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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-2-2021-201-208</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Первые результаты работы регистра пациентов с остеопорозом, включенных в службы профилактики повторных переломов</article-title><trans-title-group xml:lang="en"><trans-title>First results of the register of patients with osteoporosis included in the secondary fracture prevention services</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7856-1567</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белова</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Belova</surname><given-names>K. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белова Ксения Юрьевна - доктор медицинских наук, заведующая областным лечебно-диагностическим центром остеопороза, Клиническая больница скорой медицинской помощи имени Н.В. Соловьева; доцент кафедры терапии имени профессора Е.Н. Дормидонтова ЯГМУ Минздрава России.</p><p>Ярославль.</p><p>Тел.: +7(905)633-21-35</p></bio><bio xml:lang="en"><p>Belova Ksenia Yu. - MD, PhD, Head of Regional diagnostics and Treatment Osteoporosis Centre, Soloviev A&amp;E Clinical Hospital; assistant professor, Internal Diseases Department, named after prof. Dormidontov, Yaroslavl State Medical University.</p><p>Yaroslavl.</p><p>Tel.: +7(905)633-21-35</p></bio><email xlink:type="simple">ksbelova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2998-0893</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бублик</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bublik</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бублик Евгения Викторовна - доктор медицинских наук, врач-эндокринолог отделения эндокринологии, Центральная клиническая больница с поликлиникой при Управлении делами Президента Российской Федерации.</p><p>Москва.</p><p>Тел.: +7(926)160-43-24</p></bio><bio xml:lang="en"><p>Bublik Yevgnya V. - MD, PhD, endocrinologist of Endocrinology Department, Federal State Budgetary «Central clinical hospital with outpatient health center» of the Business Administration for the President of the Russian Federation.</p><p>Moscow.</p><p>Tel..: +7(926)160-43-24</p></bio><email xlink:type="simple">evb@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6689-6941</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гладкова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gladkova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гладкова Елена Николаевна - доктор медицинских наук, ассистент кафедры семейной медицины СЗГМУ им. И.И. Мечникова МЗ РФ; заведующая организационно-методическим и статистическим отделом, Клиническая ревматологическая больница № 25.</p><p>Санкт-Петербург.</p><p>Тел.: +7(982)651-44-04; +7(812)670-11-75</p></bio><bio xml:lang="en"><p>Gladkova Elena N. - MD, PhD, assistant of Family Medicine Department of the North-Western state medical University named after I.I. Mechnikov of the Russian Federation Ministry of Healthcare; Head of organizational-methodological and statistical Department of the Clinical rheumatology hospital № 25.</p><p>Sankt-Peterburg.</p><p>Tel.: +7(982)651-44-04; +7(812)670-11-75</p></bio><email xlink:type="simple">gen4605@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горджеладзе</surname><given-names>Х. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gordjeladze</surname><given-names>H. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горджеладзе Хатиа Геннадиевна - врач-ревматолог отделения плановой консультативной помощи с лечебно-диагностическим центром остеопороза , Клиническая больница скорой медицинской помощи имени Н.В. Соловьева.</p><p>Ярославль.</p><p>Тел.: +7(4852)28-30-55</p></bio><bio xml:lang="en"><p>Gordjeladze Hatia G. - MD, rheumatologist of the Department of planned consultative care with the osteoporosis treatment and diagnostic center, Soloviev A&amp;E Clinical Hospital.</p><p>Yaroslavl.</p><p>Tel.: +7(4852)28-30-55</p></bio><email xlink:type="simple">khatia911@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7891-6850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудинская</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudinskaya</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дудинская Екатерина Наильевна - доктор медицинских наук, заведующая лабораторией возрастных метаболических эндокринных нарушений РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр.</p><p>Москва.</p><p>Тел.: +7(903)191-46-90</p></bio><bio xml:lang="en"><p>Dudinskaya Ekaterina N. - MD, PhD, Head of age-related endocrine and metabolic disorders laboratory, Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow.</p><p>Tel.: +7(903)191-46-90</p></bio><email xlink:type="simple">katharina.gin@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6418-7060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ладыгина</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ladygina</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ладыгина Дарья Олеговна - доктор медицинских наук, Центральная клиническая больница с поликлиникой при Управлении делами Президента Российской Федерации.</p><p>Москва.</p><p>Тел.: +7(916)805-00-05</p></bio><bio xml:lang="en"><p>Ladygina Daria O. - MD, PhD, Federal State Budgetary «Central clinical hospital with outpatient health center» of the Business Administration for the President of the Russian Federation.</p><p>Moscow.</p><p>Tel.: +7(916)805-00-05</p></bio><email xlink:type="simple">ladygina.do@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Марина Сергеевна - врач-ревматолог отделения плановой консультативной помощи с лечебно-диагностическим центром остеопороза, Клиническая больница скорой медицинской помощи имени Н.В. Соловьева.</p><p>Ярославль.</p><p>Тел.: +7(4852)28-30-55</p></bio><bio xml:lang="en"><p>Morozova Marina S. - MD, rheumatologist of the department of planned consultative care with the osteoporosis treatment and diagnostic center, Soloviev A&amp;E Clinical Hospital.</p><p>Yaroslavl.</p><p>Tel.: +7(4852)28-30-55</p></bio><email xlink:type="simple">risha.77@bk.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3022-4166</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полякова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полякова Юлия Васильевна - доктор медицинских наук, заведующая консультативно-диагностическим отделением, научный сотрудник лаборатории методов лечения и профилактики заболеваний суставов, НИИ КиЭР им. А.Б. Зборовского.</p><p>Волгоград.</p><p>Тел.: +7(8442)78-90-98, +7(909)377-53-54</p></bio><bio xml:lang="en"><p>Polyakova Yulia V. - MD, PhD, Head of the Consultative and Diagnostic department, researcher of the laboratory of methods of treatment and prevention of joint diseases, Zborovsky Research Institute of Clinical and Experimental Rheumatology.</p><p>Volgograd.</p><p>Tel.: +7(8442)78-90-98, +7(909)377-53-54</p></bio><email xlink:type="simple">jpolyakova@yandex.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0965-6060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивордова</surname><given-names>Л. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivordova</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сивордова Лариса Евгеньевна - доктор медицинских наук, ведущий научный сотрудник лаборатории методов лечения и профилактики заболеваний суставов, НИИ КиЭР им. А.Б. Зборовского.</p><p>Волгоград.</p><p>Тел.: +7(8442)78-90-98, +7(902)095-09-99</p></bio><bio xml:lang="en"><p>Sivordova Larisa E. - MD, PhD, leading researcher of the laboratory of methods of treatment and prevention of joint diseases Federal State Budgetary Institution «Zborovsky Research Institute of Clinical and Experimental Rheumatology».</p><p>Volgograd.</p><p>Tel.: +7(8442)78-90-98, +7(902)095-09-99</p></bio><email xlink:type="simple">seeword@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5594-8526</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Танаев</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tanaev</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Танаев Вячеслав Генрихович - ревматолог, консультативно-диагностический центр профилактики остеопороза, СПб Клиническая ревматологическая больница № 25.</p><p>Санкт-Петербург.</p><p>Тел.: +7(812)246-73-39</p></bio><bio xml:lang="en"><p>Tanaev Vyacheslav G. - MD, rheumatologist of the Consultative and Diagnostic Center for Osteoporosis Prevention of the Clinical Rheumatology Hospital № 25.</p><p>Sankt-Peterburg.</p><p>Tel.: +7(812)246-73-39</p></bio><email xlink:type="simple">info@policlinica24.ru</email><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0143-0614</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лесняк</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lesnyak</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лесняк Ольга Михайловна - доктор медицинских наук, профессор, профессор кафедры семейной медицины СЗГМУ им. И.И. Мечникова Минздрава России; заведующая консультативно-диагностическим центром профилактики остеопороза, Клиническая ревматологическая больница № 25.</p><p>Санкт-Петербург.</p><p>Тел.: +7(965)814-07-01</p></bio><bio xml:lang="en"><p>Lesnyak Olga M. - MD, PhD, Professor, Professor of the Department of Family Medicine North-Western State Medical University named after I.I. Mechnikov of the Russian Federation Ministry of Healthcare; Head of the Consultative and Diagnostic Center for the Prevention of Osteoporosis of the Clinical Rheumatology Hospital № 25.</p><p>Sankt-Peterburg.</p><p>Tel.: +7(965)814-07-01</p></bio><email xlink:type="simple">olga.m.lesnyak@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Ярославский государственный медицинский университет МЗ РФ; Клиническая больница скорой медицинской помощи имени Н.В. Соловьева<country>Россия</country></aff><aff xml:lang="en">Yaroslavl State Medical University; Solovyov A&amp;E Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Центральная клиническая больница с поликлиникой при Управлении делами Президента Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Central clinical hospital with outpatient health center of the Business Administration for the President of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Северо-западный государственный медицинский университет им. И.И. Мечникова; Клиническая ревматологическая больница № 25<country>Россия</country></aff><aff xml:lang="en">North-Western state medical University named after I.I. Mechnikov; Clinical rheumatology hospital № 25<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Ярославский государственный медицинский университет МЗ РФ; Клиническая больница скорой медицинской помощи имени Н.В. Соловьева<country>Россия</country></aff><aff xml:lang="en">Solovyov A&amp;E Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава России<country>Россия</country></aff><aff xml:lang="en">Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru">Клиническая больница скорой медицинской помощи имени Н.В. Соловьева<country>Россия</country></aff><aff xml:lang="en">Solovyov A&amp;E Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru">Научно-исследовательский институт клинической и экспериментальной ревматологии имени А.Б. Зборовского<country>Россия</country></aff><aff xml:lang="en">Zborovsky Research Institute of Clinical and Experimental Rheumatology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru">Клиническая ревматологическая больница № 25<country>Россия</country></aff><aff xml:lang="en">Clinical rheumatology hospital № 25<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>01</day><month>08</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>211</fpage><lpage>218</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белова К.Ю., Бублик Е.В., Гладкова Е.Н., Горджеладзе Х.Г., Дудинская Е.Н., Ладыгина Д.О., Морозова М.С., Полякова Ю.В., Сивордова Л.Е., Танаев В.Г., Лесняк О.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Белова К.Ю., Бублик Е.В., Гладкова Е.Н., Горджеладзе Х.Г., Дудинская Е.Н., Ладыгина Д.О., Морозова М.С., Полякова Ю.В., Сивордова Л.Е., Танаев В.Г., Лесняк О.М.</copyright-holder><copyright-holder xml:lang="en">Belova K.Y., Bublik E.V., Gladkova E.N., Gordjeladze H.G., Dudinskaya E.N., Ladygina D.O., Morozova M.S., Polyakova Y.V., Sivordova L.E., Tanaev V.G., Lesnyak O.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/178">https://www.geriatr-news.com/jour/article/view/178</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Для снижения числа остеопоротических переломов в мире в последние годы создаются службы профилактики повторных переломов (СППП). В России с 2019 года начата разработка регистра пациентов, включенных в СППП, который был назван «Прометей».</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Создана информационная система для хранения, поиска и обработки информации, разработана регистрационная карта. В ведении регистра принимают участие 6 СППП. На 10.03.2021 в регистр внесены данные по 387 пациентам.</p></sec><sec><title>Результаты</title><p>Результаты. Среди включенных пациентов 46,25% получили перелом проксимального отдела бедренной кости, 20,41% — тел позвонков и 16,80% — проксимального отдела плечевой кости, у остальных отмечены переломы других локализаций. Оценка риска переломов выполнена у всех больных. Высокий риск основных остеопоротических переломов по FRAX определен у 160 (43,24%) человек. Двухэнергетическая рентгеновская абсорбциометрия (DXA) выполнена у 152 (39,28%) пациентов, остеопороз выявлен у 103 (67,76%) больных, остеопения — у 42 (27,63%) пациентов. Оценка риска падений выполнена у 100% включенных пациентов, риск падений определен как высокий у 343 (88,63%) больных. Оценка различных лабораторных параметров для поиска причин вторичного остеопороза выполнена у большинства пациентов. После консультации врача СППП антиостеопоротические препараты назначены 241 (64,27%) человеку. Среди остальных у 70 (52,24%) больных выявлены противопоказания и 31 (23,13%) человек нуждался в проведении дальнейшего обследования.</p></sec><sec><title>Выводы</title><p>Выводы. Таким образом, использование регистра позволяет оценить все основные разделы организации помощи внутри СППП и сравнить их с международными стандартами для выявления «пробелов» и совершенствования работы службы.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. To reduce the number of osteoporotic fractures in the world in recent years, — Fracture Liaison Service has been created. Since 2019, the development of a register of patients included in the Secondary Fracture Prevention named «Prometheus» has begun in Russia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. An information system for storing, searching and processing information has been created, and a registration card has been developed. Six FLS participate in the register management. As of 10.03.2021, data on 387 patients were introduced in the register.</p></sec><sec><title>Results</title><p>Results. Among the included patients, 46.25% received a fracture of the proximal femur, 20.41% — of the vertebral bodies and 16.80% of the proximal humerus, the rest had fractures of other localizations. The risk of fractures was assessed in all patients. A high risk of major osteoporotic fractures according to FRAX was determined in 160 (43.24%) people. Two-energy X-ray absorptiometry (DXA) was performed in 152 (39.28%) patients, and osteoporosis was detected in 103 (67.76%), osteopenia — in 42 (27.63%) patients. The risk of falls was assessed in 100% of the included patients, and the risk of falls was determined to be high in 343 (88.63%) patients. Evaluation of various laboratory parameters to find the causes of secondary osteoporosis was performed in most patients. After consultation with the FLS doctor, anti-osteoporotic drugs were prescribed to 241 (64.27%) people. Among the rest, 70 (52.24%) patients had contra-indications and 31 (23.13%) people needed further examination.</p></sec><sec><title>Conclusions</title><p>Conclusions. Thus, the use of the register allows you to evaluate all the main sections of the organization of assistance within the FLS and compare them with international standards to identify «gaps» and improve the work of the service.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>служба профилактики повторных переломов</kwd><kwd>низкоэнергетические переломы</kwd><kwd>FRAX</kwd><kwd>риск падений</kwd><kwd>регистр</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fracture liaison service</kwd><kwd>fragility fractures</kwd><kwd>FRAX</kwd><kwd>risk of falls</kwd><kwd>register</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк О.М. Аудит состояния проблемы остеопороза в странах Восточной Европы и Центральной Азии в 2010 году. Остеопороз и остеопатии. 2011; 2: 3-6.</mixed-citation><mixed-citation xml:lang="en">Lesnyak OM. Audit sostoyaniya problemy osteoporoza v stranah Vostochnoj Evropy i Central'noj Azii v 2010 godu. Osteoporoz i osteopatii. 2011; 2: 3-6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ganda K., Puech M., Chen J.S. et al. Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int. 2013; 24(2): 349-406. https://doi.org/10.1007/s00198-012-2090-y</mixed-citation><mixed-citation xml:lang="en">Ganda K., Puech M., Chen J.S. et al. Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int. 2013; 24(2): 349-406. https://doi.org/10.1007/s00198-012-2090-y</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17: 1726-1733. https://doi.org/10.1007/s00198-006-0172-4</mixed-citation><mixed-citation xml:lang="en">Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17: 1726-1733. https://doi.org/10.1007/s00198-006-0172-4</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Papaioannou A., Kennedy C.C., Ioannidis G. et al. The osteoporosis care gap in men with fragility fractures: the Canadian Multicentre Osteoporosis Study. Osteoporos Int. 2008; 19: 581-587. https://doi.org/10.1007/s00198-007-0483-0</mixed-citation><mixed-citation xml:lang="en">Papaioannou A., Kennedy C.C., Ioannidis G. et al. The osteoporosis care gap in men with fragility fractures: the Canadian Multicentre Osteoporosis Study. Osteoporos Int. 2008; 19: 581-587. https://doi.org/10.1007/s00198-007-0483-0</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lesnyak O., Ershova O., Belova K., et al. Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Arch Osteoporos. 2012; 7 (1-2): 67-73. https://doi.org/10.1007/s11657-012-0082-3</mixed-citation><mixed-citation xml:lang="en">Lesnyak O., Ershova O., Belova K., et al. Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Arch Osteoporos. 2012; 7 (1-2): 67-73. https://doi.org/10.1007/s11657-012-0082-3</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis J.A., Johnell O., De Laet C., et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004; 35 (2): 375382. https://doi.org/10.1016/j.bone.2004.03.024</mixed-citation><mixed-citation xml:lang="en">Kanis J.A., Johnell O., De Laet C., et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004; 35 (2): 375382. https://doi.org/10.1016/j.bone.2004.03.024</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Klotzbuecher C.M., Ross P.D., Landsman P.B., Abbott 3rd T.A., Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res. 2000; 15 (4): 721-739. https://doi.org/10.1359/jbmr.2000.15.4.721</mixed-citation><mixed-citation xml:lang="en">Klotzbuecher C.M., Ross P.D., Landsman P.B., Abbott 3rd T.A., Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res. 2000; 15 (4): 721-739. https://doi.org/10.1359/jbmr.2000.15.4.721</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Port L., Center J., Briffa N.K. et al. Osteoporotic fracture: missed opportunity for intervention. Osteoporos Int. 2003; 14 (9): 780-784. https://doi.org/10.1007/s00198-003-1452-x</mixed-citation><mixed-citation xml:lang="en">Port L., Center J., Briffa N.K. et al. Osteoporotic fracture: missed opportunity for intervention. Osteoporos Int. 2003; 14 (9): 780-784. https://doi.org/10.1007/s00198-003-1452-x</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">McLellan A., Reid D., Forbes K. et al. Effectiveness of Strategies for the Secondary Prevention of Osteoporotic Fractures in Scotland (CEPS 99/03). NHS Quality Improvement Scotland. 2004.</mixed-citation><mixed-citation xml:lang="en">McLellan A., Reid D., Forbes K. et al. Effectiveness of Strategies for the Secondary Prevention of Osteoporotic Fractures in Scotland (CEPS 99/03). NHS Quality Improvement Scotland. 2004.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards B.J., Bunta A.D., Simonelli C., Bolander M., Fitzpatrick L.A. Prior fractures are common in patients with subsequent hip fractures. Clin Orthop Relat Res. 2007; 461: 226-230. https://doi.org/10.1097/blo.0b013e3180534269</mixed-citation><mixed-citation xml:lang="en">Edwards B.J., Bunta A.D., Simonelli C., Bolander M., Fitzpatrick L.A. Prior fractures are common in patients with subsequent hip fractures. Clin Orthop Relat Res. 2007; 461: 226-230. https://doi.org/10.1097/blo.0b013e3180534269</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wells G.A., Cranney A., Peterson J., et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev 2008; (1): CD001155. https://doi.org/10.1002/14651858.cd001155.pub2</mixed-citation><mixed-citation xml:lang="en">Wells G.A., Cranney A., Peterson J., et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev 2008; (1): CD001155. https://doi.org/10.1002/14651858.cd001155.pub2</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Palacios S., Kalouche-Khalil L., Rizzoli R., et al. Treatment with denosumab reduces secondary fracture risk in women with postmenopausal osteoporosis. Climacteric. 2015; 18(6): 805-12. https://doi.org/10.3109/13697137.2015.1045484</mixed-citation><mixed-citation xml:lang="en">Palacios S., Kalouche-Khalil L., Rizzoli R., et al. Treatment with denosumab reduces secondary fracture risk in women with postmenopausal osteoporosis. Climacteric. 2015; 18(6): 805-12. https://doi.org/10.3109/13697137.2015.1045484</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Neer R.M., Arnaud C.D., Zanchetta J.R., et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001; 344(19): 1434-41. https://doi.org/10.3171/foc.2001.11.2.8</mixed-citation><mixed-citation xml:lang="en">Neer R.M., Arnaud C.D., Zanchetta J.R., et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001; 344(19): 1434-41. https://doi.org/10.3171/foc.2001.11.2.8</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lyles K.W., Colon-Emeric C.S., Magaziner J.S., et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007; 357(18): 1799-809. https://doi.org/10.1056/nejmoa074941</mixed-citation><mixed-citation xml:lang="en">Lyles K.W., Colon-Emeric C.S., Magaziner J.S., et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007; 357(18): 1799-809. https://doi.org/10.1056/nejmoa074941</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Akesson K., Marsh D., Mitchell P.J. et al.: IOF Fracture Working Group. Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle. Osteoporos Int. 2013; 24 (8): 2135-2152. https://doi.org/10.1007/s00198-013-2348-z</mixed-citation><mixed-citation xml:lang="en">Akesson K., Marsh D., Mitchell P.J. et al.: IOF Fracture Working Group. Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle. Osteoporos Int. 2013; 24 (8): 2135-2152. https://doi.org/10.1007/s00198-013-2348-z</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hagino H., Sawaguchi T., Endo N., et al. The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int. 2012; 90: 14-21. https://doi.org/10.1007/s00223-011-9545-6</mixed-citation><mixed-citation xml:lang="en">Hagino H., Sawaguchi T., Endo N., et al. The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int. 2012; 90: 14-21. https://doi.org/10.1007/s00223-011-9545-6</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ganda K., Mitchell P.J., Seibel M.J. Chapter 3 — Models of Secondary Fracture Prevention: Systematic Review and Meta-analysis of Outcomes. Secondary Fracture Prevention. An International Perspective. 2019. P. 33-62. https://doi.org/10.1016/b978-0-12-813136-7.00003-x</mixed-citation><mixed-citation xml:lang="en">Ganda K., Mitchell P.J., Seibel M.J. Chapter 3 — Models of Secondary Fracture Prevention: Systematic Review and Meta-analysis of Outcomes. Secondary Fracture Prevention. An International Perspective. 2019. P. 33-62. https://doi.org/10.1016/b978-0-12-813136-7.00003-x</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Marsh D., Akesson K., Beaton D.E. et al. Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int. 2011; 22: 2051-2065. https://doi.org/10.1007/s00198-011-1642-x</mixed-citation><mixed-citation xml:lang="en">Marsh D., Akesson K., Beaton D.E. et al. Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int. 2011; 22: 2051-2065. https://doi.org/10.1007/s00198-011-1642-x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Eisman J.A., Bogoch E.R., Dell R., et al.. Making the first fracture the last fracture: ASBMR Task Force on Secondary Fracture Prevention. J Bone Miner Res. 2012 Oct; 27(10): 2039-46. https://doi.org/10.1002/jbmr.1698</mixed-citation><mixed-citation xml:lang="en">Eisman J.A., Bogoch E.R., Dell R., et al.. Making the first fracture the last fracture: ASBMR Task Force on Secondary Fracture Prevention. J Bone Miner Res. 2012 Oct; 27(10): 2039-46. https://doi.org/10.1002/jbmr.1698</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">International Osteoporosis Foundation. Capture the Fracture: a global campaign to break the fragility fracture cycle — 2012 // International Osteoporosis Foundation: сайт. — Режим доступа: https://www.iofbonehealth.org/capture-fracture-report-2012. — Загл. с экрана.</mixed-citation><mixed-citation xml:lang="en">International Osteoporosis Foundation. Capture the Fracture: a global campaign to break the fragility fracture cycle — 2012 // International Osteoporosis Foundation: сайт. — Режим доступа: https://www.iofbonehealth.org/capture-fracture-report-2012. — Загл. с экрана.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">International Osteoporosis Foundation. Capture the Fracture: break the worldwide fragility fracture cycle — 2012 // International Osteoporosis Foundation: сайт. — Режим доступа: https://www.iofbonehealth.org/capture-fracture. — Загл. с экрана</mixed-citation><mixed-citation xml:lang="en">International Osteoporosis Foundation. Capture the Fracture: break the worldwide fragility fracture cycle — 2012 // International Osteoporosis Foundation: сайт. — Режим доступа: https://www.iofbonehealth.org/capture-fracture. — Загл. с экрана</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sale J.E., Beaton D., Posen J., et al. Systematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patients. Osteoporos Int. 2011; 22: 2067-2082. https://doi.org/10.1007/s00198-011-1544-y</mixed-citation><mixed-citation xml:lang="en">Sale J.E., Beaton D., Posen J., et al. Systematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patients. Osteoporos Int. 2011; 22: 2067-2082. https://doi.org/10.1007/s00198-011-1544-y</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Dell R. Fracture prevention in Kaiser Permanente Southern California. Osteoporos Int. 2011; 22 Suppl 3: 457-60. https://doi.org/10.1007/s00198-011-1712-0</mixed-citation><mixed-citation xml:lang="en">Dell R. Fracture prevention in Kaiser Permanente Southern California. Osteoporos Int. 2011; 22 Suppl 3: 457-60. https://doi.org/10.1007/s00198-011-1712-0</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lih A., Nandapalan H., Kim M., et al. Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study. Osteoporos Int. 2011; 22(3): 849-58. https://doi.org/10.1007/s00198-010-1477-x</mixed-citation><mixed-citation xml:lang="en">Lih A., Nandapalan H., Kim M., et al. Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study. Osteoporos Int. 2011; 22(3): 849-58. https://doi.org/10.1007/s00198-010-1477-x</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Huntjens K.M., van Geel T.A., van den Bergh J.P., et al. Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality. J Bone Joint Surg Am. 2014; 96(4): e29. https://doi.org/10.2106/jbjs.l.00223</mixed-citation><mixed-citation xml:lang="en">Huntjens K.M., van Geel T.A., van den Bergh J.P., et al. Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality. J Bone Joint Surg Am. 2014; 96(4): e29. https://doi.org/10.2106/jbjs.l.00223</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Kallen J., Giles M., Cooper K., et al. A fracture prevention service reduces further fractures two years after incident minimal trauma fracture. Int J Rheum Dis. 2014; 17(2): 195-203 https://doi.org/10.1111/1756-185x.12101</mixed-citation><mixed-citation xml:lang="en">Van der Kallen J., Giles M., Cooper K., et al. A fracture prevention service reduces further fractures two years after incident minimal trauma fracture. Int J Rheum Dis. 2014; 17(2): 195-203 https://doi.org/10.1111/1756-185x.12101</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Olenginski T.P., Maloney-Saxon G., Matzko C.K., et al. High-risk osteoporosis clinic (HiROC): improving osteoporosis and postfracture care with an organized, programmatic approach. Osteoporos Int. 2015; 26(2): 801-10 https://doi.org/10.1007/s00198-014-2967-z</mixed-citation><mixed-citation xml:lang="en">Olenginski T.P., Maloney-Saxon G., Matzko C.K., et al. High-risk osteoporosis clinic (HiROC): improving osteoporosis and postfracture care with an organized, programmatic approach. Osteoporos Int. 2015; 26(2): 801-10 https://doi.org/10.1007/s00198-014-2967-z</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ganda K., Schaffer A., Pearson S., Seibel M.J. Compliance and persistence to oral bisphosphonate therapy following initiation within a secondary fracture prevention program: a randomised controlled trial of specialist vs. non-specialist management. Osteoporos Int. 2014; 25 (4): 1345-1355. https://doi.org/10.1007/s00198-013-2610-4</mixed-citation><mixed-citation xml:lang="en">Ganda K., Schaffer A., Pearson S., Seibel M.J. Compliance and persistence to oral bisphosphonate therapy following initiation within a secondary fracture prevention program: a randomised controlled trial of specialist vs. non-specialist management. Osteoporos Int. 2014; 25 (4): 1345-1355. https://doi.org/10.1007/s00198-013-2610-4</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Little E.A., Eccles M.P. A systematic review of the effectiveness of interventions to improve post-fracture investigation and management of patients at risk of osteoporosis. Implement. Sci. 2010; 5: 80. https://doi.org/10.1186/1748-5908-5-80</mixed-citation><mixed-citation xml:lang="en">Little E.A., Eccles M.P. A systematic review of the effectiveness of interventions to improve post-fracture investigation and management of patients at risk of osteoporosis. Implement. Sci. 2010; 5: 80. https://doi.org/10.1186/1748-5908-5-80</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Javaid M.K., Sami A., Lems W. et al. A patient-level key performance indicator set to measure the effectiveness of fracture liaison services and guide quality improvement: a position paper of the IOF Capture the Fracture Working Group, National Osteoporosis Foundation and Fragility Fracture Network. Osteoporosis International. 2020; 31: 1193-1204. https://doi.org/10.1007/s00198-020-05377-1</mixed-citation><mixed-citation xml:lang="en">Javaid M.K., Sami A., Lems W. et al. A patient-level key performance indicator set to measure the effectiveness of fracture liaison services and guide quality improvement: a position paper of the IOF Capture the Fracture Working Group, National Osteoporosis Foundation and Fragility Fracture Network. Osteoporosis International. 2020; 31: 1193-1204. https://doi.org/10.1007/s00198-020-05377-1</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Gittoes N., McLellan A.R., Cooper A. et al. Effective Secondary Prevention of Fragility Fractures: Clinical Standards for Fracture Liaison Services. Camerton: National Osteoporosis Society. 2015.</mixed-citation><mixed-citation xml:lang="en">Gittoes N., McLellan A.R., Cooper A. et al. Effective Secondary Prevention of Fragility Fractures: Clinical Standards for Fracture Liaison Services. Camerton: National Osteoporosis Society. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Shipman K.E., Stammers J., Doyle A., Gittoes N. Delivering a quality-assured fracture liaison service in a UK teaching hospital-is it achievable? Osteoporos Int. 2016. https://doi.org/10.1007/s00198-016-3639-y</mixed-citation><mixed-citation xml:lang="en">Shipman K.E., Stammers J., Doyle A., Gittoes N. Delivering a quality-assured fracture liaison service in a UK teaching hospital-is it achievable? Osteoporos Int. 2016. https://doi.org/10.1007/s00198-016-3639-y</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Royal College of Physicians Falls and Fragility Fracture Audit Programme. Fracture Liaison Service Database (FLS-DB) facilities audit. FLS breakpoint: opportunities for improving patient care following a fragility fracture. London: 2016.</mixed-citation><mixed-citation xml:lang="en">Royal College of Physicians Falls and Fragility Fracture Audit Programme. Fracture Liaison Service Database (FLS-DB) facilities audit. FLS breakpoint: opportunities for improving patient care following a fragility fracture. London: 2016.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gallacher S., Alexander S., Beswetherick Will Carr N. et al. Effective Secondary Prevention of Fragility Fractures: Clinical Standards for Fracture Liaison Services. Royal Osteoporosis Society. 2019.</mixed-citation><mixed-citation xml:lang="en">Gallacher S., Alexander S., Beswetherick Will Carr N. et al. Effective Secondary Prevention of Fragility Fractures: Clinical Standards for Fracture Liaison Services. Royal Osteoporosis Society. 2019.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute for Health and Clinical Excellence. Alendronate, etidronate, risedronate, raloxifene, strontium ranelate and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal women: NICE Technology Appraisal Guidance 161. 2010.</mixed-citation><mixed-citation xml:lang="en">National Institute for Health and Clinical Excellence. Alendronate, etidronate, risedronate, raloxifene, strontium ranelate and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal women: NICE Technology Appraisal Guidance 161. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Мельниченко Г.А., Белая Ж.Е., Рожинская Л.Я. с соавт. Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза. Проблемы Эндокринологии. 2017; 63 (6): 392-426 https://doi.org/10.14341/probl2017636392-426</mixed-citation><mixed-citation xml:lang="en">Mel'nichenko GA, Belaya ZhE, Rozhinskaya LYа s soavt. Federal'nye klinicheskie rekomendacii po diagnostike, lecheniyu i profilaktike osteoporoza. Problemy Endokrinologii, 2017; 63 (6): 392-426 https://doi.org/10.14341/probl2017636392-426</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
