<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-4-2022-236-249</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-306</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Витамин К и возраст-ассоциированные заболевания</article-title><trans-title-group xml:lang="en"><trans-title>Vitamin K and age-related diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0048-268X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ерусланова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Eruslanova</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ерусланова Ксения Алексеевна - кандидат медицинских наук, заведующая лабораторией сердечно-сосудистого старения.</p><p>Москва, телефон: +7(499)187-78-09</p></bio><bio xml:lang="en"><p>Eruslanova Ksenia A. - MD, PhD, Head of Laboratory of Cardiovascular Aging.</p><p>Moscow +7(499)187-78-09</p></bio><email xlink:type="simple">Eruslanova_KA@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0556-1697</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онучина</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Onuchina</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Онучина Юлия Сергеевна - кандидат медицинских наук, научный сотрудник лаборатории возрастных метаболических и эндокринных нарушений.</p><p>Москва, телефон: +7(985)436-69-31</p></bio><bio xml:lang="en"><p>Onuchina Yulia S. - MD, PhD, research fellow, Age-related Endocrine and Metabolic Disorders Laboratory.Moscow +7(985)436-69-31</p></bio><email xlink:type="simple">onuchina90@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2764-1049</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванникова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivannikova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванникова Екатерина Владимировна - кандидат медицинских наук, старший научный сотрудник лаборатории возрастных метаболических и эндокринных нарушений, Scopus: 55342021000.</p><p>Москва</p></bio><bio xml:lang="en"><p>Izyumov Andrey D. - MD, geriatrician.</p><p>Moscow</p></bio><email xlink:type="simple">doc.ivannikova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7891-6850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудинская</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudinskaya</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дудинская Екатерина Наильевна - доктор медицинских наук, заведующая лабораторией возрастных метаболических и эндокринных нарушений.</p><p>Москва, телефон: +7(903)191-46-90</p></bio><bio xml:lang="en"><p>Dudinskaya Ekaterina N. - MD, PhD, professor, Head of Age-related Endocrine and Metabolic Disorders Laboratory, Russian Gerontology Research and Clinical Centre.</p><p>Moscow +7(903)191-46-90</p></bio><email xlink:type="simple">katharina.gin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр<country>Россия</country></aff><aff xml:lang="en">Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>02</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>236</fpage><lpage>249</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ерусланова К.А., Онучина Ю.С., Иванникова Е.В., Дудинская Е.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ерусланова К.А., Онучина Ю.С., Иванникова Е.В., Дудинская Е.Н.</copyright-holder><copyright-holder xml:lang="en">Eruslanova K.A., Onuchina Y.S., Ivannikova E.V., Dudinskaya E.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/306">https://www.geriatr-news.com/jour/article/view/306</self-uri><abstract><p>Витамин К относится к жирорастворимым витаминам, и его роль в обмене веществ, работе костной и соединительной тканей, а также свертывающей системе крови хорошо известна. Цель этого обзора — рассказать об участии двух витамеров витамина К — витамина К1 (филлохинон) и витамина К2 (менахиноны) — в патогенезе возраст-ассоциированных заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>Vitamin K is a fat-soluble vitamin and its role in metabolism, bone and connective tissue, and blood coagulation is well known. The purpose of this review is to identify and detail the involvement of two vitamin K vitamers, K1 or phylloquinone, and vitamin K2 or menaquinone, in the pathogenesis of age-related diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>питание</kwd><kwd>возраст-ассоциированные заболевания</kwd><kwd>витамин К</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>сосудистая кальцификация</kwd><kwd>антикоагулянты</kwd><kwd>падения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nutrition</kwd><kwd>age-associated diseases</kwd><kwd>vitamin K</kwd><kwd>cardiac ischemia</kwd><kwd>vascular calcification</kwd><kwd>anticoagulants</kwd><kwd>fall</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dam H., Schønheyder F. The occurrence and chemical nature of vitamin K. Biochem. J. 1936;30:897–901. DOI: 10.1042/bj0300897.</mixed-citation><mixed-citation xml:lang="en">Dam H., Schønheyder F. The occurrence and chemical nature of vitamin K. Biochem. J. 1936;30:897–901. DOI: 10.1042/bj0300897.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Shearer M.J., Newman P. Metabolism and cell biology of vitamin K. Thromb. Haemost. 2017;100:530–547.</mixed-citation><mixed-citation xml:lang="en">Shearer M.J., Newman P. Metabolism and cell biology of vitamin K. Thromb. Haemost. 2017;100:530–547.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rishavy M.A., Berkner K.L. Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr. 2012 Mar 1;3(2):135–48. DOI: 10.3945/an.111.001719. PMID: 22516721; PMCID: PMC3648714.</mixed-citation><mixed-citation xml:lang="en">Rishavy M.A., Berkner K.L. Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr. 2012 Mar 1;3(2):135–48. DOI: 10.3945/an.111.001719. PMID: 22516721; PMCID: PMC3648714.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kuwabara A., Uenishi K., Tanaka K. Vitamin K intake and health, consideration from the epidemiological studies. J Clin Biochem Nutr. 2021 Sep;69(2):111–121. DOI: 10.3164/jcbn.20-64. Epub 2021 Mar 25. PMID: 34616102; PMCID: PMC8482381.</mixed-citation><mixed-citation xml:lang="en">Kuwabara A., Uenishi K., Tanaka K. Vitamin K intake and health, consideration from the epidemiological studies. J Clin Biochem Nutr. 2021 Sep;69(2):111–121. DOI: 10.3164/jcbn.20-64. Epub 2021 Mar 25. PMID: 34616102; PMCID: PMC8482381.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Booth S.L. Vitamin K: Food composition and dietary intakes. Food Nutr. Res. 2017;56:5505. DOI: 10.3402/fnr.v56i0.5505.</mixed-citation><mixed-citation xml:lang="en">Booth S.L. Vitamin K: Food composition and dietary intakes. Food Nutr. Res. 2017;56:5505. DOI: 10.3402/fnr.v56i0.5505.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shearer M.J., Newman P. Metabolism and cell biology of vitamin K. Thromb. Haemost. 2017;100:530–547.</mixed-citation><mixed-citation xml:lang="en">Shearer M.J., Newman P. Metabolism and cell biology of vitamin K. Thromb. Haemost. 2017;100:530–547.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001.</mixed-citation><mixed-citation xml:lang="en">Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">U.S. Department of Agriculture, Agricultural Research Service. FoodData Centralexternal link disclaimer, 2019.</mixed-citation><mixed-citation xml:lang="en">U.S. Department of Agriculture, Agricultural Research Service. FoodData Centralexternal link disclaimer, 2019.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tarento T.D.C., McClure D.D., Talbot A.M., Regtop H.L., Biffin J.R., Valtchev P., Dehghani F., Kavanagh J.M. A potential biotechnological process for the sustainable production of vitamin K 1. Crit. Rev. Biotechnol. 2018;69:1–19. DOI: 10.1080/07388551.2018.1474168.</mixed-citation><mixed-citation xml:lang="en">Tarento T.D.C., McClure D.D., Talbot A.M., Regtop H.L., Biffin J.R., Valtchev P., Dehghani F., Kavanagh J.M. A potential biotechnological process for the sustainable production of vitamin K 1. Crit. Rev. Biotechnol. 2018;69:1–19. DOI: 10.1080/07388551.2018.1474168.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Marles R.J., Roe A.L., Oketch-Rabah H.A. US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K. Nutr. Rev. 2017;75:553–578. DOI: 10.1093/nutrit/nux022</mixed-citation><mixed-citation xml:lang="en">Marles R.J., Roe A.L., Oketch-Rabah H.A. US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K. Nutr. Rev. 2017;75:553–578. DOI: 10.1093/nutrit/nux022</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Akbulut A.C., Pavlic A., Petsophonsakul P., Halder M., Maresz K., Kramann R., Schurgers L. Vitamin K2 Needs an RDI Separate from Vitamin K1. Nutrients. 2020 Jun 21;12(6):1852. DOI: 10.3390/nu12061852. PMID: 32575901; PMCID: PMC7353270.</mixed-citation><mixed-citation xml:lang="en">Akbulut A.C., Pavlic A., Petsophonsakul P., Halder M., Maresz K., Kramann R., Schurgers L. Vitamin K2 Needs an RDI Separate from Vitamin K1. Nutrients. 2020 Jun 21;12(6):1852. DOI: 10.3390/nu12061852. PMID: 32575901; PMCID: PMC7353270.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vermeer C., Raes J., van t Hoofd C., Knapen M., Xanthoulea S. Menaquinone Content of Cheese. Nutrients. 2018;10:446. DOI: 10.3390/nu10040446.</mixed-citation><mixed-citation xml:lang="en">Vermeer C., Raes J., van t Hoofd C., Knapen M., Xanthoulea S. Menaquinone Content of Cheese. Nutrients. 2018;10:446. DOI: 10.3390/nu10040446.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez-Fuentes A., Rivera-Caravaca J.M., López-Gálvez R., Marín F., Roldán V. Non-vitamin K Antagonist Oral Anticoagulants and Drug-Food Interactions: Implications for Clinical Practice and Potential Role of Probiotics and Prebiotics. Front Cardiovasc Med. 2022 Jan 17;8:787235. DOI: 10.3389/fcvm.2021.787235. PMID: 35111826; PMCID: PMC8801490.</mixed-citation><mixed-citation xml:lang="en">Sánchez-Fuentes A., Rivera-Caravaca J.M., López-Gálvez R., Marín F., Roldán V. Non-vitamin K Antagonist Oral Anticoagulants and Drug-Food Interactions: Implications for Clinical Practice and Potential Role of Probiotics and Prebiotics. Front Cardiovasc Med. 2022 Jan 17;8:787235. DOI: 10.3389/fcvm.2021.787235. PMID: 35111826; PMCID: PMC8801490.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fusaro M., Mereu M.C., Aghi A., Iervasi G.G.M. Vitamin K and bone. Clinical Cases in Mineral and Bone Metabolism. 2017;14(2):200–206. DOI: 10.11138/ccmbm/2017.14.1.200.</mixed-citation><mixed-citation xml:lang="en">Fusaro M., Mereu M.C., Aghi A., Iervasi G.G.M. Vitamin K and bone. Clinical Cases in Mineral and Bone Metabolism. 2017;14(2):200–206. DOI: 10.11138/ccmbm/2017.14.1.200.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Myneni V., Mezey E. Regulation of bone remodeling by vitamin K2. Oral Diseases. 2017;23(8):1021–1028. DOI: 10.1111/odi.12624.</mixed-citation><mixed-citation xml:lang="en">Myneni V., Mezey E. Regulation of bone remodeling by vitamin K2. Oral Diseases. 2017;23(8):1021–1028. DOI: 10.1111/odi.12624.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Akbari S., Rasouli-Ghahroudi A.A. Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies. BioMed Research International. 2018;2018:8. DOI: 10.1155/2018/4629383.4629383</mixed-citation><mixed-citation xml:lang="en">Akbari S., Rasouli-Ghahroudi A.A. Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies. BioMed Research International. 2018;2018:8. DOI: 10.1155/2018/4629383.4629383</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Halder M., Petsophonsakul P., Akbulut A.C., Pavlic A., Bohan F., Anderson E., Maresz K., Kramann R., Schurgers L. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci. 2019 Feb 19;20(4):896. DOI: 10.3390/ijms20040896. PMID: 30791399; PMCID: PMC6413124.</mixed-citation><mixed-citation xml:lang="en">Halder M., Petsophonsakul P., Akbulut A.C., Pavlic A., Bohan F., Anderson E., Maresz K., Kramann R., Schurgers L. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci. 2019 Feb 19;20(4):896. DOI: 10.3390/ijms20040896. PMID: 30791399; PMCID: PMC6413124.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tie J., Stafford D. Structural and functional insights into enzymes of the vitamin K cycle. J. Thromb. Haemost. 2016;14:236– 247. DOI: 10.1111/jth.13217.</mixed-citation><mixed-citation xml:lang="en">Tie J., Stafford D. Structural and functional insights into enzymes of the vitamin K cycle. J. Thromb. Haemost. 2016;14:236– 247. DOI: 10.1111/jth.13217.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Park D., Kim D.Y., Byun M.R., Hwang H., Ko S.H., Baek J.H., Baek K. Undercarboxylated, But Not Carboxylated, Osteocalcin Suppresses TNF-α-Induced Inflammatory Signaling Pathway in Myoblasts. J Endocr Soc. 2022 May 29;6(8):bvac084. DOI: 10.1210/jendso/bvac084. PMID: 35702666; PMCID: PMC9188654.</mixed-citation><mixed-citation xml:lang="en">Park D., Kim D.Y., Byun M.R., Hwang H., Ko S.H., Baek J.H., Baek K. Undercarboxylated, But Not Carboxylated, Osteocalcin Suppresses TNF-α-Induced Inflammatory Signaling Pathway in Myoblasts. J Endocr Soc. 2022 May 29;6(8):bvac084. DOI: 10.1210/jendso/bvac084. PMID: 35702666; PMCID: PMC9188654.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Berkner K.L., Runge K.W. Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease. Int J Mol Sci. 2022 May 20;23(10):5759. DOI: 10.3390/ijms23105759. PMID: 35628569; PMCID: PMC9146348.</mixed-citation><mixed-citation xml:lang="en">Berkner K.L., Runge K.W. Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease. Int J Mol Sci. 2022 May 20;23(10):5759. DOI: 10.3390/ijms23105759. PMID: 35628569; PMCID: PMC9146348.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chatron N., Hammed A., Benoît E., Lattard V. Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1. Nutrients. 2019 Jan 1;11(1):67. DOI: 10.3390/nu11010067. PMID: 30609653; PMCID: PMC6357001.</mixed-citation><mixed-citation xml:lang="en">Chatron N., Hammed A., Benoît E., Lattard V. Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1. Nutrients. 2019 Jan 1;11(1):67. DOI: 10.3390/nu11010067. PMID: 30609653; PMCID: PMC6357001.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rishavy M.A., Berkner K.L. Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr. 2012 Mar 1;3(2):135–48. DOI: 10.3945/an.111.001719. PMID: 22516721; PMCID: PMC3648714.</mixed-citation><mixed-citation xml:lang="en">Rishavy M.A., Berkner K.L. Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr. 2012 Mar 1;3(2):135–48. DOI: 10.3945/an.111.001719. PMID: 22516721; PMCID: PMC3648714.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fujii S., Shimizu A., Takeda N., Oguchi K., Katsurai T. Systematic synthesis and anti-inflammatory activity of x-carboxylated menaquinone derivatives. Investigations on identified and putative vitamin K2 metabolites. Bioorg. Med. Chem. 2015;23:2344–2352. DOI: 10.1016/j.bmc.2015.03.070.</mixed-citation><mixed-citation xml:lang="en">Fujii S., Shimizu A., Takeda N., Oguchi K., Katsurai T. Systematic synthesis and anti-inflammatory activity of x-carboxylated menaquinone derivatives. Investigations on identified and putative vitamin K2 metabolites. Bioorg. Med. Chem. 2015;23:2344–2352. DOI: 10.1016/j.bmc.2015.03.070.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mangge H., Prueller F., Dawczynski C., Curcic P., Sloup Z., Holter M., Herrmann M., Meinitzer A. Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients. Antioxidants (Basel). 2022 Jun 24;11(7):1235. DOI: 10.3390/antiox11071235. PMID: 35883726; PMCID: PMC9312339.</mixed-citation><mixed-citation xml:lang="en">Mangge H., Prueller F., Dawczynski C., Curcic P., Sloup Z., Holter M., Herrmann M., Meinitzer A. Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients. Antioxidants (Basel). 2022 Jun 24;11(7):1235. DOI: 10.3390/antiox11071235. PMID: 35883726; PMCID: PMC9312339.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Aksoy A., Al Zaidi M., Repges E., Becher M.U., Müller C., Oldenburg J., Zimmer S., Nickenig G., Tiyerili V. Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 (VKORC1L1) Inhibition Induces a Proliferative and Pro-inflammatory Vascular Smooth Muscle Cell Phenotype. Front Cardiovasc Med. 2021 Oct 27;8:708946. DOI: 10.3389/fcvm.2021.708946. PMID: 34778390; PMCID: PMC8578699.</mixed-citation><mixed-citation xml:lang="en">Aksoy A., Al Zaidi M., Repges E., Becher M.U., Müller C., Oldenburg J., Zimmer S., Nickenig G., Tiyerili V. Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 (VKORC1L1) Inhibition Induces a Proliferative and Pro-inflammatory Vascular Smooth Muscle Cell Phenotype. Front Cardiovasc Med. 2021 Oct 27;8:708946. DOI: 10.3389/fcvm.2021.708946. PMID: 34778390; PMCID: PMC8578699.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Emekli-Alturfan E., Alturfan A.A. The emerging relationship between vitamin K and neurodegenerative diseases: a review of current evidence. Mol Biol Rep. 2022 Nov 3. DOI: 10.1007/s11033-022-07925-w. Epub ahead of print. PMID: 36329336.</mixed-citation><mixed-citation xml:lang="en">Emekli-Alturfan E., Alturfan A.A. The emerging relationship between vitamin K and neurodegenerative diseases: a review of current evidence. Mol Biol Rep. 2022 Nov 3. DOI: 10.1007/s11033-022-07925-w. Epub ahead of print. PMID: 36329336.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ambrożewicz E., Muszyńska M., Tokajuk G., Grynkiewicz G., Žarković N., Skrzydlewska E. Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxypatite-Based Biomaterials. Cells. 2019;8:325. DOI: 10.3390/cells8040325.</mixed-citation><mixed-citation xml:lang="en">Ambrożewicz E., Muszyńska M., Tokajuk G., Grynkiewicz G., Žarković N., Skrzydlewska E. Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxypatite-Based Biomaterials. Cells. 2019;8:325. DOI: 10.3390/cells8040325.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Stefaniak O., Dobrzyńska M., Drzymała-Czyż S., Przysławski J. Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements. Nutrients. 2022 Oct 30;14(21):4564. DOI: 10.3390/nu14214564. PMID: 36364826; PMCID: PMC9656789.</mixed-citation><mixed-citation xml:lang="en">Stefaniak O., Dobrzyńska M., Drzymała-Czyż S., Przysławski J. Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements. Nutrients. 2022 Oct 30;14(21):4564. DOI: 10.3390/nu14214564. PMID: 36364826; PMCID: PMC9656789.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Li S., Kim H.E. Implications of Sphingolipids on Aging and Age-Related Diseases. Front Aging. 2022 Mar 3;2:797320. DOI: 10.3389/fragi.2021.797320. PMID: 35822041; PMCID: PMC9261390.</mixed-citation><mixed-citation xml:lang="en">Li S., Kim H.E. Implications of Sphingolipids on Aging and Age-Related Diseases. Front Aging. 2022 Mar 3;2:797320. DOI: 10.3389/fragi.2021.797320. PMID: 35822041; PMCID: PMC9261390.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lev M., Milford A. The 3-Ketodihydrosphingosine melaninogenicus: Synthetase of Bacteroides melaninogenicus: Induction by Vitamin K. Arch. Biochem. Biophys. 1973;157:500– 508. DOI: 10.1016/0003-9861(73)90668-1.</mixed-citation><mixed-citation xml:lang="en">Lev M., Milford A. The 3-Ketodihydrosphingosine melaninogenicus: Synthetase of Bacteroides melaninogenicus: Induction by Vitamin K. Arch. Biochem. Biophys. 1973;157:500– 508. DOI: 10.1016/0003-9861(73)90668-1.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sundaram K.S., Lev M. Warfarin administration reduces synthesis of sulfatides and other sphingolipids in mouse brain. J. Lipid Res. 1988;29:1475–1479.</mixed-citation><mixed-citation xml:lang="en">Sundaram K.S., Lev M. Warfarin administration reduces synthesis of sulfatides and other sphingolipids in mouse brain. J. Lipid Res. 1988;29:1475–1479.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Booth S.L., Shea M.K., Barger K., Leurgans S.E., James B.D., Holland T.M., Agarwal P., Fu X., Wang J., Matuszek G., Schneider J.A. Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons. Alzheimers Dement (N Y). 2022 Apr 20;8(1):e12255. DOI: 10.1002/trc2.12255. PMID: 35475263; PMCID: PMC9019903.</mixed-citation><mixed-citation xml:lang="en">Booth S.L., Shea M.K., Barger K., Leurgans S.E., James B.D., Holland T.M., Agarwal P., Fu X., Wang J., Matuszek G., Schneider J.A. Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons. Alzheimers Dement (N Y). 2022 Apr 20;8(1):e12255. DOI: 10.1002/trc2.12255. PMID: 35475263; PMCID: PMC9019903.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sundaram K.S., Engelke J.A., Foley A.L., Suttie J., Lev M. Vitamin K Status Influences Brain Sulfatide Metabolism in Young Mice and Rats. J. Nutr. 1996;126:2746–2751</mixed-citation><mixed-citation xml:lang="en">Sundaram K.S., Engelke J.A., Foley A.L., Suttie J., Lev M. Vitamin K Status Influences Brain Sulfatide Metabolism in Young Mice and Rats. J. Nutr. 1996;126:2746–2751</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Chen X., Furukawa N., Jin D.Y., Liu Y., Stafford D.W., Williams C.M., Suhara Y., Tie J.K. Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation. FEBS J. 2022 May;289(9):2613–2627. DOI: 10.1111/febs.16291. Epub 2021 Dec 1. PMID: 34813684; PMCID: PMC9064899.</mixed-citation><mixed-citation xml:lang="en">Chen X., Furukawa N., Jin D.Y., Liu Y., Stafford D.W., Williams C.M., Suhara Y., Tie J.K. Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation. FEBS J. 2022 May;289(9):2613–2627. DOI: 10.1111/febs.16291. Epub 2021 Dec 1. PMID: 34813684; PMCID: PMC9064899.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ding H., Reiss A.B., Pinkhasov A., Kasselman L.J. Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. Medicina (Kaunas). 2022 Jul 30;58(8):1025. DOI: 10.3390/medicina58081025. PMID: 36013492; PMCID: PMC9414574.</mixed-citation><mixed-citation xml:lang="en">Ding H., Reiss A.B., Pinkhasov A., Kasselman L.J. Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. Medicina (Kaunas). 2022 Jul 30;58(8):1025. DOI: 10.3390/medicina58081025. PMID: 36013492; PMCID: PMC9414574.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Xv F., Chen J., Duan L., Li S. Research progress on the anticancer effects of vitamin K2. Oncol Lett. 2018 Jun;15(6):89268934. DOI: 10.3892/ol.2018.8502. Epub 2018 Apr 16. PMID: 29805627; PMCID: PMC5958717.</mixed-citation><mixed-citation xml:lang="en">Xv F., Chen J., Duan L., Li S. Research progress on the anticancer effects of vitamin K2. Oncol Lett. 2018 Jun;15(6):89268934. DOI: 10.3892/ol.2018.8502. Epub 2018 Apr 16. PMID: 29805627; PMCID: PMC5958717.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Markowska A., Antoszczak M., Markowska J., Huczyński A. Role of Vitamin K in Selected Malignant Neoplasms in Women. Nutrients. 2022 Aug 18;14(16):3401. DOI: 10.3390/nu14163401. PMID: 36014904; PMCID: PMC9413298.</mixed-citation><mixed-citation xml:lang="en">Markowska A., Antoszczak M., Markowska J., Huczyński A. Role of Vitamin K in Selected Malignant Neoplasms in Women. Nutrients. 2022 Aug 18;14(16):3401. DOI: 10.3390/nu14163401. PMID: 36014904; PMCID: PMC9413298.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Dasari S., Ali S.M., Zheng G., Chen A., Dontaraju V.S., Bosland M.C., Kajdacsy-balla A., Gnanasekar M. Vitamin K and its analogs: Potential avenues for prostate cancer management. Oncotarget. 2017;8:57782–57799. DOI: 10.18632/oncotarget.17997.</mixed-citation><mixed-citation xml:lang="en">Dasari S., Ali S.M., Zheng G., Chen A., Dontaraju V.S., Bosland M.C., Kajdacsy-balla A., Gnanasekar M. Vitamin K and its analogs: Potential avenues for prostate cancer management. Oncotarget. 2017;8:57782–57799. DOI: 10.18632/oncotarget.17997.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Simes D.C. et al. Vitamin K as a diet supplement with impact in human health: current evidence in age-related diseases // Nutrients. — 2020. — Т. 12. — №. 1. — С. 138.</mixed-citation><mixed-citation xml:lang="en">Simes D.C. et al. Vitamin K as a diet supplement with impact in human health: current evidence in age-related diseases // Nutrients. — 2020. — Т. 12. — №. 1. — С. 138.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L., Hsiao F., Shen L., Wu F.L., Tsay W. Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study. PLoS ONE 2016, 27, e0158407.</mixed-citation><mixed-citation xml:lang="en">Chen L., Hsiao F., Shen L., Wu F.L., Tsay W. Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study. PLoS ONE 2016, 27, e0158407.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Vroonhof K., Van Rijn H.J.M., Van Hattum J. Vitamin K deficiency and bleeding after long-term use of cholestyramine. Neth. J. Med. 2003, 61, 19–21. MacWalter, R.; Fraser, H.; Armstrong, K. Orlistat Enhances Warfarin Effect. Ann. Pharmacother. 2003, 37, 510–512.</mixed-citation><mixed-citation xml:lang="en">Vroonhof K., Van Rijn H.J.M., Van Hattum J. Vitamin K deficiency and bleeding after long-term use of cholestyramine. Neth. J. Med. 2003, 61, 19–21. MacWalter, R.; Fraser, H.; Armstrong, K. Orlistat Enhances Warfarin Effect. Ann. Pharmacother. 2003, 37, 510–512.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ishizu T., Torii S., Taguchi M. Association between serum uncarboxylated osteocalcin levels and nutritional intake in Japanese female athletes. Phys Act Nutr. 2022 Sep;26(3):1–5. DOI: 10.20463/pan.2022.0012. Epub 2022 Sep 30. PMID: 36353824; PMCID: PMC9663258.</mixed-citation><mixed-citation xml:lang="en">Ishizu T., Torii S., Taguchi M. Association between serum uncarboxylated osteocalcin levels and nutritional intake in Japanese female athletes. Phys Act Nutr. 2022 Sep;26(3):1–5. DOI: 10.20463/pan.2022.0012. Epub 2022 Sep 30. PMID: 36353824; PMCID: PMC9663258.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Crintea A., Dutu A.G., Sovrea A., Constantin A.M., Samasca G., Masalar A.L., Ifju B., Linga E., Neamti L., Tranca R.A., Fekete Z., Silaghi C.N., Craciun A.M. Nanocarriers for Drug Delivery: An Overview with Emphasis on Vitamin D and K Transportation. Nanomaterials (Basel). 2022 Apr 17;12(8):1376. DOI: 10.3390/nano12081376. PMID: 35458084; PMCID: PMC9024560.</mixed-citation><mixed-citation xml:lang="en">Crintea A., Dutu A.G., Sovrea A., Constantin A.M., Samasca G., Masalar A.L., Ifju B., Linga E., Neamti L., Tranca R.A., Fekete Z., Silaghi C.N., Craciun A.M. Nanocarriers for Drug Delivery: An Overview with Emphasis on Vitamin D and K Transportation. Nanomaterials (Basel). 2022 Apr 17;12(8):1376. DOI: 10.3390/nano12081376. PMID: 35458084; PMCID: PMC9024560.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou M., Han S., Zhang W., Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022 Sep;40(5):763–772. DOI: 10.1007/s00774022-01342-6. Epub 2022 Jun 16. PMID: 35711002.</mixed-citation><mixed-citation xml:lang="en">Zhou M., Han S., Zhang W., Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022 Sep;40(5):763–772. DOI: 10.1007/s00774022-01342-6. Epub 2022 Jun 16. PMID: 35711002.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Simes D.C., Viegas C.S.B., Araújo N., Marreiros C. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci. 2019 Aug 25;20(17):4150. DOI: 10.3390/ijms20174150. PMID: 31450694; PMCID: PMC6747195.</mixed-citation><mixed-citation xml:lang="en">Simes D.C., Viegas C.S.B., Araújo N., Marreiros C. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci. 2019 Aug 25;20(17):4150. DOI: 10.3390/ijms20174150. PMID: 31450694; PMCID: PMC6747195.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Rejnmark L., Vestergaard P., Charles P., Hermann A.P., Brot C., Eiken P., Mosekilde L. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos Int. 2006;17(8):1122–32. DOI: 10.1007/s00198-005-0044-3. Epub 2006 May 9. PMID: 16683180.</mixed-citation><mixed-citation xml:lang="en">Rejnmark L., Vestergaard P., Charles P., Hermann A.P., Brot C., Eiken P., Mosekilde L. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos Int. 2006;17(8):1122–32. DOI: 10.1007/s00198-005-0044-3. Epub 2006 May 9. PMID: 16683180.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Turck D., Bresson J.L., Burlingame B., Dean T., Fairweather-Tait S., Heinonen M., Hirsch-Ernst K.I., Mangelsdorf I., McArdle H.J., Naska A., Nowicka G., Pentieva K., Sanz Y., Siani A., Sjödin A., Stern M., Tomé D., Van Loveren H., Vinceti M., Willatts P., Lamberg-Allardt C., Przyrembel H., Tetens I., Dumas C., Fabiani L., Ioannidou S., Neuhäuser-Berthold M. Dietary reference values for vitamin K. EFSA J. 2017 May 22;15(5):e04780. DOI: 10.2903/j.efsa.2017.4780. PMID: 32625486; PMCID: PMC7010012.</mixed-citation><mixed-citation xml:lang="en">EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Turck D., Bresson J.L., Burlingame B., Dean T., Fairweather-Tait S., Heinonen M., Hirsch-Ernst K.I., Mangelsdorf I., McArdle H.J., Naska A., Nowicka G., Pentieva K., Sanz Y., Siani A., Sjödin A., Stern M., Tomé D., Van Loveren H., Vinceti M., Willatts P., Lamberg-Allardt C., Przyrembel H., Tetens I., Dumas C., Fabiani L., Ioannidou S., Neuhäuser-Berthold M. Dietary reference values for vitamin K. EFSA J. 2017 May 22;15(5):e04780. DOI: 10.2903/j.efsa.2017.4780. PMID: 32625486; PMCID: PMC7010012.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Apalset E.M., Gjesdal C.G., Eide G.E., Tell G.S. Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. Bone. 2011;49:990–995. DOI: 10.1016/j.bone.2011.07.035</mixed-citation><mixed-citation xml:lang="en">Apalset E.M., Gjesdal C.G., Eide G.E., Tell G.S. Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. Bone. 2011;49:990–995. DOI: 10.1016/j.bone.2011.07.035</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Shiraki M., Shiraki Y., Aoki C., Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J. Bone Miner. Res. 2000;15:515–521. DOI: 10.1359/jbmr.2000.15.3.515.</mixed-citation><mixed-citation xml:lang="en">Shiraki M., Shiraki Y., Aoki C., Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J. Bone Miner. Res. 2000;15:515–521. DOI: 10.1359/jbmr.2000.15.3.515.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Avenell A., Grey A., Gamble G.D., Bolland M.J. Concerns About the Integrity of the Yamaguchi Osteoporosis Prevention Study (YOPS) Report, Am J Med. 2004;117:549–555. Am J Med. 2020 Jun;133(6):e311–e314. DOI: 10.1016/j.amjmed.2020.02.007. PMID: 32532372.</mixed-citation><mixed-citation xml:lang="en">Avenell A., Grey A., Gamble G.D., Bolland M.J. Concerns About the Integrity of the Yamaguchi Osteoporosis Prevention Study (YOPS) Report, Am J Med. 2004;117:549–555. Am J Med. 2020 Jun;133(6):e311–e314. DOI: 10.1016/j.amjmed.2020.02.007. PMID: 32532372.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue T., Fujita T., Kishimoto H., Makino T., Nakamura T., Nakamura T., Sato T., Yamazaki K. Randomized controlled study on the prevention of osteoporotic fractures (OF Study): A phase IV clinical study of 15-mg menatetrenone capsules. J. Bone Miner. Metab. 2009;27:66–75. DOI: 10.1007/s00774-008-0008-8.</mixed-citation><mixed-citation xml:lang="en">Inoue T., Fujita T., Kishimoto H., Makino T., Nakamura T., Nakamura T., Sato T., Yamazaki K. Randomized controlled study on the prevention of osteoporotic fractures (OF Study): A phase IV clinical study of 15-mg menatetrenone capsules. J. Bone Miner. Metab. 2009;27:66–75. DOI: 10.1007/s00774-008-0008-8.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Z.B., Wan S.L., Lu Y.J., Ning L., Liu C., Fan S.W. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: A meta-analysis of randomized controlled trials. Osteoporos. Int. 2015;26:1175– 1186. DOI: 10.1007/s00198-014-2989-6.</mixed-citation><mixed-citation xml:lang="en">Huang Z.B., Wan S.L., Lu Y.J., Ning L., Liu C., Fan S.W. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: A meta-analysis of randomized controlled trials. Osteoporos. Int. 2015;26:1175– 1186. DOI: 10.1007/s00198-014-2989-6.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Mott A., Bradley T., Wright K., Cockayne E.S., Shearer M.J., Adamson J., Lanham-New S.A., Torgerson D.J. Effect of vitamin K on bone mineral density and fractures in adults: An updated systematic review and meta-analysis of randomised controlled trials. Osteoporos. Int. 2019;30:1543–1559. DOI: 10.1007/s00198-019-04949-0.</mixed-citation><mixed-citation xml:lang="en">Mott A., Bradley T., Wright K., Cockayne E.S., Shearer M.J., Adamson J., Lanham-New S.A., Torgerson D.J. Effect of vitamin K on bone mineral density and fractures in adults: An updated systematic review and meta-analysis of randomised controlled trials. Osteoporos. Int. 2019;30:1543–1559. DOI: 10.1007/s00198-019-04949-0.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Palermo A., Tuccinardi D., D’Onofrio L., Watanabe M., Maggi D., Maurizi A.R., Greto V., Buzzetti R., Napoli N., Pozzilli P., et al. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017;70:57–71. DOI: 10.1016/j.metabol.2017.01.032.</mixed-citation><mixed-citation xml:lang="en">Palermo A., Tuccinardi D., D’Onofrio L., Watanabe M., Maggi D., Maurizi A.R., Greto V., Buzzetti R., Napoli N., Pozzilli P., et al. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017;70:57–71. DOI: 10.1016/j.metabol.2017.01.032.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka S., Miyazaki T., Uemura Y., Kuroda T., Miyakawa N., Nakamura T., Fukunaga M., Ohashi Y., Ohta H., Mori S., et al. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03. J. Bone Miner. Metab. 2017;35:385–395. DOI: 10.1007/s00774-016-0768-5.</mixed-citation><mixed-citation xml:lang="en">Tanaka S., Miyazaki T., Uemura Y., Kuroda T., Miyakawa N., Nakamura T., Fukunaga M., Ohashi Y., Ohta H., Mori S., et al. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03. J. Bone Miner. Metab. 2017;35:385–395. DOI: 10.1007/s00774-016-0768-5.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Giri T.K., Newton D., Chaudhary O., Deych E., Napoli N., Villareal R., Diemer K., Milligan P.E., Gage F.B. Maximal doseresponse of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis. Int. J. Vitam. Nutr. Res. 2019:1–7. DOI: 10.1024/0300-9831/a000554.</mixed-citation><mixed-citation xml:lang="en">Giri T.K., Newton D., Chaudhary O., Deych E., Napoli N., Villareal R., Diemer K., Milligan P.E., Gage F.B. Maximal doseresponse of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis. Int. J. Vitam. Nutr. Res. 2019:1–7. DOI: 10.1024/0300-9831/a000554.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Neogi T., Booth S.L., Zhang Y.Q., Jacques P.F., Terkeltaub R., Aliabadi P., Felson D.T. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum. 2006;54:1255– 1261. DOI: 10.1002/art.21735.</mixed-citation><mixed-citation xml:lang="en">Neogi T., Booth S.L., Zhang Y.Q., Jacques P.F., Terkeltaub R., Aliabadi P., Felson D.T. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum. 2006;54:1255– 1261. DOI: 10.1002/art.21735.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Oka H., Akune T., Muraki S., En-yo Y., Yoshida M., Saika A., Sasaki S., Nakamura K., Kawaguchi H., Yoshimura N. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: Dietary survey in a populationbased cohort of the ROAD study. J. Orthop. Sci. 2009;14:687–692. DOI: 10.1007/s00776-009-1395-y.</mixed-citation><mixed-citation xml:lang="en">Oka H., Akune T., Muraki S., En-yo Y., Yoshida M., Saika A., Sasaki S., Nakamura K., Kawaguchi H., Yoshimura N. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: Dietary survey in a populationbased cohort of the ROAD study. J. Orthop. Sci. 2009;14:687–692. DOI: 10.1007/s00776-009-1395-y.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Misra D., Booth S.L., Tolstykh I., Felson D.T., Nevitt M.C., Lewis C.E., Torner J., Neogi T. Vitamin K deficiency is associated with incident knee osteoarthritis. Am. J. Med. 2013;126:243–248. DOI: 10.1016/j.amjmed.2012.10.011.</mixed-citation><mixed-citation xml:lang="en">Misra D., Booth S.L., Tolstykh I., Felson D.T., Nevitt M.C., Lewis C.E., Torner J., Neogi T. Vitamin K deficiency is associated with incident knee osteoarthritis. Am. J. Med. 2013;126:243–248. DOI: 10.1016/j.amjmed.2012.10.011.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Shea M.K., Kritchevsky S.B., Hsu F.C., Nevitt M., Booth S.L., Kwoh C.K., McAlindon T.E., Vermeer C., Drummen N., Harris T.B., et al. The association between vitamin K status and knee osteoarthritis features in older adults: The health, aging and body composition study. Osteoarthr. Cartil. 2015;23:370–378. DOI: 10.1016/j.joca.2014.12.008.</mixed-citation><mixed-citation xml:lang="en">Shea M.K., Kritchevsky S.B., Hsu F.C., Nevitt M., Booth S.L., Kwoh C.K., McAlindon T.E., Vermeer C., Drummen N., Harris T.B., et al. The association between vitamin K status and knee osteoarthritis features in older adults: The health, aging and body composition study. Osteoarthr. Cartil. 2015;23:370–378. DOI: 10.1016/j.joca.2014.12.008.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Chin K.Y., Pang K.L., Wong S.K., Chew D.C.H., Qodriyah H.M.S. Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review. Drugs Aging. 2022 Jul;39(7):487–504. DOI: 10.1007/s40266-022-00945-y. Epub 2022 May 30. PMID: 35635615.</mixed-citation><mixed-citation xml:lang="en">Chin K.Y., Pang K.L., Wong S.K., Chew D.C.H., Qodriyah H.M.S. Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review. Drugs Aging. 2022 Jul;39(7):487–504. DOI: 10.1007/s40266-022-00945-y. Epub 2022 May 30. PMID: 35635615.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Wallin R., Schurgers L.J., Loeser R.F. Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: A fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. Osteoarthr. Cartil. 2010;18:1096–1103. DOI: 10.1016/j.joca.2010.05.013.</mixed-citation><mixed-citation xml:lang="en">Wallin R., Schurgers L.J., Loeser R.F. Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: A fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. Osteoarthr. Cartil. 2010;18:1096–1103. DOI: 10.1016/j.joca.2010.05.013.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Silaghi C., Fodor D., Cristea V., Crãciun A.M. Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis. Clin. Chem. Lab. Med. 2012;50:125–128. DOI: 10.1515/cclm.2011.713.</mixed-citation><mixed-citation xml:lang="en">Silaghi C., Fodor D., Cristea V., Crãciun A.M. Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis. Clin. Chem. Lab. Med. 2012;50:125–128. DOI: 10.1515/cclm.2011.713.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Shea M.K., Kritchevsky S.B., Hsu F.C., Nevitt M., Booth S.L., Kwoh C.K., McAlindon T.E., Vermeer C., Drummen N., Harris T.B., et al. The association between vitamin K status and knee osteoarthritis features in older adults: The health, aging and body composition study. Osteoarthr. Cartil. 2015;23:370–378. DOI: 10.1016/j.joca.2014.12.008</mixed-citation><mixed-citation xml:lang="en">Shea M.K., Kritchevsky S.B., Hsu F.C., Nevitt M., Booth S.L., Kwoh C.K., McAlindon T.E., Vermeer C., Drummen N., Harris T.B., et al. The association between vitamin K status and knee osteoarthritis features in older adults: The health, aging and body composition study. Osteoarthr. Cartil. 2015;23:370–378. DOI: 10.1016/j.joca.2014.12.008</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Neogi T., Felson D.T., Sarno R., Booth S.L. Vitamin K in hand osteoarthritis: Results from a randomised clinical trial. Ann. Rheum Dis. 2008;67:1570–1573. DOI: 10.1136/ard.2008.094771.</mixed-citation><mixed-citation xml:lang="en">Neogi T., Felson D.T., Sarno R., Booth S.L. Vitamin K in hand osteoarthritis: Results from a randomised clinical trial. Ann. Rheum Dis. 2008;67:1570–1573. DOI: 10.1136/ard.2008.094771.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Cavaco S., Viegas C.S., Rafael M.S., Ramos A., Magalhães J., Blanco F.J., Vermeer C., Simes D.C. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell. Mol. Life Sci. 2016;73:1051–1065. DOI: 10.1007/s00018-015-2033-9.</mixed-citation><mixed-citation xml:lang="en">Cavaco S., Viegas C.S., Rafael M.S., Ramos A., Magalhães J., Blanco F.J., Vermeer C., Simes D.C. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cell. Mol. Life Sci. 2016;73:1051–1065. DOI: 10.1007/s00018-015-2033-9.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Greene M.A., Loeser R.F. Aging-related inflammation in osteoarthritis. Osteoarthr. Cartil. 2015;23:1966–1971. DOI: 10.1016/j.joca.2015.01.008.</mixed-citation><mixed-citation xml:lang="en">Greene M.A., Loeser R.F. Aging-related inflammation in osteoarthritis. Osteoarthr. Cartil. 2015;23:1966–1971. DOI: 10.1016/j.joca.2015.01.008.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Mangge H., Prueller F., Dawczynski C., Curcic P., Sloup Z., Holter M., Herrmann M., Meinitzer A. Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients. Antioxidants (Basel). 2022 Jun 24;11(7):1235. DOI: 10.3390/antiox11071235. PMID: 35883726; PMCID: PMC9312339.</mixed-citation><mixed-citation xml:lang="en">Mangge H., Prueller F., Dawczynski C., Curcic P., Sloup Z., Holter M., Herrmann M., Meinitzer A. Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients. Antioxidants (Basel). 2022 Jun 24;11(7):1235. DOI: 10.3390/antiox11071235. PMID: 35883726; PMCID: PMC9312339.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Gough M., Singh D.K., Singh B., Kaushal D., Mehra S. System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection. Front Immunol. 2022 Oct 5;13:777733. DOI: 10.3389/fimmu.2022.777733. PMID: 36275677; PMCID: PMC9583676.</mixed-citation><mixed-citation xml:lang="en">Gough M., Singh D.K., Singh B., Kaushal D., Mehra S. System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection. Front Immunol. 2022 Oct 5;13:777733. DOI: 10.3389/fimmu.2022.777733. PMID: 36275677; PMCID: PMC9583676.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Jung S., Choi B.H., Joo N.S. Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition. Korean J Fam Med. 2022 Sep;43(5):277–289. DOI: 10.4082/kjfm.21.0227. Epub 2022 Sep 20. PMID: 36168899; PMCID: PMC9532189.</mixed-citation><mixed-citation xml:lang="en">Jung S., Choi B.H., Joo N.S. Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition. Korean J Fam Med. 2022 Sep;43(5):277–289. DOI: 10.4082/kjfm.21.0227. Epub 2022 Sep 20. PMID: 36168899; PMCID: PMC9532189.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Beulens J.W., Bots M.L., Atsma F., Bartelink M.L., Prokop M., Geleijnse J.M., Witteman J.C., Grobbee D.E., van der Schouw Y.T. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009:489–493. DOI: 10.1016/j.atherosclerosis.2008.07.010.</mixed-citation><mixed-citation xml:lang="en">Beulens J.W., Bots M.L., Atsma F., Bartelink M.L., Prokop M., Geleijnse J.M., Witteman J.C., Grobbee D.E., van der Schouw Y.T. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009:489–493. DOI: 10.1016/j.atherosclerosis.2008.07.010.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Geleijnse J.M., Vermeer C., Grobbee D.E., Schurgers L.J., Knapen M.H., van der Meer I.M., Hofman A., Witteman J.C. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study. J. Nutr. 2004;134:3100–3105. DOI: 10.1093/jn/134.11.3100.</mixed-citation><mixed-citation xml:lang="en">Geleijnse J.M., Vermeer C., Grobbee D.E., Schurgers L.J., Knapen M.H., van der Meer I.M., Hofman A., Witteman J.C. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study. J. Nutr. 2004;134:3100–3105. DOI: 10.1093/jn/134.11.3100.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Gast G.C., de Roos N.M., Sluijs I., Bots M.L., Beulens J.W., Geleijnse J.M., Witteman J.C., Grobbee D.E., Peeters P.H., van der Schouw Y.T. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr. Metab. Cardiovasc. Dis. 2009;19:504–510. DOI: 10.1016/j.numecd.2008.10.004.</mixed-citation><mixed-citation xml:lang="en">Gast G.C., de Roos N.M., Sluijs I., Bots M.L., Beulens J.W., Geleijnse J.M., Witteman J.C., Grobbee D.E., Peeters P.H., van der Schouw Y.T. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr. Metab. Cardiovasc. Dis. 2009;19:504–510. DOI: 10.1016/j.numecd.2008.10.004.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Lai Y., Masatoshi H., Ma Y., Guo Y., Zhang B. Role of Vitamin K in Intestinal Health. Front Immunol. 2022 Jan 5;12:791565. DOI: 10.3389/fimmu.2021.791565. PMID: 35069573; PMCID: PMC8769504.</mixed-citation><mixed-citation xml:lang="en">Lai Y., Masatoshi H., Ma Y., Guo Y., Zhang B. Role of Vitamin K in Intestinal Health. Front Immunol. 2022 Jan 5;12:791565. DOI: 10.3389/fimmu.2021.791565. PMID: 35069573; PMCID: PMC8769504.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Karamzad N., Faraji E., Adeli S., Sullman M.J.M., Pourghassem Gargari B. The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial. Nutr Diabetes. 2022 Apr 1;12(1):15. DOI: 10.1038/s41387-02200192-5. PMID: 35365594; PMCID: PMC8976086.</mixed-citation><mixed-citation xml:lang="en">Karamzad N., Faraji E., Adeli S., Sullman M.J.M., Pourghassem Gargari B. The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial. Nutr Diabetes. 2022 Apr 1;12(1):15. DOI: 10.1038/s41387-02200192-5. PMID: 35365594; PMCID: PMC8976086.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">van Ballegooijen A.J., Beulens J.W. The role of Vitamin K status in cardiovascular health: Evidence from observational and clinical studies. Curr. Nutr. Rep. 2017;6:197–205. DOI: 10.1007/s13668-017-0208-8.</mixed-citation><mixed-citation xml:lang="en">van Ballegooijen A.J., Beulens J.W. The role of Vitamin K status in cardiovascular health: Evidence from observational and clinical studies. Curr. Nutr. Rep. 2017;6:197–205. DOI: 10.1007/s13668-017-0208-8.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Barrett H., O’Keeffe M., Kavanagh E., Walsh M., O’Connor E.M. Is matrix Gla protein associated with vascular calcification? A systematic review. Nutrients. 2018;10:415. DOI: 10.3390/nu10040415.</mixed-citation><mixed-citation xml:lang="en">Barrett H., O’Keeffe M., Kavanagh E., Walsh M., O’Connor E.M. Is matrix Gla protein associated with vascular calcification? A systematic review. Nutrients. 2018;10:415. DOI: 10.3390/nu10040415.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Puzantian H., Akers S.R., Oldland G., Javaid K., Miller R., Ge Y., Ansari B., Lee J., Suri A., Hasmath Z., et al. Circulating dephospho-uncarboxylated matrix Gla-protein is associated with kidney dysfunction and arterial stiffness. Am. J. Hypertens. 2018;31:988– 994. DOI: 10.1093/ajh/hpy079.</mixed-citation><mixed-citation xml:lang="en">Puzantian H., Akers S.R., Oldland G., Javaid K., Miller R., Ge Y., Ansari B., Lee J., Suri A., Hasmath Z., et al. Circulating dephospho-uncarboxylated matrix Gla-protein is associated with kidney dysfunction and arterial stiffness. Am. J. Hypertens. 2018;31:988– 994. DOI: 10.1093/ajh/hpy079.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Sardana M., Vasim I., Varakantam S., Kewan U., Tariq A., Koppula M.R., Syed A.A., Beraun M., Drummen N.E., Vermeer C., Akers S.R., Chirinos J.A. Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus. Am J Hypertens. 2017 Feb;30(2):196–201. DOI: 10.1093/ajh/hpw146. Epub 2016 Dec 7. PMID: 27927630.</mixed-citation><mixed-citation xml:lang="en">Sardana M., Vasim I., Varakantam S., Kewan U., Tariq A., Koppula M.R., Syed A.A., Beraun M., Drummen N.E., Vermeer C., Akers S.R., Chirinos J.A. Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus. Am J Hypertens. 2017 Feb;30(2):196–201. DOI: 10.1093/ajh/hpw146. Epub 2016 Dec 7. PMID: 27927630.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Aoun M., Makki M., Azar H., Matta H., Chelala D.N. High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial. BMC Nephrol. 2017 Jun 7;18(1):191. DOI: 10.1186/s12882-017-0609-3. PMID: 28592319; PMCID: PMC5463325.</mixed-citation><mixed-citation xml:lang="en">Aoun M., Makki M., Azar H., Matta H., Chelala D.N. High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial. BMC Nephrol. 2017 Jun 7;18(1):191. DOI: 10.1186/s12882-017-0609-3. PMID: 28592319; PMCID: PMC5463325.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Seidlerová J., Wohlfahrt P., Filipovský J., Vaněk J., Cífková R., Windrichová J., Topolčan O., Knapen M.H., Drummen N.E., Vermeer C., et al. Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population. J. Hum. Hypertens. 2015;30:418–423. DOI: 10.1038/jhh.2015.55.</mixed-citation><mixed-citation xml:lang="en">Seidlerová J., Wohlfahrt P., Filipovský J., Vaněk J., Cífková R., Windrichová J., Topolčan O., Knapen M.H., Drummen N.E., Vermeer C., et al. Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population. J. Hum. Hypertens. 2015;30:418–423. DOI: 10.1038/jhh.2015.55.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Pivin E., Ponte B., Pruijm M., Ackermann D., Guessous I., Ehret G., Liu Y.P., Drummen N.E., Knapen M.H., Pechere-Bertschi A., et al. Inactive Matrix Gla-Protein Is associated with arterial stiffness in an adult population-based study. Hypertension. 2015;66:85–92. DOI: 10.1161/HYPERTENSIONAHA.115.05177.</mixed-citation><mixed-citation xml:lang="en">Pivin E., Ponte B., Pruijm M., Ackermann D., Guessous I., Ehret G., Liu Y.P., Drummen N.E., Knapen M.H., Pechere-Bertschi A., et al. Inactive Matrix Gla-Protein Is associated with arterial stiffness in an adult population-based study. Hypertension. 2015;66:85–92. DOI: 10.1161/HYPERTENSIONAHA.115.05177.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">van den Heuvel E.M., van Schoor N.M., Lips P., Magdeleyns E.P., Deeg D.H., Vermeer C., den Heijer M. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas. 2014;77:137– 141. DOI: 10.1016/j.maturitas.2013.10.008.</mixed-citation><mixed-citation xml:lang="en">van den Heuvel E.M., van Schoor N.M., Lips P., Magdeleyns E.P., Deeg D.H., Vermeer C., den Heijer M. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas. 2014;77:137– 141. DOI: 10.1016/j.maturitas.2013.10.008.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Hariri E., Kassis N., Iskandar J.P., Schurgers L.J., Saad A., Abdelfattah O., Bansal A., Isogai T., Harb S.C., Kapadia S. Vitamin K2-a neglected player in cardiovascular health: a narrative review. Open Heart. 2021 Nov;8(2):e001715. DOI: 10.1136/openhrt-2021-001715. PMID: 34785587; PMCID: PMC8596038.</mixed-citation><mixed-citation xml:lang="en">Hariri E., Kassis N., Iskandar J.P., Schurgers L.J., Saad A., Abdelfattah O., Bansal A., Isogai T., Harb S.C., Kapadia S. Vitamin K2-a neglected player in cardiovascular health: a narrative review. Open Heart. 2021 Nov;8(2):e001715. DOI: 10.1136/openhrt-2021-001715. PMID: 34785587; PMCID: PMC8596038.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Houston D.K., Tooze J.A., Neiberg R.H., Hausman D.B., Johnson M.A., Cauley J.A., Bauer D.C., Cawthon P.M., Shea M.K., Schwartz G.G., et al. 25-Hydroxyvitamin D status and change in physical performance and strength in older adults: The Health, Aging, and Body Composition Study. Am. J. Epidemiol. 2012;176:1025–1034. DOI: 10.1093/aje/kws147.</mixed-citation><mixed-citation xml:lang="en">Houston D.K., Tooze J.A., Neiberg R.H., Hausman D.B., Johnson M.A., Cauley J.A., Bauer D.C., Cawthon P.M., Shea M.K., Schwartz G.G., et al. 25-Hydroxyvitamin D status and change in physical performance and strength in older adults: The Health, Aging, and Body Composition Study. Am. J. Epidemiol. 2012;176:1025–1034. DOI: 10.1093/aje/kws147.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Shea M.K., Booth S.L., Weiner D.E., Brinkley T.E., Kanaya A.M., Murphy R.A., Simonsick E.M., Wassel C.L., Vermeer C., Kritchevsky S.B. Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC) J. Nutr. 2017;147:888–895. DOI: 10.3945/jn.117.249375.</mixed-citation><mixed-citation xml:lang="en">Shea M.K., Booth S.L., Weiner D.E., Brinkley T.E., Kanaya A.M., Murphy R.A., Simonsick E.M., Wassel C.L., Vermeer C., Kritchevsky S.B. Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC) J. Nutr. 2017;147:888–895. DOI: 10.3945/jn.117.249375.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang S., Guo L., Bu C. Vitamin K status and cardiovascular events or mortality: A meta-analysis. Eur. J. Prev. Cardiol. 2018;26:549–553. DOI: 10.1177/2047487318808066.</mixed-citation><mixed-citation xml:lang="en">Zhang S., Guo L., Bu C. Vitamin K status and cardiovascular events or mortality: A meta-analysis. Eur. J. Prev. Cardiol. 2018;26:549–553. DOI: 10.1177/2047487318808066.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Shea M.K., O’Donnell C.J., Vermeer C., Magdeleyns E.P., Crosier M.D., Gundberg C.M., Ordovas J.M., Kritchevsky S.B., Booth S.L. Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults. J. Nutr. 2011;141:1529–1534. DOI: 10.3945/jn.111.139634.</mixed-citation><mixed-citation xml:lang="en">Shea M.K., O’Donnell C.J., Vermeer C., Magdeleyns E.P., Crosier M.D., Gundberg C.M., Ordovas J.M., Kritchevsky S.B., Booth S.L. Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults. J. Nutr. 2011;141:1529–1534. DOI: 10.3945/jn.111.139634.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Dalmeijer G.W., van der Schouw Y.T., Magdeleyns E.J., Vermeer C., Verschuren W.M.M., Boer J.M., Beulens J.W.J. Circulating desphospho-uncarboxylated matrix γ-carboxyglutamate protein and the risk of coronary heart disease and stroke. J. Thromb. Haemost. 2014;12:1028–1034. DOI: 10.1111/jth.12609.</mixed-citation><mixed-citation xml:lang="en">Dalmeijer G.W., van der Schouw Y.T., Magdeleyns E.J., Vermeer C., Verschuren W.M.M., Boer J.M., Beulens J.W.J. Circulating desphospho-uncarboxylated matrix γ-carboxyglutamate protein and the risk of coronary heart disease and stroke. J. Thromb. Haemost. 2014;12:1028–1034. DOI: 10.1111/jth.12609.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Knapen M., Braam L., Drummen N., Bekers O., Hoeks A.G., Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. Thromb. Haemost. 2015;113:1135–1144. DOI: 10.1160/TH14-08-0675.</mixed-citation><mixed-citation xml:lang="en">Knapen M., Braam L., Drummen N., Bekers O., Hoeks A.G., Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. Thromb. Haemost. 2015;113:1135–1144. DOI: 10.1160/TH14-08-0675.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Holden R.M., Morton A.R., Garland J.S., Pavlov A., Day A.G., Booth S.L. Vitamins K and D status in stages 3–5 chronic kidney disease. Clin. J. Am. Soc. Nephrol. 2010;5:590–597. DOI: 10.2215/CJN.06420909.</mixed-citation><mixed-citation xml:lang="en">Holden R.M., Morton A.R., Garland J.S., Pavlov A., Day A.G., Booth S.L. Vitamins K and D status in stages 3–5 chronic kidney disease. Clin. J. Am. Soc. Nephrol. 2010;5:590–597. DOI: 10.2215/CJN.06420909.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Caluwé R., Vandecasteele S., Van Vlem B., Vermeer C., De Vriese A.S. Vitamin K2 supplementation in haemodialysis patients: A randomized dose-finding study. Nephrol. Dial. Transplant. 2014;29:1385–1390. DOI: 10.1093/ndt/gft464.</mixed-citation><mixed-citation xml:lang="en">Caluwé R., Vandecasteele S., Van Vlem B., Vermeer C., De Vriese A.S. Vitamin K2 supplementation in haemodialysis patients: A randomized dose-finding study. Nephrol. Dial. Transplant. 2014;29:1385–1390. DOI: 10.1093/ndt/gft464.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Aoun M., Makki M., Azar H., Matta H., Chelala D.N. High dephosphorylated-uncarboxylated MGP in hemodialysis patients: Risk factors and response to vitamin K2, a pre-post intervention clinical trial. BMC Nephrol. 2017;18:191. DOI: 10.1186/s12882-017-0609-3.</mixed-citation><mixed-citation xml:lang="en">Aoun M., Makki M., Azar H., Matta H., Chelala D.N. High dephosphorylated-uncarboxylated MGP in hemodialysis patients: Risk factors and response to vitamin K2, a pre-post intervention clinical trial. BMC Nephrol. 2017;18:191. DOI: 10.1186/s12882-017-0609-3.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Silva A.P., Viegas C.S., Simes D.C., Mendes F., Tavares N., Rato F., Santos N., Neves P.L. Gla-Rich Protein as a novel marker for calcifications in diabetic patients with CKD. Nephrol. Dial. Transpl. 2018;33:i493. DOI: 10.1093/ndt/gfy104.SP430.</mixed-citation><mixed-citation xml:lang="en">Silva A.P., Viegas C.S., Simes D.C., Mendes F., Tavares N., Rato F., Santos N., Neves P.L. Gla-Rich Protein as a novel marker for calcifications in diabetic patients with CKD. Nephrol. Dial. Transpl. 2018;33:i493. DOI: 10.1093/ndt/gfy104.SP430.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Violi F. et al. Interaction between dietary vitamin K intake and anticoagulation by vitamin K antagonists: is it really true?: a systematic review //Medicine. — 2016. — Т. 95. — № 10.</mixed-citation><mixed-citation xml:lang="en">Violi F. et al. Interaction between dietary vitamin K intake and anticoagulation by vitamin K antagonists: is it really true?: a systematic review //Medicine. — 2016. — Т. 95. — № 10.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Dashti H.S., Shea M.K., Smith C.E., et al. Meta-analysis of genomewide association studies for circulating phylloquinone concentrations. Am J Clin Nutr. 2014;100:1462–1469.</mixed-citation><mixed-citation xml:lang="en">Dashti H.S., Shea M.K., Smith C.E., et al. Meta-analysis of genomewide association studies for circulating phylloquinone concentrations. Am J Clin Nutr. 2014;100:1462–1469.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Pignatelli P., Pastori D., Vicario T., et al. Relationship between Mediterranean diet and time in therapeutic range in atrial fibrillation patients taking vitamin K antagonists. Europace. 2015;17.</mixed-citation><mixed-citation xml:lang="en">Pignatelli P., Pastori D., Vicario T., et al. Relationship between Mediterranean diet and time in therapeutic range in atrial fibrillation patients taking vitamin K antagonists. Europace. 2015;17.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">National Institutes of Health. Dietary Supplement Label Database. 2014.</mixed-citation><mixed-citation xml:lang="en">National Institutes of Health. Dietary Supplement Label Database. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Schurgers L.J., Teunissen K.J., Hamulyak K., Knapen M.H., Vik H., Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 2007;109:3279–83.</mixed-citation><mixed-citation xml:lang="en">Schurgers L.J., Teunissen K.J., Hamulyak K., Knapen M.H., Vik H., Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 2007;109:3279–83.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
