geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-1-2022-58-63geriatr-244Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESТроспия хлорид у больных пожилого возраста с идиопатическим гиперактивным мочевым пузыремTrospium chloride in older patients with idiopathic overactive urinary badderКривобородовГ. Г.KrivoborodovG. G.

 д-р мед. наук, профессор, профессор кафедры урологии и андрологии, заведующий урологическим отделением 

Москва

MD, PhD, professor of Urology and Andrology Department, Faculty of General Medicine; Head of Urology Department

 Moscow 

https://orcid.org/0000-0002-4193-688XТкачеваО. Н.TkachevaO. N.

 д-р мед. наук, профессор, директор 

телефон: +7(499)187-64-67

Москва

MD, PhD, professor, Director, Russian Gerontology Research and Clinical Centre+7(499)187-64-67 

 Moscow 

tkacheva@rgnkc.ruЕфремовН. С.EfremovN. S.

 канд. мед. наук, доцент

Москва

 MD, PhD, Assistant professor of Urology and Andrology Department, Faculty of General Medicine 

 Moscow 

ШиринД. А.ShyrinD. A.

 младший научный сотрудник лаборатории общей гериатрии, врач-уролог 

Москва

 MD, Junior Research Fellow of Geriatrics Laboratory

 Moscow 

ГонтарьА. А.GontarA. A.

Москва

Moscow 

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр; ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, кафедра урологии и андрологии лечебного факультетаРоссияPirogov Russian National Research Medical University; Pirogov Russian National Research Medical University, Department of Urology and Andrology, Faculty of General MedicineRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical UniversityRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, кафедра урологии и андрологии лечебного факультетаРоссияPirogov Russian National Research Medical University, Department of Urology and Andrology, Faculty of General MedicineRussian Federation202225052022015863Copyright © Кривобородов Г.Г., Ткачева О.Н., Ефремов Н.С., Ширин Д.А., Гонтарь А.А., 20222022Кривобородов Г.Г., Ткачева О.Н., Ефремов Н.С., Ширин Д.А., Гонтарь А.А.Krivoborodov G.G., Tkacheva O.N., Efremov N.S., Shyrin D.A., Gontar A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/244

Гиперактивный мочевой пузырь (ГМП) — это клинический синдром, определяющий ургентное мочеиспускание в сочетании или без ургентного недержания мочи, которое обычно сопровождается учащенным мочеиспусканием и ноктурией. В большинстве случаев ГМП не представляет угрозы для жизни пациентов, но значимо ухудшает качество всех сфер жизни человека. Ургентное недержание мочи — одна из основных причин падений больных пожилого возраста, что нередко приводит к переломам проксимального отдела бедра и сопровождается тяжёлыми осложнениями.Медикаментозная терапия м-холиноблокаторами (холинолитиками) является ведущим направлением в лечении больных ГМП. Однако её использование остаётся не до конца изученным у мужчин и женщин пожилого возраста.Выбор эффективного и безопасного холинолитика для больных пожилого и старческого возраста является предметом дискуссии и научных исследований. Полученные результаты показывают, что троспия хлорид является эффективным препаратом для лечения ургентного и учащенного мочеиспускания вследствие идиопатического ГМП и не оказывает влияния на когнитивную функцию у пожилых больных.

Overactive bladder (OAB) — is a clinical syndrome which includes urge urination with or without urge urinary incontinence which is usually accompanied by frequent urination and nocturia. In most cases, OAB does not pose a threat to the life of patients, but significantly worsens the quality of all spheres of human life. Urge urinary incontinence is one of the main causes of falls in older patients, which often leads to fractures of the proximal femur and is accompanied by severe complications. Drug therapy with M-cholinoblockers (cholinolytics) is the leading direction in the treatment of patients with OAB. However, this type of therapy remains poorly understood in older men and women. The choice of an effective and safe cholinolytic for older and senile patients is the subject of discussion and scientific research. The results obtained show trospium chloride as an effective drug for the treatment of urgent and frequent urination due to idiopathic OAB, as well as the lack of influence on cognitive function in older patients.

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The authors declare that there are no conflicts of interest present.