geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-2-2020-147-153geriatr-35Research ArticleОБЗОРЫREVIEWSСтарение костной тканиAging bonehttps://orcid.org/0000-0002-1216-0787БраиловаН. В.BrailovaN. V.

Браилова Наталья Васильевна, канд. мед. наук, младший научный сотрудник лаборатории возрастных и метаболических нарушений

eLibrary SPIN: 2900-8384

Москва

MD, PhD, junior research fellow, laboratory of age-related endocrine and metabolic disorders

eLibrary SPIN: 2900-8384

Moscow

n.kokshagina@mail.ruhttps://orcid.org/0000-0003-0816-4870КузнецоваВ. А.KuznetsovaV. A.

Кузнецова Вероника Андреевна, студентка

eLibrary SPIN: 8617-4030

Москва

Student

eLibrary SPIN: 8617-4030

Moscow

nik_k_ot@mail.ruhttps://orcid.org/0000-0001-7891-6850ДудинскаяЕ. Н.DudinskayaE. N.

Дудинская Екатерина Наильевна, канд. мед. наук, заведующая лабораторией возрастных эндокринных и метаболических нарушений

телефон: +7(903) 191-46-90

Москва

MD, PhD, Head of age-related endocrine and metabolic disorders laboratory

+7(903) 191-46-90

Moscow

katharina.gin@gmail.comhttps://orcid.org/0000-0002-4193-688XТкачеваО. Н.TkachevaO. N.

Ткачева Ольга Николаевна, д-р мед. наук, профессор, директор

телефон: +7(499) 187-64-67

Москва

MD, PhD, professor, Director

+7(499) 187-64-67

Moscow

tkacheva@rgnkc.ruФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Clinical and Research Center of GerontologyRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияPirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationRussian Federation20202505202002147153Copyright © Браилова Н.В., Кузнецова В.А., Дудинская Е.Н., Ткачева О.Н., 20202020Браилова Н.В., Кузнецова В.А., Дудинская Е.Н., Ткачева О.Н.Brailova N.V., Kuznetsova V.A., Dudinskaya E.N., Tkacheva O.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/35

Данная обзорная статья посвящена теме изменений, происходящих в костной ткани в процессе старения организма. Затрагивается адипогенез и остеогенез на молекулярном уровне, описываются белки и гены, в которых в процессе старения может произойти соматическая мутация, приводящая как к незначительным изменениям, так и к активной потере минеральной плотности кости. Перечисляются факторы, которые влияют на изменение минеральной плотности костей, преимущественно у людей пожилого возраста, и существующие лекарственные препараты, которые могут замедлить остеопороз. Знание клеточных и молекулярных механизмов, лежащих в основе старения костной ткани, будет способствовать созданию таргетной терапии остеопороза, замедляющей старение кости и предотвращающей падения и переломы у людей пожилого возраста.

This review article deals with the topic of changes in bone tissue in the process of aging of the body. Adipogenesis and osteogenesis are affected at the molecular level, proteins and genes are described, in which somatic mutation can occur during the aging process, resulting in both minor changes and an active loss of bone mineral density. The factors that affect the change in bone mineral density mainly in the elderly, and existing drugs that can slow down osteoporosis are listed. Knowledge of the cellular and molecular mechanisms underlying the aging of bone tissue will contribute to the creation of targeted therapy for osteoporosis, which slows down bone aging and prevents falls and fractures in the elderly people.

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The authors declare that there are no conflicts of interest present.