geriatrРоссийский журнал гериатрической медициныRussian Journal of Geriatric Medicine2686-86362686-8709Сайт издателя10.37586/2686-8636-3-2021-313-318geriatr-196Research ArticleОБЗОРЫREVIEWSПерспективы таргетной терапии неспецифической боли в спине: обзор последних публикацийPerspectives of targeted therapy for nonspecific back pain: a review of recent publicationshttps://orcid.org/0000-0002-2196-1068МаневичТ. М.ManevichT. M.

Москва

Moscow

https://orcid.org/0000-0003-2597-981XМхитарянЭ. А.MkhitaryanE. A.

Мхитарян Элен Араиковна, к.м.н., доцент кафедры болезней старения, старший научный сотрудник лаборатории общей гериатрии и нейрогериатрии ОСП

Москва

Mkhitaryan Elen Araikovna, PhD, senior researcher of the laboratory of General geriatrics and neurogeriatric

Moscow

https://orcid.org/0000-0002-6253-621XНаумовА. В.NaumovA. V.

Наумов Антон Вячеславович, д.м.н., заведующий лабораторией заболеваний костно-мышечной системы ОСП, профессор кафедры болезней старения

Москва

Naumov Anton Vyacheslavovich, MD, PhD, Professor, head of the laboratory of diseases of the musculoskeletal system

Moscow

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical University of Ministry of Health of the Russian Federation, Russian Gerontology Research and Clinical CentreRussian Federation20211410202103321326Copyright © Маневич Т.М., Мхитарян Э.А., Наумов А.В., 20212021Маневич Т.М., Мхитарян Э.А., Наумов А.В.Manevich T.M., Mkhitaryan E.A., Naumov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geriatr-news.com/jour/article/view/196

Высокая частота встречаемости боли в спине у лиц пожилого возраста, ее влияние на качество и продолжительность жизни, недостаточная эффективность существующих методов лечения определяют необходимость поиска методов лечения боли в спине, которые уменьшат воспалительно-дегенеративные изменения и непосредственно болевой синдром. В обзоре анализируется эпидемиология, патогенез, актуальные методы фармакотерапии боли в спине, роль генетических изменений и биомаркеров хронической боли, обсуждаются современные перспективы использования таргетной терапии для лечения хронических неспецифических болей в спине, основанные на патогенетических механизмах (генетические изменения, асептическое воспаление, иммунные нарушения, нарушения хондрогенеза и др.).

The high incidence of back pain in older people, its effect on quality and duration of life, and insufficient effectiveness of existing treatment methods determine the need to search for methods of back pain treatment that will reduce inflammatory and degenerative changes and the pain syndrome itself. The review analyzes the epidemiology, pathogenesis, current methods of pharmacotherapy for back pain, the role of genetic changes and biomarkers of chronic pain, discusses current prospects for the use of targeted therapy for the treatment of chronic nonspecific back pain based on pathogenetic mechanisms (genetic changes, aseptic inflammation, immune disorders, disorders of chondrogenesis, etc.).

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The authors declare that there are no conflicts of interest present.