RELEVANCE. Peri-implantitis is one of the leading causes of dental implant failure, particularly in elderly patients with impaired osteogenesis. Age-related changes, osteoporosis, osteopenia, and comorbid conditions such as diabetes mellitus and cardiovascular diseases reduce the regenerative potential of bone tissue, complicating the treatment of peri-implantitis. Standard treatment methods for peri-implantitis often prove insufficiently effective, as they do not account for individual variations in bone metabolism. Therefore, the development of personalized approaches based on the assessment of biochemical markers of osteogenesis, radiographic bone density, and systemic risk factors is a crucial objective in modern dentistry.