prescription of opioids in the Danish population: trends from 2000 to 2013. Acta Anaesthesiol Scand. 2016 ; 60 (5) : 623–633. DOI: 10.1111/aas.12700.</mixed-citation><mixed-citation xml:lang="en">Birke H., Kurita G.P., Sjøgren P., et al. Chronic noncancer pain and the epidemic prescription of opioids in the Danish population: trends from 2000 to 2013. Acta Anaesthesiol Scand. 2016 ; 60 (5) : 623–633. DOI: 10.1111/aas.12700.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Volkow N. D., McLellan A. T. Opioid abuse in chronic pain — misconceptions and mitigation strategies. N Engl J Med. 2016 ; 374 (13) : 1253–1263. DOI: 10.1056/NEJMra1507771.</mixed-citation><mixed-citation xml:lang="en">Volkow N. D., McLellan A. T. Opioid abuse in chronic pain — misconceptions and mitigation strategies. N Engl J Med. 2016 ; 374 (13) : 1253–1263. DOI: 10.1056/NEJMra1507771.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Rizzoli R., Boonen S, Brandi M. L., et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013 ; 29 (4) : 305–313. DOI: 10.1185/03007995.2013.766162.</mixed-citation><mixed-citation xml:lang="en">Rizzoli R., Boonen S, Brandi M. L., et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013 ; 29 (4) : 305–313. DOI: 10.1185/03007995.2013.766162.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., Malihi Z., Stewart A. W., et al. Effect of Vitamin D Supplementation on Pain: A Systematic Review and Metaanalysis. Pain Physician. 2016 ; 19 (7) : 415–427.</mixed-citation><mixed-citation xml:lang="en">Wu Z., Malihi Z., Stewart A. W., et al. Effect of Vitamin D Supplementation on Pain: A Systematic Review and Metaanalysis. Pain Physician. 2016 ; 19 (7) : 415–427.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Mukherjee D., Lahiry S., Thakur S., Chakraborty D. S. Effect of 1,25 dihydroxy vitamin D3 supplementation on pain 142 Reviews relief in early rheumatoid arthritis. J Family Med Prim Care. 2019 ; 8 (2) : 517–522. DOI: 10.4103/jfmpc.jfmpc_446_18.</mixed-citation><mixed-citation xml:lang="en">Mukherjee D., Lahiry S., Thakur S., Chakraborty D. S. Effect of 1,25 dihydroxy vitamin D3 supplementation on pain 142 Reviews relief in early rheumatoid arthritis. J Family Med Prim Care. 2019 ; 8 (2) : 517–522. DOI: 10.4103/jfmpc.jfmpc_446_18.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng O. T., Souzdalnitski D., Vrooman B., Cheng J. Evidence-based knee injections for the management of arthritis. Pain Med. 2012 ; 13 (6) : 740–753. DOI: 10.1111/j.1526-4637.2012.01394.x.</mixed-citation><mixed-citation xml:lang="en">Cheng O. T., Souzdalnitski D., Vrooman B., Cheng J. Evidence-based knee injections for the management of arthritis. Pain Med. 2012 ; 13 (6) : 740–753. DOI: 10.1111/j.1526-4637.2012.01394.x.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Charlesworth J., Fitzpatrick J., Perera N. K. P., Orchard J. Osteoarthritis — a systematic review of long-term safety implications for osteoarthritis of the knee. BMC Musculoskelet Disord. 2019 ; 20 (1) : 151. DOI: 10.1186/s12891-019-2525-0.</mixed-citation><mixed-citation xml:lang="en">Charlesworth J., Fitzpatrick J., Perera N. K. P., Orchard J. Osteoarthritis — a systematic review of long-term safety implications for osteoarthritis of the knee. BMC Musculoskelet Disord. 2019 ; 20 (1) : 151. DOI: 10.1186/s12891-019-2525-0.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Plaas A., Li J., Riesco J., et al. Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. Arthritis Res Ther. 2011 ; 13 (2) : R46. DOI: 10.1186/ar3286.</mixed-citation><mixed-citation xml:lang="en">Plaas A., Li J., Riesco J., et al. Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis. Arthritis Res Ther. 2011 ; 13 (2) : R46. DOI: 10.1186/ar3286.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Honvo G., Reginster J. Y., Rannou F., et al. Safety of Intra-articular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019 ; 36 (Suppl 1) : 101–127. DOI: 10.1007/s40266-019-00657-w.</mixed-citation><mixed-citation xml:lang="en">Honvo G., Reginster J. Y., Rannou F., et al. Safety of Intra-articular Hyaluronic Acid Injections in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019 ; 36 (Suppl 1) : 101–127. DOI: 10.1007/s40266-019-00657-w.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Trigkilidas D., Anand A. The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain. Ann R Coll Surg Engl. 2013 ; 95 (8) : 545–551. DOI: 10.1308/rcsann.2013.95.8.545.</mixed-citation><mixed-citation xml:lang="en">Trigkilidas D., Anand A. The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain. Ann R Coll Surg Engl. 2013 ; 95 (8) : 545–551. DOI: 10.1308/rcsann.2013.95.8.545.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Iannitti T., Lodi D., Palmieri B. Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid. Drugs R D. 2011 ; 11 (1) : 13–27. DOI: 10.2165/11539760-000000000-00000.</mixed-citation><mixed-citation xml:lang="en">Iannitti T., Lodi D., Palmieri B. Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid. Drugs R D. 2011 ; 11 (1) : 13–27. DOI: 10.2165/11539760-000000000-00000.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Bowman S., Awad M. E., Hamrick M. W., et al. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018 ; 7 (1) : 6. DOI: 10.1186/s40169-017-0180-3.</mixed-citation><mixed-citation xml:lang="en">Bowman S., Awad M. E., Hamrick M. W., et al. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018 ; 7 (1) : 6. DOI: 10.1186/s40169-017-0180-3.</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Rewald S., Mesters I., Lenssen A. F., et al. Effect of aquacycling on pain and physical functioning compared with usual care in patients with knee osteoarthritis: study protocol of a randomised controlled trial. BMC Musculoskelet Disord. 2016 ; 17 : 88. DOI: 10.1186/s12891-016-0939-5.</mixed-citation><mixed-citation xml:lang="en">Rewald S., Mesters I., Lenssen A. F., et al. Effect of aquacycling on pain and physical functioning compared with usual care in patients with knee osteoarthritis: study protocol of a randomised controlled trial. BMC Musculoskelet Disord. 2016 ; 17 : 88. DOI: 10.1186/s12891-016-0939-5.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Beaudart C., Lengelé L., Leclercq V., et al. Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon. Drugs. 2020 ; 80 (18) : 1947–1959. DOI: 10.1007/s40265-020-01423-8.</mixed-citation><mixed-citation xml:lang="en">Beaudart C., Lengelé L., Leclercq V., et al. Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon. Drugs. 2020 ; 80 (18) : 1947–1959. DOI: 10.1007/s40265-020-01423-8.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Yang W., Sun C., He S. Q. et al. The Efficacy and Safety of Disease-Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis-a Systematic Review and Network Meta-Analysis. J Gen Intern Med. 2021 ; 36 (7) : 2085–2093. DOI: 10.1007/s11606-021-06755-z.</mixed-citation><mixed-citation xml:lang="en">Yang W., Sun C., He S. Q. et al. The Efficacy and Safety of Disease-Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis-a Systematic Review and Network Meta-Analysis. J Gen Intern Med. 2021 ; 36 (7) : 2085–2093. DOI: 10.1007/s11606-021-06755-z.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Pelletier J. P., Raynauld J. P., Dorais M., et al. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis. Rheumatology (Oxford). 2020 ; 59 (12) : 3858–3868. DOI: 10.1093/rheumatology/keaa072.</mixed-citation><mixed-citation xml:lang="en">Pelletier J. P., Raynauld J. P., Dorais M., et al. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis. Rheumatology (Oxford). 2020 ; 59 (12) : 3858–3868. DOI: 10.1093/rheumatology/keaa072.</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">Liu X., Machado G. C., Eyles J. P., et al. Dietary supplements for treating osteoarthritis: a systematic review and metaanalysis. Br J Sports Med. 2018 ; 52 (3) : 167–175. DOI: 10.1136/bjsports-2016-097333.</mixed-citation><mixed-citation xml:lang="en">Liu X., Machado G. C., Eyles J. P., et al. Dietary supplements for treating osteoarthritis: a systematic review and metaanalysis. Br J Sports Med. 2018 ; 52 (3) : 167–175. DOI: 10.1136/bjsports-2016-097333.</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">Kongtharvonskul J., Anothaisintawee T., McEvoy M., et al. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network metaanalysis. Eur J Med Res. 2015 ; 20 (1) : 24. DOI: 10.1186/s40001-015-0115-7.</mixed-citation><mixed-citation xml:lang="en">Kongtharvonskul J., Anothaisintawee T., McEvoy M., et al. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network metaanalysis. Eur J Med Res. 2015 ; 20 (1) : 24. DOI: 10.1186/s40001-015-0115-7.</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">Christensen R., Bartels E. M., Astrup A., Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008 ; 16 (4) : 399–408. DOI: 10.1016/j.joca.2007.10.003.</mixed-citation><mixed-citation xml:lang="en">Christensen R., Bartels E. M., Astrup A., Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008 ; 16 (4) : 399–408. DOI: 10.1016/j.joca.2007.10.003.</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">Maheu E., Cadet C., Marty M., et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 2014 ; 73 (2) : 376–384. DOI: 10.1136/annrheumdis-2012-202485.</mixed-citation><mixed-citation xml:lang="en">Maheu E., Cadet C., Marty M., et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 2014 ; 73 (2) : 376–384. DOI: 10.1136/annrheumdis-2012-202485.</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">Dixon A. S, Kersley G. D., Mercer R., et al. A doubleblind controlled trial of Rumalon in the treatment of painful osteoarthrosis of the hip. Ann Rheum Dis. 1970 ; 29 (2) : 193–194. DOI: 10.1136/ard.29.2.193-b.</mixed-citation><mixed-citation xml:lang="en">Dixon A. S, Kersley G. D., Mercer R., et al. A doubleblind controlled trial of Rumalon in the treatment of painful osteoarthrosis of the hip. Ann Rheum Dis. 1970 ; 29 (2) : 193–194. DOI: 10.1136/ard.29.2.193-b.</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">Rejholec V., Králová M. Langzeitbehandlung der Coxarthrose mit Rumalon®. Akt Rheumatol. 1984 ; 9 (S 2) : 139–148. DOI: 10.1055/s-2008-1048133.</mixed-citation><mixed-citation xml:lang="en">Rejholec V., Králová M. Langzeitbehandlung der Coxarthrose mit Rumalon®. Akt Rheumatol. 1984 ; 9 (S 2) : 139–148. DOI: 10.1055/s-2008-1048133.</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">Gramajo R. J., Cutroneo E. J., Fernandez D. E., et al. A single-blind, placebo-controlled study of glycosaminoglycanpeptide complex ('Rumalon') in patients with osteoarthritis of the hip or knee. Curr Med Res Opin. 1989 ; 11 (6) : 366–373. DOI: 10.1185/03007998909110137.</mixed-citation><mixed-citation xml:lang="en">Gramajo R. J., Cutroneo E. J., Fernandez D. E., et al. A single-blind, placebo-controlled study of glycosaminoglycanpeptide complex ('Rumalon') in patients with osteoarthritis of the hip or knee. Curr Med Res Opin. 1989 ; 11 (6) : 366–373. DOI: 10.1185/03007998909110137.</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">Rejholec V. Clinical trials of anti-osteoarthritic agents. Scand J Rheumatol Suppl. 1990 ; 81 : 28–31. DOI: 10.3109/03009749009096943.</mixed-citation><mixed-citation xml:lang="en">Rejholec V. Clinical trials of anti-osteoarthritic agents. Scand J Rheumatol Suppl. 1990 ; 81 : 28–31. DOI: 10.3109/03009749009096943.</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Карякин А. Н., Смирнов А. В., Беневоленская Л. И. Применение Румалона при гонартрозе. // Терапевтический архив. — 1997. — Т. 69, № 5. — С. 64–66.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Karyakin A. N., Smirnov A. V., Benevolenskaya L. I. Primenenie Rumalona pri gonartroze. Terapevticheskii arkhiv. 1997 ; 69 (5) : 64–66 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">Pavelká K, Gatterová J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage. 2000 ; 8 (5) : 335–342. DOI: 10.1053/joca.1999.0307.</mixed-citation><mixed-citation xml:lang="en">Pavelká K, Gatterová J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage. 2000 ; 8 (5) : 335–342. DOI: 10.1053/joca.1999.0307.</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Шарапова Е. П., Таскина Е. А. и др. Многоцентровое слепое рандомизированное плацебоконтролируемое исследование симптом- и структурно-модифицирующего действия препарата алфлутоп у больных остеоартрозом коленных суставов. Сообщение 2 — оценка структурно-модифицирующего действия препарата // Научно-практическая ревматология– 2014. — Т. 52, № 2. — С. 174–177.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Sharapova E. P., Taskina E. A., et al. A multicenter, blind, randomized, placebo-controlled study of the symptom- and structure-modifying effet of alflutop in patients with knee osteoarthritis. Report 2: the assessment of the structure-modifying effect of the drug. Rheumatology Science and Practice. 2014 ; 52 (2) : 174–177 (In Russ.). DOI: 10.14412/1995-4484-2014-174-177.</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Таскина Е. А., Лила А. М. и др. Многоцентровое проспективное рандомизированное исследование эффективности и безопасности препарата Алфлутоп® в альтернирующем режиме по сравнению со стандартным режимом. Сообщение 1: оценка эффективности препарата при различных схемах применения. // Современная ревматология. — 2019. — Т. 13, № 3. — С. 51–59.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Taskina E. A., Lila A. M., et al. A multicenter, prospective, randomized trial of the efficacy and safety of Alflutop® in an alternating dosing regimen versus the standard one. Communication 1: Evaluation of the efficacy of the drug in different treatment regimens. Sovremennaya Revmatologiya = Modern Rheumatology Journal 2019 ; 13 (3) : 51–59 (In Russ.). DOI: 10.14412/1996-7012-2019-3-51-59.</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">Бердюгин К. А., Кадынцев И. В., Бердюгина О. В. и др. Оценка эффективности и безопасности комбинированной терапии симптоматическим препаратом замедленного действия и гиалуроновой кислотой в сравнении с монотерапией гиалуроновой кислотой у пациентов с остеоартритом коленного сустава // Современная ревматология. — 2021. — Т. 14, № 3. — С. 63–70.</mixed-citation><mixed-citation xml:lang="en">Berdyugin K. A., Kadyncev I. V., Berdyugina O. V., et al. Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with knee osteoarthritis. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2020 ; 14 (3) : 63–70 (In Russ.). DOI: 10.14412/1996-7012-2020-3-63-70.</mixed-citation></citation-alternatives></ref><ref id="cit138"><label>138</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyère O., Honvo G., Veronese N., et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 ; 49 (3) : 337–350. DOI: 10.1016/j.semarthrit.2019.04.008.</mixed-citation><mixed-citation xml:lang="en">Bruyère O., Honvo G., Veronese N., et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 ; 49 (3) : 337–350. DOI: 10.1016/j.semarthrit.2019.04.008.</mixed-citation></citation-alternatives></ref><ref id="cit139"><label>139</label><citation-alternatives><mixed-citation xml:lang="ru">Navarro S. L., Levy L., Curtis K. R., et al. Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans. Microorganisms. 2019 ; 7 (12) : 610. DOI: 10.3390/microorganisms7120610.</mixed-citation><mixed-citation xml:lang="en">Navarro S. L., Levy L., Curtis K. R., et al. Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans. Microorganisms. 2019 ; 7 (12) : 610. DOI: 10.3390/microorganisms7120610.</mixed-citation></citation-alternatives></ref><ref id="cit140"><label>140</label><citation-alternatives><mixed-citation xml:lang="ru">Hu S., Wang J., Xu Y., et al. Anti-inflammation effects of fucosylated chondroitin sulphate from Acaudina molpadioides by altering gut microbiota in obese mice. Food Funct. 2019 ; 10 (3) : 1736–1746. DOI: 10.1039/c8fo02364f.</mixed-citation><mixed-citation xml:lang="en">Hu S., Wang J., Xu Y., et al. Anti-inflammation effects of fucosylated chondroitin sulphate from Acaudina molpadioides by altering gut microbiota in obese mice. Food Funct. 2019 ; 10 (3) : 1736–1746. DOI: 10.1039/c8fo02364f.</mixed-citation></citation-alternatives></ref><ref id="cit141"><label>141</label><citation-alternatives><mixed-citation xml:lang="ru">Shmagel A., Demmer R., Knights D., et al. The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition: A Systematic Review of Evidence from Animal and Human Studies. Nutrients. 2019 ; 11 (2) : 294. DOI: 10.3390/nu11020294.</mixed-citation><mixed-citation xml:lang="en">Shmagel A., Demmer R., Knights D., et al. The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition: A Systematic Review of Evidence from Animal and Human Studies. Nutrients. 2019 ; 11 (2) : 294. DOI: 10.3390/nu11020294.</mixed-citation></citation-alternatives></ref><ref id="cit142"><label>142</label><citation-alternatives><mixed-citation xml:lang="ru">Левин О. С., Олюнин Д. Ю., Голубева Л. В. Эффективность алфлутопа при хронической вертеброгенной люмбоишиалгии по данным двойного слепого плацебоконтролируемого исследования. // Научно-практическая ревматология. — 2004. — Т. 42, № 4. — С. 80–84.</mixed-citation><mixed-citation xml:lang="en">Levin O. S., Olyunin D. Yu., Golubeva L. V. Alflutop efficacy in chronic vertebrogenous lumbar ischialgia. A double blind placebo controlled study. Rheumatology Science and Practice. 2004 ; 42 (4) : 80–84 (In Russ.). DOI: 14412/1995-4484-2004-809.</mixed-citation></citation-alternatives></ref><ref id="cit143"><label>143</label><citation-alternatives><mixed-citation xml:lang="ru">Nosivets D., Opryshko V. I. Systemic review of international studies on the use of Alflutop in the comprehensive pharmacotherapy of back pain. International Neurological Journal. 2019 ; 95 (1) : 64–69.</mixed-citation><mixed-citation xml:lang="en">Nosivets D., Opryshko V. I. Systemic review of international studies on the use of Alflutop in the comprehensive pharmacotherapy of back pain. International Neurological Journal. 2019 ; 95 (1) : 64–69.</mixed-citation></citation-alternatives></ref><ref id="cit144"><label>144</label><citation-alternatives><mixed-citation xml:lang="ru">Живолупов С. А., Данилов А. Б., Баранцевич Е. Р. и др. Эффективность и безопасность применения препарата Алфлутоп при лечении болевого синдрома в нижней части спины // Manage Pain. — 2020. — № 1. — С. 41–48.</mixed-citation><mixed-citation xml:lang="en">Zhivolupov S. A., Danilov A. B., Barancevich E. R., et al. Efficacy and safety of the use of the drug Alflutop in the treatment of pain in the lower back. Manage Pain. 2020 ; 1 : 41–48 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit145"><label>145</label><citation-alternatives><mixed-citation xml:lang="ru">Каратеев А. Е. Биоактивный концентрат мелкой морской рыбы: оценка эффективности и безопасности препарата на основании анализа 37 клинических исследований. // Современная ревматология. — 2020. — Т. 14, № 4. — С. 111–124.</mixed-citation><mixed-citation xml:lang="en">Karateev A.E. Bioactive concentrate from small sea fish: evaluation of the efficacy and safety of the drug on the basis of the analysis of 37 clinical trials. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2020 ; 14 (4) : 111–124 (In Russ.). DOI: 10.14412/1996-7012-2020-4-111-124.</mixed-citation></citation-alternatives></ref><ref id="cit146"><label>146</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Бельская Г. Н., Каракулова Ю. В. и др. Возможности патогенетического лечения хронической боли в спине. // Manage Pain. — 2018. — № 2. — С. 47–51.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Bel’skaya G. N., Karakulova Yu. V., et al. Vozmozhnosti patogeneticheskogo lecheniya hronicheskoi boli v spine. Manage Pain. 2018 ; 2 : 47–51. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit147"><label>147</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Шарапова Е. П., Кашеварова Н. Г., и др. Применение АРТРА МСМ Форте у пациентов с остеоартрозом коленного сустава: результаты рандомизированного открытого сравнительного изучения эффективности и переносимости препарата. // Терапевтический архив. — 2015. — Т. 87, № 12. — C. 49–54.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Sharapova E. P., Kashevarova N. G., et al. Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug // Terapevticheskii arkhiv. 2015 ; 87 (12) : 49–54 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit148"><label>148</label><citation-alternatives><mixed-citation xml:lang="ru">Jüni P., Reichenbach S., Dieppe P. Osteoarthritis: rational approach to treating the individual. Best Pract Res Clin Rheumatol. 2006 ; 20 (4) : 721–740. DOI: 10.1016/j.berh.2006.05.002.</mixed-citation><mixed-citation xml:lang="en">Jüni P., Reichenbach S., Dieppe P. Osteoarthritis: rational approach to treating the individual. Best Pract Res Clin Rheumatol. 2006 ; 20 (4) : 721–740. DOI: 10.1016/j.berh.2006.05.002.</mixed-citation></citation-alternatives></ref><ref id="cit149"><label>149</label><citation-alternatives><mixed-citation xml:lang="ru">Barbieri A., Vanhaecht K., Van Herck P., et al. Effects of clinical pathways in the joint replacement: a meta-analysis. BMC Med. 2009 ; 7 : 32. DOI: 10.1186/1741-7015-7-32.</mixed-citation><mixed-citation xml:lang="en">Barbieri A., Vanhaecht K., Van Herck P., et al. Effects of clinical pathways in the joint replacement: a meta-analysis. BMC Med. 2009 ; 7 : 32. DOI: 10.1186/1741-7015-7-32.</mixed-citation></citation-alternatives></ref><ref id="cit150"><label>150</label><citation-alternatives><mixed-citation xml:lang="ru">Gooch K., Marshall D. A., Faris P. D., et al. Comparative effectiveness of alternative clinical pathways for primary hip and knee joint replacement patients: a pragmatic randomized, controlled trial. Osteoarthritis Cartilage. 2012 ; 20 (10) : 1086–1094. DOI: 10.1016/j.joca.2012.06.017.</mixed-citation><mixed-citation xml:lang="en">Gooch K., Marshall D. A., Faris P. D., et al. Comparative effectiveness of alternative clinical pathways for primary hip and knee joint replacement patients: a pragmatic randomized, controlled trial. Osteoarthritis Cartilage. 2012 ; 20 (10) : 1086–1094. DOI: 10.1016/j.joca.2012.06.017.</mixed-citation></citation-alternatives></ref><ref id="cit151"><label>151</label><citation-alternatives><mixed-citation xml:lang="ru">Van Herck P., Vanhaecht K., Deneckere S., et al. Key interventions and outcomes in joint arthroplasty clinical pathways: a systematic review. J Eval Clin Pract. 2010 ; 16 (1) : 39–49. DOI: 10.1111/j.1365-2753.2008.01111.x.</mixed-citation><mixed-citation xml:lang="en">Van Herck P., Vanhaecht K., Deneckere S., et al. Key interventions and outcomes in joint arthroplasty clinical pathways: a systematic review. J Eval Clin Pract. 2010 ; 16 (1) : 39–49. DOI: 10.1111/j.1365-2753.2008.01111.x.</mixed-citation></citation-alternatives></ref><ref id="cit152"><label>152</label><citation-alternatives><mixed-citation xml:lang="ru">Schmucker A. M., Hupert N., Mandl L. A. The Impact of Frailty on Short-Term Outcomes After Elective Hip and Knee Arthroplasty in Older Adults: A Systematic Review. Geriatr Orthop Surg Rehabil. 2019 ; 10 : 2151459319835109. DOI: 10.1177/2151459319835109.</mixed-citation><mixed-citation xml:lang="en">Schmucker A. M., Hupert N., Mandl L. A. The Impact of Frailty on Short-Term Outcomes After Elective Hip and Knee Arthroplasty in Older Adults: A Systematic Review. Geriatr Orthop Surg Rehabil. 2019 ; 10 : 2151459319835109. DOI: 10.1177/2151459319835109.</mixed-citation></citation-alternatives></ref><ref id="cit153"><label>153</label><citation-alternatives><mixed-citation xml:lang="ru">Madara K. C., Marmon A., Aljehani M., et al. Progressive rehabilitation after total hip arthroplasty: a pilot and feasibility study. Int J Sports Phys Ther. 2019 ; 14 (4) : 564–581.</mixed-citation><mixed-citation xml:lang="en">Madara K. C., Marmon A., Aljehani M., et al. Progressive rehabilitation after total hip arthroplasty: a pilot and feasibility study. Int J Sports Phys Ther. 2019 ; 14 (4) : 564–581.</mixed-citation></citation-alternatives></ref><ref id="cit154"><label>154</label><citation-alternatives><mixed-citation xml:lang="ru">Heiberg K. E., Ekeland A., Mengshoel A. M. Functional improvements desired by patients before and in the first year after total hip arthroplasty. BMC Musculoskelet Disord. 2013 ; 14 : 243. DOI: 10.1186/1471-2474-14-243.</mixed-citation><mixed-citation xml:lang="en">Heiberg K. E., Ekeland A., Mengshoel A. M. Functional improvements desired by patients before and in the first year after total hip arthroplasty. BMC Musculoskelet Disord. 2013 ; 14 : 243. DOI: 10.1186/1471-2474-14-243.</mixed-citation></citation-alternatives></ref><ref id="cit155"><label>155</label><citation-alternatives><mixed-citation xml:lang="ru">Di Monaco M., Castiglioni C. Which type of exercise therapy is effective after hip arthroplasty? A systematic review of Randomized Controlled Trials. Eur J Phys Rehabil Med. 2013 ; 49 (6) : 893–907.</mixed-citation><mixed-citation xml:lang="en">Di Monaco M., Castiglioni C. Which type of exercise therapy is effective after hip arthroplasty? A systematic review of Randomized Controlled Trials. Eur J Phys Rehabil Med. 2013 ; 49 (6) : 893–907.</mixed-citation></citation-alternatives></ref><ref id="cit156"><label>156</label><citation-alternatives><mixed-citation xml:lang="ru">Judd D. L., Dennis D. A., Thomas A. C., et al. Muscle strength and functional recovery during the first year after THA. Clin Orthop Relat Res. 2014 ; 472 (2) : 654–664. DOI: 10.1007/s11999-013-3136-y.</mixed-citation><mixed-citation xml:lang="en">Judd D. L., Dennis D. A., Thomas A. C., et al. Muscle strength and functional recovery during the first year after THA. Clin Orthop Relat Res. 2014 ; 472 (2) : 654–664. DOI: 10.1007/s11999-013-3136-y.</mixed-citation></citation-alternatives></ref><ref id="cit157"><label>157</label><citation-alternatives><mixed-citation xml:lang="ru">Swanson E. A., Schmalzried T. P., Dorey F. J. Activity recommendations after total hip and knee arthroplasty a survey of the American Association for Hip and Knee Surgeons. J Arthroplasty. 2009 ; 24 (6 Suppl) : 120–126. DOI: 10.1016/j.arth.2009.05.014.</mixed-citation><mixed-citation xml:lang="en">Swanson E. A., Schmalzried T. P., Dorey F. J. Activity recommendations after total hip and knee arthroplasty a survey of the American Association for Hip and Knee Surgeons. J Arthroplasty. 2009 ; 24 (6 Suppl) : 120–126. DOI: 10.1016/j.arth.2009.05.014.</mixed-citation></citation-alternatives></ref><ref id="cit158"><label>158</label><citation-alternatives><mixed-citation xml:lang="ru">Petterson S. C., Mizner R. L., Stevens J. E., et al. Improved function from progressive strengthening interventions after total knee arthroplasty: A randomized clinical trial with an imbedded prospective cohort. Arthritis Care Res. 2009 ; 61 (2) : 174–183. DOI: 10.1002/art.24167.</mixed-citation><mixed-citation xml:lang="en">Petterson S. C., Mizner R. L., Stevens J. E., et al. Improved function from progressive strengthening interventions after total knee arthroplasty: A randomized clinical trial with an imbedded prospective cohort. Arthritis Care Res. 2009 ; 61 (2) : 174–183. DOI: 10.1002/art.24167.</mixed-citation></citation-alternatives></ref><ref id="cit159"><label>159</label><citation-alternatives><mixed-citation xml:lang="ru">Dilekçi E., Özkuk K., Kaki B. Effect of balneotherapy on pain and fatigue in elderly with knee osteoarthritis receiving physical therapy: a randomized trial. Int J Biometeorol. 2019 ; 63 (12) : 1555–1568. DOI: 10.1007/s00484-019-01768-0.</mixed-citation><mixed-citation xml:lang="en">Dilekçi E., Özkuk K., Kaki B. Effect of balneotherapy on pain and fatigue in elderly with knee osteoarthritis receiving physical therapy: a randomized trial. Int J Biometeorol. 2019 ; 63 (12) : 1555–1568. DOI: 10.1007/s00484-019-01768-0.</mixed-citation></citation-alternatives></ref><ref id="cit160"><label>160</label><citation-alternatives><mixed-citation xml:lang="ru">Hahm S. C., Shin H. J., Lee M. G., et al. Mud Therapy Combined with Core Exercise for Chronic Nonspecific Low Back Pain: A Pilot, Single-Blind, Randomized Controlled Trial. Evid Based Complement Alternat Med. 2020 ; 2020 : 7547452. DOI: 10.1155/2020/7547452.</mixed-citation><mixed-citation xml:lang="en">Hahm S. C., Shin H. J., Lee M. G., et al. Mud Therapy Combined with Core Exercise for Chronic Nonspecific Low Back Pain: A Pilot, Single-Blind, Randomized Controlled Trial. Evid Based Complement Alternat Med. 2020 ; 2020 : 7547452. DOI: 10.1155/2020/7547452.</mixed-citation></citation-alternatives></ref><ref id="cit161"><label>161</label><citation-alternatives><mixed-citation xml:lang="ru">Bruyère O., Honvo G., Veronese N., et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 ; 49 (3) : 337–350. DOI: 10.1016/j.semarthrit.2019.04.008.</mixed-citation><mixed-citation xml:lang="en">Bruyère O., Honvo G., Veronese N., et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 ; 49 (3) : 337–350. DOI: 10.1016/j.semarthrit.2019.04.008.</mixed-citation></citation-alternatives></ref><ref id="cit162"><label>162</label><citation-alternatives><mixed-citation xml:lang="ru">Fuggle N., Laslop A., Rizzoli R., et al. Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs. 2025 ; 85 (3 ): 343–360. DOI: 10.1007/s40265-024-02138-w.</mixed-citation><mixed-citation xml:lang="en">Fuggle N., Laslop A., Rizzoli R., et al. Treatment of Osteoporosis and Osteoarthritis in the Oldest Old. Drugs. 2025 ; 85 (3 ): 343–360. DOI: 10.1007/s40265-024-02138-w.</mixed-citation></citation-alternatives></ref><ref id="cit163"><label>163</label><citation-alternatives><mixed-citation xml:lang="ru">Palma Dos Reis R., Giacovelli G., Girolami F., et al. Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials. Open Rheumatol J. 2011 ; 5 : 69–77. DOI: 10.2174/1874312901105010069.</mixed-citation><mixed-citation xml:lang="en">Palma Dos Reis R., Giacovelli G., Girolami F., et al. Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials. Open Rheumatol J. 2011 ; 5 : 69–77. DOI: 10.2174/1874312901105010069.</mixed-citation></citation-alternatives></ref><ref id="cit164"><label>164</label><citation-alternatives><mixed-citation xml:lang="ru">Honvo G., Reginster J. Y., Rabenda V., et al. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019 ; 36 (Suppl 1) : 65–99. DOI: 10.1007/s40266-019-00662-z.</mixed-citation><mixed-citation xml:lang="en">Honvo G., Reginster J. Y., Rabenda V., et al. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019 ; 36 (Suppl 1) : 65–99. DOI: 10.1007/s40266-019-00662-z.</mixed-citation></citation-alternatives></ref><ref id="cit165"><label>165</label><citation-alternatives><mixed-citation xml:lang="ru">Таскина Е. А., Алексеева Л. И., Кашеварова Н. Г., Лила А. М. Длительное многоцентровое наблюдательное исследование препарата Алфлутоп в России: применение у пациентов с остеоартритом коленных суставов (сообщение 4) // Современная ревматология. — 2024. — Т 18, № 4. — С. 80–88.</mixed-citation><mixed-citation xml:lang="en">Taskina E. A., Alekseeva L. I., Kashevarova N. G., Lila A. M. Long-term multicenter observational study of the drug Alflutop in Russia: use in patients with knee osteoarthritis (report 4). Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2024 ; 18 (4) : 80–88 (In Russ.). DOI: 10.14412/1996-7012-2024-4-80-88.</mixed-citation></citation-alternatives></ref><ref id="cit166"><label>166</label><citation-alternatives><mixed-citation xml:lang="ru">Prabhoo R., Billa G. Undenatured collagen type II for the treatment of osteoarthritis: a review. Int. J. Res. Orthop. 2018 ; 4 (5) : 684–689. DOI: 10.18203/issn.2455-4510. IntJResOrthop20183386.</mixed-citation><mixed-citation xml:lang="en">Prabhoo R., Billa G. Undenatured collagen type II for the treatment of osteoarthritis: a review. Int. J. Res. Orthop. 2018 ; 4 (5) : 684–689. DOI: 10.18203/issn.2455-4510. IntJResOrthop20183386.</mixed-citation></citation-alternatives></ref><ref id="cit167"><label>167</label><citation-alternatives><mixed-citation xml:lang="ru">Pabst O., Mowat A. M. Oral tolerance to food protein. Mucosal Immunol. 2012 ; 5 (3) : 232–239. DOI: 10.1038/mi.2012.4.</mixed-citation><mixed-citation xml:lang="en">Pabst O., Mowat A. M. Oral tolerance to food protein. Mucosal Immunol. 2012 ; 5 (3) : 232–239. DOI: 10.1038/mi.2012.4.</mixed-citation></citation-alternatives></ref><ref id="cit168"><label>168</label><citation-alternatives><mixed-citation xml:lang="ru">Jaensson E., Uronen-Hansson H., Pabst O., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008 ; 205 (9) : 2139–2149. DOI: 10.1084/jem.20080414.</mixed-citation><mixed-citation xml:lang="en">Jaensson E., Uronen-Hansson H., Pabst O., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008 ; 205 (9) : 2139–2149. DOI: 10.1084/jem.20080414.</mixed-citation></citation-alternatives></ref><ref id="cit169"><label>169</label><citation-alternatives><mixed-citation xml:lang="ru">Iwata M., Hirakiyama A., Eshima Y., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004 ; 21 (4) : 527–538. DOI: 10.1016/j.immuni.2004.08.011.</mixed-citation><mixed-citation xml:lang="en">Iwata M., Hirakiyama A., Eshima Y., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004 ; 21 (4) : 527–538. DOI: 10.1016/j.immuni.2004.08.011.</mixed-citation></citation-alternatives></ref><ref id="cit170"><label>170</label><citation-alternatives><mixed-citation xml:lang="ru">Weiner H. L., da Cunha A. P., Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011 ; 241 (1) : 241–259. DOI: 10.1111/j.1600-065X.2011.01017.x.</mixed-citation><mixed-citation xml:lang="en">Weiner H. L., da Cunha A. P., Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011 ; 241 (1) : 241–259. DOI: 10.1111/j.1600-065X.2011.01017.x.</mixed-citation></citation-alternatives></ref><ref id="cit171"><label>171</label><citation-alternatives><mixed-citation xml:lang="ru">Kim K. S., Hong S. W., Han D., et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016 ; 351 (6275) : 858–863. DOI: 10.1126/science.aac5560.</mixed-citation><mixed-citation xml:lang="en">Kim K. S., Hong S. W., Han D., et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016 ; 351 (6275) : 858–863. DOI: 10.1126/science.aac5560.</mixed-citation></citation-alternatives></ref><ref id="cit172"><label>172</label><citation-alternatives><mixed-citation xml:lang="ru">Kim K. S., Surh C. D. Induction of Immune Tolerance to Dietary Antigens. Adv Exp Med Biol. 2015 ; 850 : 93–118. DOI: 10.1007/978-3-319-15774-0_8.</mixed-citation><mixed-citation xml:lang="en">Kim K. S., Surh C. D. Induction of Immune Tolerance to Dietary Antigens. Adv Exp Med Biol. 2015 ; 850 : 93–118. DOI: 10.1007/978-3-319-15774-0_8.</mixed-citation></citation-alternatives></ref><ref id="cit173"><label>173</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar P., Bansal P., Rajnish R. K., et al. Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited meta-analysis. Am J Transl Res. 2023 ; 15 (9) : 5545–5555.</mixed-citation><mixed-citation xml:lang="en">Kumar P., Bansal P., Rajnish R. K., et al. Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited meta-analysis. Am J Transl Res. 2023 ; 15 (9) : 5545–5555.</mixed-citation></citation-alternatives></ref><ref id="cit174"><label>174</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л. И., Кашеварова Н. Г., Таскина Е. А. и др. Опыт применения неденатурированного коллагена II типа у пациентов с остеоартритом коленных суставов III стадии: многоцентровое проспективное двойное слепое плацебо-контролируемое рандомизированное исследование (часть II) // Терапевтический архив. — 2025. — Т. 97, № 1. — C. 54–64.</mixed-citation><mixed-citation xml:lang="en">Alekseeva L. I., Kashevarova N. G., Taskina E. A., et al. Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial. Terapevticheskii arkhiv. 2025 ; 97 (1) : 54–64 (In Russ.). DOI: 10.26442/00403660.2025.01.203145.</mixed-citation></citation-alternatives></ref><ref id="cit175"><label>175</label><citation-alternatives><mixed-citation xml:lang="ru">Мазуров В. И., Беляева И. Б., Трофимов Е. А. и др. Сравнение эффективности комбинации неденатурированного коллагена II типа, босвеллиевых кислот, метилсульфонилметана, витаминов С и D3 и комбинации хондроитина сульфата и глюкозамина гидрохлорида в терапии первичного остеоартрита коленного сустава // Терапевтический архив. — 2023. — Т. 95, № 12. — C. 1141–1150.</mixed-citation><mixed-citation xml:lang="en">Mazurov V. I. B., Trofimov E. A., et al. Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D3 and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee join. Terapevticheskii arkhiv. 2023 ; 95 (12) : 1141–1150 (In Russ.). DOI: 10.26442/00403660.2023.12.202540.</mixed-citation></citation-alternatives></ref><ref id="cit176"><label>176</label><citation-alternatives><mixed-citation xml:lang="ru">Наумов А. В., Ховасова Н. О., Унковский А. В. Эффективность комбинированного препарата хондроитина сульфата и глюкозамина гидрохлорида в лечении остеоартрита: систематический обзор исследований // Терапевтический архив. — 2024. — Т. 96, № 12. — С. 1223–1229.</mixed-citation><mixed-citation xml:lang="en">Naumov A. V., Khovasova N. O., Unkovskiy A. V. Efficacy of combination chondroitin sulfate plus glucosamine hydrochloride in osteoarthritis: A systematic review. Terapevticheskii arkhiv. 2024 ; 96 (12) : 1223–1229 (In Russ.). DOI: 10.26442/00403660.2024.12.203039.</mixed-citation></citation-alternatives></ref><ref id="cit177"><label>177</label><citation-alternatives><mixed-citation xml:lang="ru">Katona G. A clinical trial of glycosaminoglycanpeptide complex ('Rumalon') in patients with osteoarthritis of the knee. Curr Med Res Opin. 1987 ; 10 (9) : 625–633. DOI: 10.1185/03007998709112416.</mixed-citation><mixed-citation xml:lang="en">Katona G. A clinical trial of glycosaminoglycanpeptide complex ('Rumalon') in patients with osteoarthritis of the knee. Curr Med Res Opin. 1987 ; 10 (9) : 625–633. DOI: 10.1185/03007998709112416.</mixed-citation></citation-alternatives></ref><ref id="cit178"><label>178</label><citation-alternatives><mixed-citation xml:lang="ru">Sun C. M., Hall J. A., Blank R. B., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007 ; 204 (8) : 1775–1785. DOI: 10.1084/jem.20070602.</mixed-citation><mixed-citation xml:lang="en">Sun C. M., Hall J. A., Blank R. B., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007 ; 204 (8) : 1775–1785. DOI: 10.1084/jem.20070602.</mixed-citation></citation-alternatives></ref><ref id="cit179"><label>179</label><citation-alternatives><mixed-citation xml:lang="ru">Мазуров В. И., Алексеева Л. И., Беляева И. Б. и др. Эффективность, безопасность и перспективы применения комбинации нативного коллагена II типа, метилсульфонилметана, босвеллиевых кислот, витаминов С и D3 при остеоартрите коленных суставов: резолюция Совета экспертов // Терапевтический архив. — 2024. — Т. 96, № 1. — С. 68–74.</mixed-citation><mixed-citation xml:lang="en">Mazurov V. I., Alekseeva L. I., Belyaeva I. B., et al. Efficacy, safety and prospects of using a combination of native type II collagen, methylsulfonylmethane, boswellic acids, vitamin C and vitamin D3 in knee osteoarthritis: a resolution of the Expert panel. Terapevticheskii arkhiv. 2024 ; 96 (1) : 68–74 (In Russ.). DOI: 10.26442/00403660.2024.01.202590.</mixed-citation></citation-alternatives></ref><ref id="cit180"><label>180</label><citation-alternatives><mixed-citation xml:lang="ru">Chen C. S., Wen L., Yang F., et al. Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis. J Integr Med. 2025 ; 23 (4) : 357–369. DOI: 10.1016/j.joim.2025.04.008.</mixed-citation><mixed-citation xml:lang="en">Chen C. S., Wen L., Yang F., et al. Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis. J Integr Med. 2025 ; 23 (4) : 357–369. DOI: 10.1016/j.joim.2025.04.008.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
