geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-2-2022-96-102geriatr-255Research ArticleОБЗОРЫREVIEWSМетаболизм мышечной ткани у лиц пожилого возрастаMuscle metabolism in older adultshttps://orcid.org/0000-0002-2764-1049ИванниковаЕ. В.IvannikovaE. V.

Москва

Moscow

https://orcid.org/0000-0001-7891-6850ДудинскаяЕ. Н.DudinskayaE. N.

Москва

Moscow

https://orcid.org/0000-0002-0556-1697ОнучинаЮ. С.OnuchinaYu. S.

Москва

Moscow

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov National Research Medical University, Russian Gerontology Research and Clinical CentreRussian Federation2022210720220296102Copyright © Иванникова Е.В., Дудинская Е.Н., Онучина Ю.С., 20222022Иванникова Е.В., Дудинская Е.Н., Онучина Ю.С.Ivannikova E.V., Dudinskaya E.N., Onuchina Y.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/255

Саркопения — генерализованное прогрессирующее заболевание скелетных мышц, которое ассоциировано с повышенным риском инвалидности и смертности вследствие падений и переломов. В статье подробно изложены современные сведения о возрастных особенностях метаболизма и ремоделирования мышечной ткани, которые приводят к развитию саркопении и её дальнейшему прогрессированию. Представлены возможности коррекции саркопении: разобран механизм действия экспериментальных лекарственных средств, действующих на мышечную ткань (миостатин, бимагрумаб, ландогрозумаб), а также доказавших эффективность немедикаментозных способов коррекции саркопении (питание, физические нагрузки), изложены возможные эффекты приёма препаратов витамина D для пациентов с саркопенией.

Sarcopenia is a generalized progressive skeletal muscle disease that is associated with an increased risk of disability and death due to falls and fractures. The article details current information about the age-related features of metabolism and muscle tissue remodeling, which lead to the development of sarcopenia and its further progression. The possibilities of correcting sarcopenia are presented: the mechanism of action of experimental drugs acting on muscle tissue (myostatin, bimagrumab, landogrosumab) and non-drug methods of correcting sarcopenia (nutrition, physical activity) that have proven the effectiveness of non-drug methods for correcting sarcopenia (nutrition, physical activity) are analyzed, and the possible effects of taking vitamin D preparations for patients with sarcopenia are described.

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The authors declare that there are no conflicts of interest present.