geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-2-2026-148-156geriatr-642Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESАссоциации уровня ИФР-1 с маркерами статуса питания и воспаления у долгожителейAssociation between IGF-1 levels and markers of nutritional status and inflammation in long-livershttps://orcid.org/0000-0002-2028-3939МачехинаЛ. В.MachekhinaL. V.

Мачехина Любовь Викторовна, заведующая лабораторией биомаркреов старения

Москва

Machekhina Lyubov Viktorovna

Moscow

mlv66@list.ruhttps://orcid.org/0000-0003-0394-4245ШеллиЕ. М.ShelleyE. M.

Москва

Moscow

eva.maria.shelley@gmail.comhttps://orcid.org/0000-0002-6025-7663МамчурА. А.MamchurA. A.

Москва

Moscow

amamchur@cspfmba.ruhttps://orcid.org/0000-0001-8977-4384КаштановаД. А.KashtanovaD. A.

Москва

Moscow

dkashtanova@cspfmba.ruhttps://orcid.org/0009-0006-4830-8057РумянцеваА. М.RumyantsevaA. M.

Москва

Moscow

rumyantseva@cspfmba.ruhttps://orcid.org/0000-0002-9199-6258ЮдинВ. С.YudinV. S.

Москва

Moscow

VYudin@cspfmba.ruhttps://orcid.org/0000-0001-9495-0266МакаровВ. В.MakarovV. V.

Москва

Moscow

Makarov@cspfmba.ruhttps://orcid.org/0000-0001-7378-983XКесикиновА. А.KeskinovA. A.

Москва

Moscow

Keskinov@cspfmba.ruhttps://orcid.org/0000-0003-1775-9235КраевойС. А.KraevoyS. A.

Москва

Moscow

SKraevoy@cspfmba.ruhttps://orcid.org/0000-0002-7942-8004ЮдинС. М.YudinS. M.

Москва

Moscow

yudin@cspmz.ruhttps://orcid.org/0000-0002-3657-0676СтражескоИ. Д.StrazheskoI. D.

Москва

Moscow

strazhesko_id@rgnkc.ruФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр»РоссияPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation (Pirogov University), Russian Gerontology Research and Clinical CenterRussian FederationФГБУ «ЦСП» ФМБА РоссииРоссияCenter for Strategic Planning and Management of Medical and Biological Health Risks, Federal Medical and Biological AgencyRussian Federation20262504202602148156Copyright © Мачехина Л.В., Шелли Е.М., Мамчур А.А., Каштанова Д.А., Румянцева А.М., Юдин В.С., Макаров В.В., Кесикинов А.А., Краевой С.А., Юдин С.М., Стражеско И.Д., 20262026Мачехина Л.В., Шелли Е.М., Мамчур А.А., Каштанова Д.А., Румянцева А.М., Юдин В.С., Макаров В.В., Кесикинов А.А., Краевой С.А., Юдин С.М., Стражеско И.Д.Machekhina L.V., Shelley E.M., Mamchur A.A., Kashtanova D.A., Rumyantseva A.M., Yudin V.S., Makarov V.V., Keskinov A.A., Kraevoy S.A., Yudin S.M., Strazhesko I.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/642

АКТУАЛЬНОСТЬ. Статус питания играет ключевую роль в определении функционального состояния пожилых людей. По данным мировой медицинской литературы, инсулиноподобный фактор роста 1 (ИФР-1) является достоверным маркером статуса питания. Однако измерение уровня ИФР-1 пока не вошло в рутинную клиническую практику, а исследований, посвященных его взаимосвязи с другими маркерами статуса питания у долгожителей, недостаточно. Изучение этих связей особенно важно для углубленного понимания метаболических процессов, влияющих на здоровье и функциональный статус в старшем возрасте.ЦЕЛЬ ИССЛЕДОВАНИЯ. Изучить связь уровня ИФР-1 с маркерами статуса питания и воспаления у долгожителей.МАТЕРИАЛЫ И МЕТОДЫ. Проведено одномоментное исследование с включением 1 450 человек в возрасте 90 лет и старше (долгожителей). Работа одобрена локальным этическим комитетом (протокол от 24.12.2019 № 30). Статистический анализ данных проводился с помощью языка программирования R версии 4.4.0. РЕЗУЛЬТАТЫ. Медиана возраста долгожителей составила 92 года, медиана уровня ИФР-1 — 101 нг/мл. По результатам регрессионного анализа установлено, что увеличение ИФР-1 сопровождается ростом концентрации гемоглобина, общего белка, альбумина, креатинина, общего холестерина, витамина D и лептина. Также наблюдается снижение уровня ферритина, С-реактивного белка (СРБ) и скорости клубочковой фильтрации (СКФ).ВЫВОДЫ. Полученные результаты показывают, что ИФР-1 связан с ключевыми параметрами белкового и липидного обмена, метаболизма железа и воспаления. Наиболее выраженной оказалась обратная связь ИФР-1 с уровнем ферритина, что может свидетельствовать о его роли в регуляции обмена железа. При этом большинство выявленных ассоциаций, хотя и статистически значимы, не имеют ярко выраженного клинического эффекта. Выявленные связи требуют более детального изучения в лонгитудинальных исследованиях.

BACKGROUND. Nutritional status plays a key role in determining the functional state of older adults. According to global literature, insulin-like growth factor 1 (IGF-1) is a reliable biomarker of nutritional status. However, IGF-1 measurement has not yet been integrated into routine clinical practice, and studies investigating its associations with other nutritional markers in long-lived individuals remain limited. Understanding these relationships is particularly important for gaining deeper insights into the metabolic processes influencing health and functional status in advanced age.OBJECTIVE: to assess the association between IGF-1 levels and markers of nutritional status and inflammation in long-livers.MATERIALS AND METHODS. It was a cross-sectional study on the cohort of long-livers. The search for participants was carried out with the involvement of social services, nursing homes, geriatric centers, and other geriatric services. The study was reviewed by the ethics committee (№ 30 24.12.2019). The statistical analysis was performed using R version 4.4.0.RESULTS. The study included 1 450 individuals aged 90 to 104 years who met the inclusion criteria. The median age of the participants was 92 years, and the median IGF-1 level was 101 ng/mL. Regression analysis revealed that higher IGF-1 levels were associated with increased concentrations of hemoglobin, total protein, albumin, creatinine, total cholesterol, vitamin D, and leptin. Conversely, IGF-1 levels were negatively associated with ferritin, Creactive protein, and estimated glomerular filtration rate.CONCLUSIONS. The findings indicate that IGF-1 is associated with key markers of protein and lipid metabolism, iron status, and inflammation. The strongest inverse association was observed between IGF-1 and ferritin levels, suggesting a potential role of IGF-1 in iron metabolism regulation. However, most of the observed associations, while statistically significant, lack strong clinical relevance. These relationships warrant further investigation in longitudinal studies.

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The authors declare that there are no conflicts of interest present.