geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-1-2022-24-31geriatr-239Research ArticleОБЗОРЫREVIEWSОстеопороз и когнитивные расстройства у пожилых: есть ли связь?Osteoporosis and cognitive impairment in older adults: what is the link?https://orcid.org/0000-0002-9054-0881ЧердакМ. А.CherdakM. A.

канд. мед. наук, ассистент кафедры болезней старения ФДПО

телефон: +7(926)5604289

Москва 

 MD, PhD, Assistant Professor of Department of aging diseases, Faculty of additional professional education

+7(926)5604289 

 Moscow 

maria.cherdak@yandex.ruhttps://orcid.org/0000-0001-7891-6850ДудинскаяЕ. Н.DudinskayaE. N.

 канд. мед. наук, заведующая лабораторией возрастных метаболических и эндокринных нарушений телефон: +7(903)191-46-90

 Москва 

MD, PhD, Head of age-related endocrine and metabolic disorders laboratory

+7(903)191-46-90 

 Moscow 

katharina.gin@gmail.comФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical University, Russian Gerontology Research and Clinical CentreRussian Federation202224052022012431Copyright © Чердак М.А., Дудинская Е.Н., 20222022Чердак М.А., Дудинская Е.Н.Cherdak M.A., Dudinskaya E.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/239

Старение ассоциировано с развитием ряда специфических патологических состояний, среди которых особое место занимают остеопороз и различные когнитивные расстройства. Эпидемиологически установлено, что два этих состояния тесно связаны: наличие когнитивных нарушений повышает риск остеопороза, а среди пациентов с остеопорозом чаще выявляется деменция, в частности, вызванная болезнью Альцгеймера. Остеопороз у пациентов с деменцией представляет собой чрезвычайно серьезную проблему, поскольку развитие остеопоротических переломов чревато резким усугублением когнитивного статуса и существенным нарастанием инвалидности и смертности. Связь между изменением минеральной плотности костей и когнитивным статусом у пожилых изучена недостаточно. В обзоре приведены данные неклинических и клинических исследований, описывающих общие генетические и метаболические факторы, лежащие в основе патогенеза обсуждаемых патологических состояний, которые имеет смысл учитывать при планировании будущих клинических исследований как деменции, так и остеопороза.

Osteoporosis and various cognitive disorders occupy a special place among a number of specific pathological conditions associated with age. Epidemiologically these two conditions are closely related thus the presence of cognitive impairment increases the risk of osteoporosis; and, visa versa, dementia, in particular, caused by Alzheimer's disease, and is more often detected among patients with osteoporosis. Osteoporosis in patients with dementia is an extremely serious problem, since the development of osteoporotic fractures is fraught with a sharp deterioration in cognitive status and a significant increase in disability and mortality. The connection between changes in bone mineral density and cognitive status in older adults is not well understood. The review presents data from non-clinical and clinical studies that describe common genetic and metabolic factors underlying the pathogenesis of the pathological conditions under discussion, which should be taken into account when planning future dementia and osteoporosis clinical trials.

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The authors declare that there are no conflicts of interest present.