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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-2-2026-164-174</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-738</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Применение метабиотиков в клинической гериатрической практике (Методические рекомендации Российской ассоциации геронтологов и гериатров)</article-title><trans-title-group xml:lang="en"><trans-title>The use of metabiotics in clinical geriatric practice (Guidelines of the Russian Association of Gerontologists and Geriatricians)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5720-2663</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Машарова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Masharova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, врач-гастроэнтеролог, старший научный сотрудник лаборатории общей гериатрии</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">masharova_aa@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5869-0233</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арефьева</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Arefeva</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арефьева Мария Сергеевна, м.н.с. лаборатории общей гериатрии, гериатр, врач функциональной диагностики</p><p>Москва</p></bio><bio xml:lang="en"><p>Arefeva Mariia Sergeevna</p><p>Moscow</p></bio><email xlink:type="simple">arefieva_ms@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">rgnkc@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр»<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University (Pirogov Medical University), Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>25</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>2</issue><fpage>164</fpage><lpage>174</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Машарова А.А., Арефьева М.С., Ткачева О.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Машарова А.А., Арефьева М.С., Ткачева О.Н.</copyright-holder><copyright-holder xml:lang="en">Masharova A.A., Arefeva M.S., Tkacheva O.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/738">https://www.geriatr-news.com/jour/article/view/738</self-uri><abstract><p>В методических рекомендациях рассматриваются сложные взаимоотношения между кишечной микробиотой и процессами старения, анализируется потенциал терапевтических подходов, направленных на коррекцию микробиома с применением метабиотиков, как перспективного подхода для увеличения продолжительности и качества жизни у лиц гериатрического профиля, представлены преимущества применения метабиотиков в комплексной терапии некоторых заболеваний у лиц пожилого и старческого возраста.</p></abstract><trans-abstract xml:lang="en"><p>These guidelines examine the complex relationships between the gut microbiota and the aging process. They analyze the potential of therapeutic approaches aimed at microbiome correction through the use of metabiotics, presenting this as a promising strategy to increase both the lifespan and healthspan in geriatric populations. The advantages of incorporating metabiotics into the comprehensive therapy of certain diseases in elderly and senile patients are detailed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метабиотики</kwd><kwd>микробиота</kwd><kwd>гериатрия</kwd><kwd>методические рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metabiotics</kwd><kwd>microbiota</kwd><kwd>geriatrics</kwd><kwd>guidelines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hou Y., Dan X., Babbar M., et al. Ageing as a risk factor for neurodegenerative disease. Nat. Rev. Neurol. 2019 ; 15 (10) : 565–581. 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