<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-3-2020-243-249</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-62</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Немедикаментозная терапия когнитивных расстройств</article-title><trans-title-group xml:lang="en"><trans-title>Non-pharmacological therapies of cognitive impairment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2196-1068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маневич</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manevich</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маневич Татьяна Михайловна - кандидат медицинских наук, заведующая отделением гериатрической неврологии, ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр.</p><p>Москва.</p><p>Телефон: +7(903) 675-88-02</p></bio><bio xml:lang="en"><p>MD, PhD, Head of the Neurology department Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow</p><p>+7(903) 675-88-02</p></bio><email xlink:type="simple">Nadezda5775@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2597-981X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мхитарян</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mkhitaryan</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мхитарян Элен Араиковна - кандидат медицинских наук, доцент кафедры болезней старения ФДПО ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, старший научный сотрудник лаборатории общей гериатрии Российского геронтологического научно-клинического центра ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России.</p><p>Москва.</p><p>Телефон: +7(916) 653-36-78</p></bio><bio xml:lang="en"><p>MD, PhD of the Department of Aging Diseases, Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow.</p><p>+7(916) 653-36-78</p></bio><email xlink:type="simple">melen99@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>243</fpage><lpage>249</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маневич Т.М., Мхитарян Э.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Маневич Т.М., Мхитарян Э.А.</copyright-holder><copyright-holder xml:lang="en">Manevich T.M., Mkhitaryan E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/62">https://www.geriatr-news.com/jour/article/view/62</self-uri><abstract><p>Нарушения когнитивных функций являются одним из наиболее частых расстройств у людей пожилого и старческого возраста. В данной статье обсуждаются современные методы немедикаментозной терапии когнитивных расстройств на додементной стадии и стадии лёгкой деменции. Особое внимание уделено методам когнитивной реабилитации пациентов с нейродегенеративными и постинсультными нарушениями. Обсуждаются различные влияния нейропластичности головного мозга и церебрального когнитивного резерва. Анализируется взаимосвязь эффективности сочетанного применения физических упражнений и когнитивного тренинга, а также влияние особенностей кровоснабжения гипппокампа на когнитивный резерв.</p></abstract><trans-abstract xml:lang="en"><p>Cognitive disturbances are very frequent problems of the aged people. The review is dedicated to the modern methods of nonpharmacologic treatment of the predemention stage and mild dementia. There are data of reviews and meta-analysis of cognitive rehabilitation of the neurodegenerative and post-stroke cognitive disturbances. The mechanisms of brain neuroplasticity and the phenomenon of cognitive cerebral reserve are discussed. The relationship between effectiveness of the aerobic exercises and cognitive training is analysed and the influence of the hyppocamp blood supply on the cognitive reserve is also discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>немедикаментозное лечение</kwd><kwd>когнитивная реабилитация</kwd><kwd>нейропластичность</kwd><kwd>когнитивный резерв</kwd><kwd>компьютерный тренинг</kwd><kwd>физическая активность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nonpharmacological treatment</kwd><kwd>cognitive rehabilitation</kwd><kwd>cognitive reserve</kwd><kwd>computer training</kwd><kwd>physical activity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно Н.Н., Захаров В.В., Локшина А.Б., Коберская Н.Н., Мхитарян Э.А. Деменции. Руководство для врачей. 3-е изд. М.: Медпресс-информ; 2011. https://www.03book.ru/upload/iblock/987/415_Demencija_Jahno.pdf</mixed-citation><mixed-citation xml:lang="en">Яхно Н.Н., Захаров В.В., Локшина А.Б., Коберская Н.Н., Мхитарян Э.А. Деменции. Руководство для врачей. 3-е изд. М.: Медпресс-информ; 2011. https://www.03book.ru/upload/iblock/987/415_Demencija_Jahno.pdf</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Захаров В.В. Распространенность и лечение когнитивных нарушений в неврологической клинике (Результаты Всероссийского исследования «ПРОМЕТЕЙ») /Consilium medicum, 2008; №10(2); стр. 25-29.</mixed-citation><mixed-citation xml:lang="en">Захаров В.В. Распространенность и лечение когнитивных нарушений в неврологической клинике (Результаты Всероссийского исследования «ПРОМЕТЕЙ») /Consilium medicum, 2008; №10(2); стр. 25-29.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно Н.Н. Когнитивные расстройства в неврологической клинике. Неврологический журнал. 2006; 11(1): 4-12.</mixed-citation><mixed-citation xml:lang="en">Яхно Н.Н. Когнитивные расстройства в неврологической клинике. Неврологический журнал. 2006; 11(1): 4-12.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society. 2002; (8): 448-460. DOI: 10.1017/S1355617702813248.</mixed-citation><mixed-citation xml:lang="en">Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society. 2002; (8): 448-460. DOI: 10.1017/S1355617702813248.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ball K., Berch D.B., Helmers K.F. et al. Effects of Cognitive Training Interventions With Older Adults. A Randomized Controlled Trial. JAMA 2002; (288): 2271-2281. DOI: 10.1001/jama.288.18.2271.</mixed-citation><mixed-citation xml:lang="en">Ball K., Berch D.B., Helmers K.F. et al. Effects of Cognitive Training Interventions With Older Adults. A Randomized Controlled Trial. JAMA 2002; (288): 2271-2281. DOI: 10.1001/jama.288.18.2271.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Clare L., Wu Y-T, Teale J.C. et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med. 2017; 14(3): 1549-1676. https://doi.org/10.1371/journal.pmed.1002259</mixed-citation><mixed-citation xml:lang="en">Clare L., Wu Y-T, Teale J.C. et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med. 2017; 14(3): 1549-1676. https://doi.org/10.1371/journal.pmed.1002259</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Perosa V.R.J. et al. Hippocampal vascular reserve associated with cognitive performance and hippocampal volume. Brain. 2020; 143 (3): 622-634. DOI: 10.1093/brain/awz383.</mixed-citation><mixed-citation xml:lang="en">Perosa V.R.J. et al. Hippocampal vascular reserve associated with cognitive performance and hippocampal volume. Brain. 2020; 143 (3): 622-634. DOI: 10.1093/brain/awz383.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Waldron-Perrine B., Axelrod B.N. Determining an appropriate cutting score for indication of impairment on the Montreal Cognitive Assessment. Int J Geriatr Psychiatry. 2012; 27(11): 1189-94. DOI: 10.1002/gps.3768.</mixed-citation><mixed-citation xml:lang="en">Waldron-Perrine B., Axelrod B.N. Determining an appropriate cutting score for indication of impairment on the Montreal Cognitive Assessment. Int J Geriatr Psychiatry. 2012; 27(11): 1189-94. DOI: 10.1002/gps.3768.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Coen R.F., Cahill R., Lawlor B.A. Things to watch out for when using the Montreal cognitive assessment (MoCA). Int J Geriatr Psychiatry. 2011; 26(1): 107-8. DOI: 10.1002/gps.2471.</mixed-citation><mixed-citation xml:lang="en">Coen R.F., Cahill R., Lawlor B.A. Things to watch out for when using the Montreal cognitive assessment (MoCA). Int J Geriatr Psychiatry. 2011; 26(1): 107-8. DOI: 10.1002/gps.2471.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Beeri M.S., Sonnen J. Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression /Neurology. 2016, 86(8): 702703. DOI: 10.1212/WNL.0000000000002389.</mixed-citation><mixed-citation xml:lang="en">Beeri M.S., Sonnen J. Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression /Neurology. 2016, 86(8): 702703. DOI: 10.1212/WNL.0000000000002389.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vevoda J., Vevoda S., Souskova A. Influence of canistherapy against anxiety and depression of alder adults. 2nd International Multidisciplinary Scientific Conference on Social Sciences and Arts SGEM2015 Conference Proceedings, ISBN 978- 619- 7105- 445 / ISSN 2367-5659 , Aug 26-Sept 01; Book 1, (1): 101-108. DOI: 10.5593/SGEMSOCIAL2015/B11/S1.014.</mixed-citation><mixed-citation xml:lang="en">Vevoda J., Vevoda S., Souskova A. Influence of canistherapy against anxiety and depression of alder adults. 2nd International Multidisciplinary Scientific Conference on Social Sciences and Arts SGEM2015 Conference Proceedings, ISBN 978- 619- 7105- 445 / ISSN 2367- 5659 , Aug 26-Sept 01; Book 1, (1): 101-108. DOI: 10.5593/SGEMSOCIAL2015/B11/S1.014.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Woods B., Aguirre E., Spector A.E., Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012; (2): CD005562. DOI: 10.1002/14651858.CD005562.pub2.</mixed-citation><mixed-citation xml:lang="en">Woods B., Aguirre E., Spector A.E., Orrell M. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012; (2): CD005562. DOI: 10.1002/14651858.CD005562.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Unverzagt F.W., Smith D.M., Rebok G.W. et al. The Indiana Alzheimer Disease Center's Symposium on Mild Cognitive Impairment. Cognitive Training in Older Adults: Lessons from the ACTIVE Study. Current Alzheimer Research. 2009; (6): 375-383. DOI: 10.2174/156720509788929345.</mixed-citation><mixed-citation xml:lang="en">Unverzagt F.W., Smith D.M., Rebok G.W. et al. The Indiana Alzheimer Disease Center's Symposium on Mild Cognitive Impairment. Cognitive Training in Older Adults: Lessons from the ACTIVE Study. Current Alzheimer Research. 2009; (6): 375-383. DOI: 10.2174/156720509788929345.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Finn M., McDonald S. Computerized cognitive training for older persons with mild cognitive impairment: A pilot study using a randomised controlled trial design. Brain Impairment. 2011; 12(3): 187-199. DOI: 10.1375/brim.12.3.187.</mixed-citation><mixed-citation xml:lang="en">Finn M., McDonald S. Computerized cognitive training for older persons with mild cognitive impairment: A pilot study using a randomised controlled trial design. Brain Impairment. 2011; 12(3): 187-199. DOI: 10.1375/brim.12.3.187.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cavallo M., Hunter E.M., van der Hiele K., Angilletta C. Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study. Arch Clin Neuropsychol. 2016: 1-9. DOI: 10.1093/arclin/acw072.</mixed-citation><mixed-citation xml:lang="en">Cavallo M., Hunter E.M., van der Hiele K., Angilletta C. Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study. Arch Clin Neuropsychol. 2016: 1-9. DOI: 10.1093/arclin/acw072.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Giuli C., Fattoretti P., Gagliardi C. et al. My Mind Project: the effects of cognitive training for elderly—the study protocol of a prospective randomized intervention study/Aging Clin Exp Res., 2017; (29): 353-360. DOI: 10.1007/s40520-016-0570-1.</mixed-citation><mixed-citation xml:lang="en">Giuli C., Fattoretti P., Gagliardi C. et al. My Mind Project: the effects of cognitive training for elderly—the study protocol of a prospective randomized intervention study/Aging Clin Exp Res., 2017; (29): 353-360. DOI: 10.1007/s40520-016-0570-1.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Giuli C., Papa R., Lattanzio F., Postacchini D. The Effects of Cognitive Training for Elderly: Results from My Mind Project. Rejuvenation res. 2016; V.19(6): 485-494. DOI: 10.1089/rej.2015.1791.</mixed-citation><mixed-citation xml:lang="en">Giuli C., Papa R., Lattanzio F., Postacchini D. The Effects of Cognitive Training for Elderly: Results from My Mind Project. Rejuvenation res. 2016; V.19(6): 485-494. DOI: 10.1089/rej.2015.1791.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Krell-Roesch J. Quantity and quality of mental activities and the risk of incident mild cognitive im-pairment/Neurology., 2019; 93 (6): р.548-558. DOI: 10.1212/WNL.0000000000007897.</mixed-citation><mixed-citation xml:lang="en">Krell-Roesch J. Quantity and quality of mental activities and the risk of incident mild cognitive impairment/Neurology., 2019; 93 (6): р.548-558. DOI: 10.1212/WNL.0000000000007897.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Min-Ji Kim, Chang-Wan Han, Kyoung-Youn Min et al. Physical Exercise with Multicomponent Cognitive Intervention for Older Adults with Alzheimer's Disease: A 6-Month Randomized Controlled Trial. Dement Geriatr Cogn Dis Extra. 2016 May-Aug; 6(2): 222-232. DOI: 10.1159/000446508.</mixed-citation><mixed-citation xml:lang="en">Min-Ji Kim, Chang-Wan Han, Kyoung-Youn Min et al. Physical Exercise with Multicomponent Cognitive Intervention for Older Adults with Alzheimer's Disease: A 6-Month Randomized Controlled Trial. Dement Geriatr Cogn Dis Extra. 2016 May-Aug; 6(2): 222-232. DOI: 10.1159/000446508.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Eyre H.A., Acevedo B., Yang H. et al. Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study. J Alzheimers Dis. 2016; 52(2): 673-84. DOI: 10.3233/JAD-150653.</mixed-citation><mixed-citation xml:lang="en">Eyre H.A., Acevedo B., Yang H. et al. Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study. J Alzheimers Dis. 2016; 52(2): 673-84. DOI: 10.3233/JAD-150653.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dinoff A., Herrmann N., Swardfager W. et al. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS One. 2016; 11(9). DOI: 10.1371/journal.pone.0163037.</mixed-citation><mixed-citation xml:lang="en">Dinoff A., Herrmann N., Swardfager W. et al. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS One. 2016; 11(9). DOI: 10.1371/journal.pone.0163037.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ohman H., Savikko N., Strandberg T.E., Kautiainen et al. Effects of Exercise on Cognition: The Finnish Alzheimer Disease Exercise Trial: A Randomized, Controlled Trial. J Am Geriatr Soc. 2016; 64(4): 731-8. DOI: 10.1111/jgs.14059.</mixed-citation><mixed-citation xml:lang="en">Ohman H., Savikko N., Strandberg T.E., Kautiainen et al. Effects of Exercise on Cognition: The Finnish Alzheimer Disease Exercise Trial: A Randomized, Controlled Trial. J Am Geriatr Soc. 2016; 64(4): 731-8. DOI: 10.1111/jgs.14059.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Brinke L.F., Bolandzadeh N., Nagamatsu L.S. et al. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial.Br J Sports Med. 2015; 49(4): 248-254. DOI: 10.1136/bjsports-2013-093184.</mixed-citation><mixed-citation xml:lang="en">Brinke L.F., Bolandzadeh N., Nagamatsu L.S. et al. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial.Br J Sports Med. 2015; 49(4): 248-254. DOI: 10.1136/bjsports-2013-093184.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S., Luo X., Barnes D., Sano M., Yaffe K. Physical activity and risk of cognitive impairment among oldest-old women. Am. J. Geriatr. Psychiatry. 2014; 22(11): 1149-57. DOI: 10.1016/j.jagp.2013.03.002.</mixed-citation><mixed-citation xml:lang="en">Wang S., Luo X., Barnes D., Sano M., Yaffe K. Physical activity and risk of cognitive impairment among oldest-old women. Am. J. Geriatr. Psychiatry. 2014; 22(11): 1149-57. DOI: 10.1016/j.jagp.2013.03.002.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">https://www.who.int/mental_health/neurology/dementia/guidelines_risk_reduction/en/</mixed-citation><mixed-citation xml:lang="en">https://www.who.int/mental_health/neurology/dementia/guidelines_risk_reduction/en/</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sungkarat S., Boripuntakul S., Chattipakorn N. et al. Effects of Tai Chi on Cognition and Fall Risk in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial. J Am Geriatr Soc. 2017; 65(4): 721-727. DOI: 10.1111/jgs.14594.</mixed-citation><mixed-citation xml:lang="en">Sungkarat S., Boripuntakul S., Chattipakorn N. et al. Effects of Tai Chi on Cognition and Fall Risk in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial. J Am Geriatr Soc. 2017; 65(4): 721-727. DOI: 10.1111/jgs.14594.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Chan, J., Deng, K., Wu, J., &amp; Yan, J. Effects of Meditation and Mind-Body Exercises on Older Adults' Cognitive Performance: A Meta-analysis. The Gerontologist. 2019; 59(6), e782-e790. DOI: 10.1093/geront/gnz022.</mixed-citation><mixed-citation xml:lang="en">Chan, J., Deng, K., Wu, J., &amp; Yan, J. Effects of Meditation and Mind-Body Exercises on Older Adults' Cognitive Performance: A Meta-analysis. The Gerontologist. 2019; 59(6), e782-e790. DOI: 10.1093/geront/gnz022.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tsutsumimoto K., D oi T., Nakakubo S. Impact of Social Frailty on Alzheimer's Disease Onset/ Journal of Alzheimer's Disease. 2019; 70(2): 587-595. DOI: 10.3233/JAD-181178.</mixed-citation><mixed-citation xml:lang="en">Tsutsumimoto K., D oi T., Nakakubo S. Impact of Social Frailty on Alzheimer's Disease Onset/ Journal of Alzheimer's Disease. 2019; 70(2): 587-595. DOI: 10.3233/JAD-181178.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Liao X., Li G., Wang A., Liu T. et al. Repetitive Transcranial Magnetic Stimulation as an Alternative Therapy for Cognitive Impairment in Alzheimer's Disease: A Meta-Analysis. J. Alzheimers Dis. 2015; 48(2): 463-472. DOI: 10.3233/JAD-150346.</mixed-citation><mixed-citation xml:lang="en">Liao X., Li G., Wang A., Liu T. et al. Repetitive Transcranial Magnetic Stimulation as an Alternative Therapy for Cognitive Impairment in Alzheimer's Disease: A Meta-Analysis. J. Alzheimers Dis. 2015; 48(2): 463-472. DOI: 10.3233/JAD-150346.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Hill N., Mowszowski L., Naismith S. et al. Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis. The American Journal of Psyhiatry. 2017; 174(4): 329-340. DOI: 10.1176/appi.ajp.2016.16030360.</mixed-citation><mixed-citation xml:lang="en">Hill N., Mowszowski L., Naismith S. et al. Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis. The American Journal of Psyhiatry. 2017; 174(4): 329-340. DOI: 10.1176/appi.ajp.2016.16030360.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Vemuri P., Fields J., Peter J., Kloppel S. Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging. Current Opinion in Neurology. 2016; 29(4): 405-411. DOI: 10.1097/WCO.0000000000000346.</mixed-citation><mixed-citation xml:lang="en">Vemuri P., Fields J., Peter J., Kloppel S. Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging. Current Opinion in Neurology. 2016; 29(4): 405-411. DOI: 10.1097/WCO.0000000000000346.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Leung I.H.K., Walton C.C., Hallock H., Lewis S.J.G., Valenzuela M., Lampit A. Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology 2015; (85): 1843-1851. DOI: 10.1212/WNL.0000000000002145.</mixed-citation><mixed-citation xml:lang="en">Leung I.H.K., Walton C.C., Hallock H., Lewis S.J.G., Valenzuela M., Lampit A. Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology 2015; (85): 1843-1851. DOI: 10.1212/WNL.0000000000002145.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Bunketorp-Kall L., Lundgren-Nilsson A., Samuelsson H. et al. Long-Term Improvements After Multimodal Rehabilitation in Late Phase After Stroke A Randomized Controlled Trial. Stroke. 2017; (48). DOI: 10.1161/STROKEAHA.116.016433.</mixed-citation><mixed-citation xml:lang="en">Bunketorp-Kall L., Lundgren-Nilsson A., Samuelsson H. et al. Long-Term Improvements After Multimodal Rehabilitation in Late Phase After Stroke A Randomized Controlled Trial. Stroke. 2017; (48). DOI: 10.1161/STROKEAHA.116.016433.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Clare L., Wu Y-T., Teale J.C. et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med 2017; 14(3): e1002259. DOI: 10.1371/journal.pmed.1002259.</mixed-citation><mixed-citation xml:lang="en">Clare L., Wu Y-T., Teale J.C. et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med 2017; 14(3): e1002259. DOI: 10.1371/journal.pmed.1002259.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Douglas S., James I., Ballard C. Non-pharmacological interventions in dementia. Advances in Psychiatric Treatment. 2004; (10): 171-179. DOI: 10.1192/apt.10.3.171.</mixed-citation><mixed-citation xml:lang="en">Douglas S., James I., Ballard C. Non-pharmacological interventions in dementia. Advances in Psychiatric Treatment. 2004; (10): 171-179. DOI: 10.1192/apt.10.3.171.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
