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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">geriatr</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал гериатрической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Geriatric Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8636</issn><issn pub-type="epub">2686-8709</issn><publisher><publisher-name>Сайт издателя</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37586/2686-8636-1-2021-82-87</article-id><article-id custom-type="elpub" pub-id-type="custom">geriatr-121</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Планирование терапии боли в суставах при остеоартрите у пациентов с хронической болезнью почек</article-title><trans-title-group xml:lang="en"><trans-title>Joint pain treatment planning in osteoarthritis patients with chronic kidney disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6253-621X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наумов Антон Вячеславович, доктор медицинских наук, профессор кафедры болезней старения ФДПО ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, зав. лабораторией заболеваний костно-мышечной системы ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский ГНКЦ.</p><p>Москва</p></bio><bio xml:lang="en"><p>Naumov Anton V., MD, PhD, Head of bone and muscular dis-eases laboratory.</p><p>Moscow</p></bio><email xlink:type="simple">naumov_av@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1628-5093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котовская Юлия Викторовна, доктор медицинских наук, профессор, заместитель директора по научной работе.</p><p>Москва, телефон: +7(499)187-78-09</p></bio><bio xml:lang="en"><p>Kotovskaya Yulia V., MD, PhD, professor, Deputy Director.</p><p>Moscov</p></bio><email xlink:type="simple">kotovskaya_yv@rgnkc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6040-1090</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мороз</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Moroz</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мороз Виктория Ивановна, ассистент кафедры болезней старения.</p><p>Москва, телефон: +7(985)516-09-51</p></bio><bio xml:lang="en"><p>Moroz Victoria I., Agerelated diseases Department, Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow</p></bio><email xlink:type="simple">vikulya-moroz@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3066-4866</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ховасова</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Khovasova</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ховасова Наталья Олеговна, кандидат медицинских наук, доцент кафедры болезней старения ФДПО ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, старший научный сотрудник лаборатории заболеваний костно-мышечной системы ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский ГНКЦ.</p><p>Москва, телефон: +7(915)004-43-00</p></bio><bio xml:lang="en"><p>Khovasova Natalia O., MD, PhD, associate professor, Agerelated diseases Department, Pirogov National Research Medical University, senior research fellow, Laboratory of musculoskeletal diseases, Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow</p></bio><email xlink:type="simple">natashahov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5187-0108</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мешков</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshkov</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мешков Алексей Дмитриевич, кандидат медицинских наук, врач-ревматолог, старший научный сотрудник лаборатории заболеваний костно-мышечной системы Российского геронтологического научно-клинического центра, ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России.</p><p>Москва</p></bio><bio xml:lang="en"><p>Meshkov Alexey D., MD, PhD, rheumatologist, senior researcher of the laboratory of diseases of the musculoskeletal system, Pirogov National Research Medical University, Russian Gerontology Research and Clinical Centre.</p><p>Moscow</p></bio><email xlink:type="simple">alexeymeshkov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2196-1068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маневич</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manevich</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маневич Татьяна Михайловна, кандидат медицинских наук, заведующая отделением гериатрической неврологии.</p><p>Москва, телефон: +7(903)675-88-02</p></bio><bio xml:lang="en"><p>Manevich Tatiana M., MD, PhD, Head of Neurology department.</p><p>Moscow</p></bio><email xlink:type="simple">Nadezda5775@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9837-4224</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деменок</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demenok</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Деменок Дмитрий Викторович, врач-рентгенолог отделения лучевой диагностики.</p><p>Москва, Телефон: +7(915)213-18-52</p></bio><bio xml:lang="en"><p>Demenok Dmitry V., radiologist of the radiology department.</p><p>Moscow</p></bio><email xlink:type="simple">dr.demenok@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центр<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University, Russian Gerontology Research and Clinical Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>04</month><year>2021</year></pub-date><volume>0</volume><issue>1</issue><fpage>82</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Наумов А.В., Котовская Ю.В., Мороз В.И., Ховасова Н.О., Мешков А.Д., Маневич Т.М., Деменок Д.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Наумов А.В., Котовская Ю.В., Мороз В.И., Ховасова Н.О., Мешков А.Д., Маневич Т.М., Деменок Д.В.</copyright-holder><copyright-holder xml:lang="en">Naumov A.V., Kotovskaya Y.V., Moroz V.I., Khovasova N.O., Meshkov A.D., Manevich T.M., Demenok D.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.geriatr-news.com/jour/article/view/121">https://www.geriatr-news.com/jour/article/view/121</self-uri><abstract><p>Лечение остеоартрита, как самой частой патологии костно-мышечной системы, представляет определенные клинические трудности у коморбидных больных. Частое сочетание остеоартрита (ОА) с сердечно-сосудистыми заболеваниями (ССЗ), сахарным диабетом 2 типа и другими кардиометаболическими патологиями ставит вопросы о безопасности обезболивающих средств при наличии хронической болезни почек (ХБП). </p><p>Безопасное лечение хронического болевого синдрома подразумевает взвешенное решение о риске/пользе от использования любых анальгетических интервенций. Особое внимание стоит уделять решению о назначении нестероидных противовоспалительных препаратов (НПВП). Альтернативной стратегией терапии боли в суставах у пациентов с ХБП может служить использование рецептурной формы хондроитина сульфата.</p><p>Особое внимание следует уделить возможности использования парентеральной формы препарата, имеющей надежные доказательные данные, более быстрые сроки наступления клинического эффекта анальгезии, с потенциальным протекторным эффектом в отношении структуры тканей суставов.</p></abstract><trans-abstract xml:lang="en"><p>Treatment of osteoarthritis, as the most common pathology of the musculoskeletal system, presents certain clinical difﬁculties in comorbid patients. The frequent combination of osteoarthritis (OA) and cardiovascular diseases (CVD), diabetes mellitus type 2 and other cardiometabolic pathologies raises questions about the safety of pain relievers in the presence of chronic kidney disease (CKD). Safe treatment for chronic pain syndrome implies an informed decision about the risks / beneﬁts of using any analgesic intervention. Particular attention should be paid to the decision on the appointment of non-steroidal anti-inﬂammatory drugs (NSAIDs). An alternative strategy for the treatment of joint pain in patients with CKD may be the use of chondroitin sulfate prescription form. Particular attention should be paid to the possibility of using the parenteral form of the drug, which has reliable evidence, faster onset of the clinical effect of analgesia, with a potential protective effect on the structure of joint tissues.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>остеоартроз</kwd><kwd>хроническая болезнь почек</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>сахар-ный диабет</kwd><kwd>НПВП</kwd><kwd>хондроитина сульфат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>osteoarthrosis</kwd><kwd>chronic kidney disease</kwd><kwd>cardiovascular diseases</kwd><kwd>diabetes</kwd><kwd>NSAIDs</kwd><kwd>chondroitin sulfate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Calders P., Van Ginckel A. 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